Seminars in Fetal and Neonatal Medicine, Journal Year: 2023, Volume and Issue: 28(1), P. 101428 - 101428
Published: Feb. 1, 2023
Language: Английский
BMJ Global Health, Journal Year: 2022, Volume and Issue: 7(2), P. e007730 - e007730
Published: Feb. 1, 2022
Gaps in information about the safety and efficacy of COVID-19 vaccines pregnancy have led to substantial global variation public health guidance regarding use over course pandemic.
Language: Английский
Citations
37
Ultrasound in Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 59(6), P. 813 - 822
Published: March 30, 2022
To describe the placental pathology, fetal autopsy findings and clinical characteristics of pregnancies that resulted in stillbirth owing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) placentitis, identify potential risk factors.This was a prospective multicenter study non-vaccinated pregnant women affected by disease 2019 (COVID-19) Greece from April 2020 August 2021. A total 165 placentas were examined histologically six cases associated with SARS-CoV-2 placentitis retrieved. Complete performed three these cases. Gross, histopathological, immunohistochemical, molecular electron microscopy examinations carried out organs. The histological compared those 159 maternal COVID-19 which live birth. Regression analysis used predisposing factors for placentitis.The all stillborn showed extensive changes typical characterized combination marked intervillositis mixed inflammatory infiltrate massive perivillous fibrinoid deposition trophoblast damage, intensely positive immunostaining spike protein, presence virions on reverse-transcription polymerase chain reaction test tissues. lesions obliterated over 75% intervillous space, accounting intrauterine death. Similar affecting less than 25% placenta observed seven liveborn neonates, while remaining 152 COVID-19-affected birth did not show findings. evidence an asphyctic mode death without viral transmission fetus. mothers had mild symptoms or asymptomatic, interval between diagnosis ranged 3 15 days. Statistically significant included thrombophilia prenatally diagnosed growth restriction (FGR). Multiple sclerosis seen one case.SARS-CoV-2 occurred uncommonly and, when extensive, caused demise, no transplacental infection. Thrombophilia detected FGR emerged as independent potentially lethal placentitis. © 2022 International Society Ultrasound Obstetrics Gynecology.
Language: Английский
Citations
31
Clinical Reviews in Allergy & Immunology, Journal Year: 2022, Volume and Issue: 64(2), P. 145 - 160
Published: Jan. 15, 2022
Language: Английский
Citations
30
Nature Cell Biology, Journal Year: 2023, Volume and Issue: 25(8), P. 1223 - 1234
Published: July 13, 2023
Abstract SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19 during pregnancy to negative birth outcomes and placentitis. However, the pathophysiological mechanisms underpinning placentation early are not clear. Here, shed light on this, we used induced trophoblast stem cells generate an in vitro placenta model. We identified that syncytiotrophoblasts could be infected through angiotensin-converting enzyme 2 (ACE2). Using a co-culture model of vertical transmission, confirmed ability virus infect previous endometrial cell infection. further demonstrated transcriptional changes led impairment cellular processes, reduced secretion HCG hormone morphological vital for syncytiotrophoblast function. Furthermore, different antibody strategies antiviral drugs restore these impairments. In summary, established scalable tractable platform study placental types highlighted its use studying protect placenta.
Language: Английский
Citations
21
Seminars in Fetal and Neonatal Medicine, Journal Year: 2023, Volume and Issue: 28(1), P. 101428 - 101428
Published: Feb. 1, 2023
Language: Английский
Citations
19