International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2741 - 2741
Published: Feb. 27, 2024
Pre-eclampsia
is
a
serious
complication
of
pregnancy
characterized
by
state
multiorgan
hypertensive
disorders,
with
or
without
proteinuria
and
possible
dysfunction.
Chronic
kidney
disease
an
established
risk
factor
for
the
development
pre-eclampsia,
as
angiogenic
homeostasis
altered
maternal
circulation
already
hypertensive.
Facing
pre-eclampsia
in
context
chronic
challenging
emergency
both
mother
fetus.
The
clinical
features
management
this
multi-organ
disorder
are
clearly
defined
modern
literature
but
underlying
pathophysiologic
mechanisms
remain
not
fully
elucidated.
Understanding
pathophysiology
that
mediates
onset
itself
synergy
fundamental
developing
prompt
prevention
strategies,
treatment
planning,
patient
counseling.
This
review
aims
to
summarize
main
molecular
involved
process
particular
focus
on
role
kidneys
hormonal
pathways
related
renal
function
normal
pre-eclamptic
syndromes.
Communications Biology,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Jan. 5, 2024
Abstract
Preeclampsia
is
a
multifactorial
and
heterogeneous
complication
of
pregnancy.
Here,
we
utilize
single-cell
RNA
sequencing
to
dissect
the
involvement
circulating
immune
cells
in
preeclampsia.
Our
findings
reveal
downregulation
response
lymphocyte
subsets
preeclampsia,
such
as
reduction
natural
killer
cytotoxic
genes
expression,
expansion
regulatory
T
cells.
But
activation
naïve
cell
monocyte
subsets,
well
increased
MHC-II-mediated
pathway
antigen-presenting
were
still
observed
Notably,
identified
key
with
significantly
expression
angiogenesis
pathways
pro-inflammatory
S100
family
VCAN
+
monocytes
IFN
non-classical
monocytes.
Furthermore,
four
cell-type-specific
machine-learning
models
have
been
developed
identify
potential
diagnostic
indicators
Collectively,
our
study
demonstrates
transcriptomic
alternations
identifies
components
that
could
be
involved
pathophysiology
Cell Proliferation,
Journal Year:
2024,
Volume and Issue:
57(8)
Published: March 19, 2024
Abstract
Cardiovascular
disease
(CVD)
is
a
group
of
diseases
that
primarily
affect
the
heart
or
blood
vessels,
with
high
disability
and
mortality
rates,
posing
serious
threat
to
human
health.
The
causative
factors,
pathogenesis,
characteristics
common
CVD
differ,
but
they
all
involve
pathological
processes
such
as
inflammation,
oxidative
stress,
fibrosis.
S100A9
belongs
S100
family
calcium‐binding
proteins,
which
are
mainly
secreted
by
myeloid
cells
bind
Toll‐like
receptor
4
for
advanced
glycation
end
products
involved
in
regulating
inflammatory
response,
fibrosis,
vascular
calcification,
endothelial
barrier
function
CVD.
latest
research
has
found
key
biomarker
diagnosing
predicting
various
Therefore,
this
article
reviews
progress
on
diagnostic
predictive,
therapeutic
value
inflammatory‐related
atherosclerosis,
myocardial
infarction,
arterial
aneurysm
summarizes
its
molecular
mechanisms
progression
CVD,
aiming
explore
new
predictive
methods
identify
potential
intervention
targets
clinical
practice.
