Virus-Induced Pathogenic Antibodies: Lessons from Long COVID and Dengue Hemorrhage Fever

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1898 - 1898

Published: Feb. 22, 2025

Virus-induced antibodies represent a dual-edged sword in the immune response to viral infections. While are critical for neutralizing pathogens, some can paradoxically exacerbate disease severity through mechanisms such as antibody-dependent enhancement (ADE), autoantibody, and prolonged inflammation. Long coronavirus (COVID) dengue hemorrhagic fever (DHF) exemplify conditions where pathogenic play pivotal role progression. COVID is associated with persistent dysregulation autoantibody production, leading chronic symptoms tissue damage. In DHF, pre-existing against virus contribute ADE, amplifying replication, activation, vascular permeability. This review explores underlying these antibody responses, highlighting shared pathways of comparing distinct features both conditions. By examining studies, we identify key lessons therapeutic strategies, vaccine design, future research aimed at mitigating severe outcomes

Language: Английский

---

Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

SARS-CoV-2 infection activates macrophages and induces the release of neutrophil extracellular traps (NETs). Excess NETs is linked to inflammatory thrombotic complications observed in COVID-19. To explore impact macrophage activation on SARS-CoV-2-infected patients who developed complications. We included 30 from first (March 2020) second wave (July 2021), collecting two plasma samples at diagnosis seven days later. Data demographics, comorbidities, basic analytical data were compiled. markers (myeloperoxidase (MPO), elastase (NE), p-selectin (P-SEL) S100A8/S100A9 heterodimer (MRP)) (Chitotriosidase activity (ChT), CCL18/PARC YKL-40) measured. The had higher incidences post-COVID syndrome, ICU admissions, mortality. Patients each showed elevated blood cells, liver enzymes, coagulation time diagnosis, with fibrinogen D-Dimer differing between waves. NET markers, NE, MPO, MRP, DNAse, ChT, CCL18 elevated, while P-SEL, cfDNA, YKL-40 decreased if compared controls. A decrease NE DNAse a link lower levels these versus without This study emonstrates alterations COVID-19 patients, indicating an imbalance response regulation.

Language: Английский

---

Nasal cytological evidence of chronic inflammation in the olfactory cleft in post-viral olfactory dysfunction

European Archives of Oto-Rhino-Laryngology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Language: Английский

---

Establishing a prediction model for lower extremity deep venous thrombosis in emergency inpatients in the post epidemic era

Frontiers in Surgery, Journal Year: 2025, Volume and Issue: 12

Published: April 7, 2025

This study aimed to analyze the risk factors of lower extremity deep vein thrombosis (LEDVT) in emergency inpatients post-epidemic era, and establish a prediction model for identifying high-risk patients LEDVT. Emergency admitted our hospital from June 2022 2023 were divided into two groups: epidemic group group. The baseline characteristics, blood routine, liver kidney function, coagulation LE ultrasonography compared between groups. Multivariate logistic analysis receiver operating character (ROC) curve used evaluate effectiveness LEDVT era. A total 967 analyzed, including 388 cases 579 portion (33.2%) was significantly higher than that (26.8%, P = 0.036). Binary Logistic regression showed age, smoking history, drinking history glycosylated hemoglobin (HBA1c) independent thrombosis. established as 0.863 × age + 0.978 0.702 0.104 HBA1c - 2.439. area under ROC 0.718. incidence era period. Age, are at high

Language: Английский

---

The Significance of Endothelial Dysfunction in Long COVID-19 for the Possible Future Pandemic of Chronic Kidney Disease and Cardiovascular Disease

