An update review of the application of single-cell RNA sequencing in pregnancy-related diseases DOI Creative Commons
Zimo Zhou, Xiuhua Yang

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Reproductive success hinges on the presence of a robust and functional placenta. Examining placenta provides insight about progression pregnancy valuable information normal developmental trajectory fetus. The current limitations using bulk RNA-sequencing (RNA-seq) analysis stem from diverse composition placenta, hindering comprehensive description how distinct trophoblast cell expression patterns contribute to establishment sustenance successful pregnancy. At present, transcriptional landscape intricate tissues increasingly relies single-cell RNA sequencing (scRNA-seq). A few investigations have utilized scRNA-seq technology examine codes governing transcriptome regulation in cells at maternal-fetal interface. In this review, we explore fundamental principles technology, offering latest overview human placental studies utilizing method across various gestational weeks both pregnancies pregnancy-related diseases, including recurrent loss (RPL), preeclampsia (PE), preterm birth, diabetes mellitus (GDM). Furthermore, discuss future perspectives within realm reproduction. It seems that stands out as one crucial tools for studying etiology complications. direction applications may involve devolving into biology, with primary focus understanding variations activity among highly specific populations. Our goal is provide obstetricians an updated related complications, providing understandings aid diagnosis treatment these conditions, ultimately improving maternal fetal prognosis.

Language: Английский

Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae DOI Creative Commons
Michael D. Jochum,

Marcus Garcia,

Alexandra Hammerquist

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Recent analytical advancements have uncovered increasing micro- and nanoplastics (MNPs) in environmental, dietary, biological domains, raising concerns about their health impacts. Preterm birth (PTB), a leading cause of maternal neonatal morbidity mortality, may be influenced by MNP exposure, yet this relationship remains unexplored. This study quantified 12 polymers placentae from term (n=87) preterm (n=71) deliveries using pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). Cumulative concentrations were 28% higher PTB (mean ±SD: 224.7 ± 180.7 µg/g vs. 175.5 137.9 µg/g; p=0.038). Polyvinyl chloride (PVC), polyethylene terephthalate (PET), polyurethane (PU), polycarbonate (PC) significantly elevated PTB, PET, PU, PC inversely correlated with gestational age weight. Logistic regression identified PVC as independent predictors PTB. These findings suggest total specific MNPs are associated providing actionable insights emphasizing the importance minimizing exposure during pregnancy.

Language: Английский

Citations

0
Placental Weight as a Predictor of Future Health: Insights from a Large-scale Genome-wide Association Study DOI
Qinyi Zhang,

Tianhan Xu,

Sihui Yu

et al.

Placenta, Journal Year: 2025, Volume and Issue: 164, P. 10 - 20

Published: March 12, 2025

Language: Английский

Citations

0
Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes DOI

Dewei Kong,

Oliwia Kowalik,

Emma Garratt

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
An update review of the application of single-cell RNA sequencing in pregnancy-related diseases DOI Creative Commons
Zimo Zhou, Xiuhua Yang

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Reproductive success hinges on the presence of a robust and functional placenta. Examining placenta provides insight about progression pregnancy valuable information normal developmental trajectory fetus. The current limitations using bulk RNA-sequencing (RNA-seq) analysis stem from diverse composition placenta, hindering comprehensive description how distinct trophoblast cell expression patterns contribute to establishment sustenance successful pregnancy. At present, transcriptional landscape intricate tissues increasingly relies single-cell RNA sequencing (scRNA-seq). A few investigations have utilized scRNA-seq technology examine codes governing transcriptome regulation in cells at maternal-fetal interface. In this review, we explore fundamental principles technology, offering latest overview human placental studies utilizing method across various gestational weeks both pregnancies pregnancy-related diseases, including recurrent loss (RPL), preeclampsia (PE), preterm birth, diabetes mellitus (GDM). Furthermore, discuss future perspectives within realm reproduction. It seems that stands out as one crucial tools for studying etiology complications. direction applications may involve devolving into biology, with primary focus understanding variations activity among highly specific populations. Our goal is provide obstetricians an updated related complications, providing understandings aid diagnosis treatment these conditions, ultimately improving maternal fetal prognosis.

Language: Английский

Citations

0