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 965 - 965

Published: Aug. 8, 2024

Various symptoms have been reported to persist beyond the acute phase of severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which is referred as long disease 19 (long COVID-19). Over 65 million individuals suffer from COVID-19. However, causes COVID-19 are largely unknown. Since observed throughout body, vascular endothelial dysfunction a strong candidate explaining induction The angiotensin-converting enzyme (ACE2), entry receptor for SARS-CoV-2, ubiquitously expressed in cells. We previously found that risk factors atherosclerotic cardiovascular (ASCVD) and history ASCVD raise COVID-19, suggesting contribution pre-existing Here, we show significant association with development biomarkers patients also crucial players ASCVD. consider influence on chronic kidney (CKD) Future assessments outcomes resulting therapeutic interventions improve function may imply significance

Language: Английский

---

Insights into Long COVID: Unraveling Risk Factors, Clinical Features, Radiological Findings, Functional Sequelae and Correlations: A Retrospective Cohort Study

The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

---

Organ-Dysfunction Markers in Mild-to-Moderate COVID-19 Convalescents

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(8), P. 2241 - 2241

Published: April 12, 2024

Background: A coronavirus disease 2019 (COVID-19) outbreak led to a worldwide pandemic. COVID-19 not only caused acute symptoms during the severe phase of disease, but also induced long-term side effects on functioning many organs and systems. Symptoms that were associated with present at least 3 months after recovery named long COVID. The aim this study was assess if mild-to-moderate may lead dysfunction respiratory, cardiovascular, neural, renal systems in healthy blood donors who recovered from 6 earlier. Methods: Here, we examined 294 adults among volunteer divided into convalescents (n = 215) controls 79). Concentrations soluble CD163, TGF beta, Lp-PLA2, NCAM-1, S100, NGAL, creatinine measured either by ELISA or automated methods. probability value p < 0.05 considered as statistically significant. Results: We found significant differences NCAM-1 between never-infected subjects. Lp-PLA2 lower, S100 higher, than control group. Conclusion: Mild-to-moderate are low risk developing lung fibrosis chronic kidney disease. However, they should regularly carry out their prophylaxis examinations for early detection possible negative outcomes COVID-19.

Language: Английский

---

An intelligent garment for long COVID-19 real-time monitoring

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 181, P. 109067 - 109067

Published: Aug. 25, 2024

As monitoring and diagnostic tools for long COVID-19 cases, wearable systems supervised learning-based medical image analysis have proven to be useful. Current research on these two technical roadmaps has various drawbacks, despite their respective benefits. Wearable allow only the real-time of physiological parameters (heart rate, temperature, blood oxygen saturation, or SpO

Language: Английский

---

Circulating miRNAs in the Plasma of Post-COVID-19 Patients with Typical Recovery and Those with Long-COVID Symptoms: Regulation of Immune Response-Associated Pathways

Non-Coding RNA, Journal Year: 2024, Volume and Issue: 10(5), P. 48 - 48

Published: Sept. 2, 2024

Following the acute phase of SARS-CoV-2 infection, certain individuals experience persistent symptoms referred to as long COVID. This study analyzed patients categorized into three distinct groups: (1) presenting rheumatological associated with COVID, (2) who have successfully recovered from COVID-19, and (3) donors never contracted COVID-19. A notable decline in expression miR-200c-3p, miR-766-3p, miR-142-3p was identified among exhibiting The highest concentration found healthy donors. One potential way reduce miRNA concentrations is through antibody-mediated hydrolysis. Not only can antibodies possessing RNA-hydrolyzing activity recognize substrate specifically, but they also catalyze its analysis catalytic plasma revealed that COVID demonstrated lower hydrolysis against five fluorescently labeled oligonucleotide sequences corresponding Flu-miR-146b-5p, Flu-miR-766-3p, Flu-miR-4742-3p, Flu-miR-142-3p miRNAs increased Flu-miR-378a-3p compared other patient groups. changes are assumed a complex regulatory mechanism linked gene pathways immune system. We demonstrate all six under large number signaling response-associated pathways.

Language: Английский

---

The evaluation of SARS-CoV-2 mutations at the early stage of the pandemic in Istanbul population

Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 10, 2024

Determination of SARS-CoV-2 variant is significant to prevent the spreads COVID-19 disease.

Language: Английский

---