The Importance of Gene Variants Related to Folate Uptake and Distribution in the Etiology of Recurrent Miscarriage and Intrauterine Fetal Demise DOI Creative Commons

Martyna Kozłowska-Wytyk,

Grażyna Kurzawińska, Marcin Ożarowski

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(24), P. 11847 - 11847

Published: Dec. 18, 2024

(1) Background: The study involves an assessment of the frequency selected gene variants related to folate uptake and distribution (FOLR1 rs2071010, rs630074, FOLH1 rs61886492, GGH rs11545078, rs3758149 SLC19A1 rs1051266) in a group women with fetal demise Polish population. (2) Methods: A total 310 subjects were enrolled study. There 110 females idiopathic recurrent miscarriages (RM), 80 stillbirth (IUFD) 120 healthy controls. Designated SNVs determined by using PCR-RFLP methods. difference prevalence was assessed chi-square test logistic regression analysis. (3) Results: rs630074 variant FOLR1 is associated statistically significant increase risk IUFD recessive model (OR = 2.03, 95%CI: 1.06–3.90, p 0.033). rs61886492variant f linked increased co-dominant (p 0.030), dominant 2.62, 1.07–6.38, 0.032) log-additive models 2.64, 1.15–6.06 0.030). In female carriers allele, 2.8 times higher compared control group. No relationship between mother’s genotype newborn’s birth weight or placental observed for studied SNVs. (4) Conclusions: Our finds that rs61886492 women. However, pregnancy failures have multifactorial pathology other genetic environmental factors may also contribute their complex etiology. Further research, preferably larger groups from different ethnic backgrounds, needed confirm results current

Language: Английский

Association between maternal rectovaginal group B streptococcus and the risk of stillbirth: a meta-analysis DOI Creative Commons
Yujue Wang, Jingjing Liu,

Jinlian Song

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e18834 - e18834

Published: Jan. 13, 2025

Group B streptococcus (GBS) colonization in pregnant women is associated with adverse perinatal outcomes, including stillbirth. This meta-analysis investigated the relationship between maternal rectovaginal GBS and risk of We conducted a comprehensive literature search across several databases, PubMed, Embase, Web Science, Wanfang, China National Knowledge Infrastructure, covering studies published from inception database until September 9, 2024. The focused on observational comparing stillbirth without colonization. Results were summarized using odds ratios (ORs) 95% confidence intervals (CIs), random-effects model was used to account for potential heterogeneity. A total ten comprising 121,195 included analysis. pooled results indicated no significant overall association (OR: 1.66, CI [0.95-2.91], p = 0.08; I2 84%). However, sensitivity analyses revealed that intrapartum antibiotic prophylaxis (IAP) 1.36, [1.02-1.80], 0.03). Subgroup demonstrated retrospective 2.62, 0.04) employing multivariate analysis 2.11, 0.04). While did not find stillbirth, associations noted under specific conditions, such as IAP, designs, analyses. Further research needed clarify these associations.

Language: Английский

Citations

0
The association between periodontal disease and adverse pregnancy outcomes: a bibliometric analysis from 2000 to 2023 DOI Creative Commons

Miaomiao Zhao,

Hang‐Seok Chang,

Y Yue

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 21, 2025

Background Periodontal disease (PD) refers to a chronic inflammatory disorder affecting the supporting tissues of teeth triggered by bacterial infection and is recognized promote systemic inflammation, leading dysfunction in specific organs. Adverse pregnancy outcomes (APOs), including preterm birth, small for gestational age infants, diabetes preeclampsia, are linked complications. Recently, correlation between periodontal adverse has garnered global attention. However, bibliometric studies this area remain limited. This study aimed visualize knowledge framework research trends concerning relationship from 2000 2023 through approaches. Methods On September 22, 2024, articles reviews on connection were retrieved Web Science Core Collection (WOSCC). CiteSpace [6.3.R1 (64-bit) Advanced] was used perform mapping studies. Results Over past 23 years, 932 73 countries collected, with U.S. contributing over one-third (355), followed Brazil (85) India (59). The literature field experienced multiple growth phases since 2000, particularly rapid observed after 2019. University North Carolina ( n = 34, 3.65%) institution terms publication output, primarily representing Notably, Journal Periodontology American Obstetrics Gynecology most frequently cited journals fields periodontology obstetrics, respectively. These publications authored 94 researchers, Steven Offenbacher being both productive highly author, making significant contributions field. A visual analysis keywords identifies “oral microbiota,” health,” “adverse outcomes,” “global burden” as emerging hotspots exploring outcomes. Conclusions first offers concise overview suggests future should focus risk factors, high-risk populations, oral microbiota, mechanisms, interventions, international collaboration.

Language: Английский

Citations

0
Certolizumab pegol to prevent adverse pregnancy outcomes in patients with antiphospholipid syndrome and lupus anticoagulant (IMPACT): results of a prospective, single-arm, open-label, phase 2 trial DOI
D. Ware Branch, Mimi Kim, Marta Guerra

et al.

Annals of the Rheumatic Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Incorporating placental pathology into clinical care and research DOI
Drucilla J. Roberts, Omonigho Aisagbonhi, Mana M. Parast

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

1
The Importance of Gene Variants Related to Folate Uptake and Distribution in the Etiology of Recurrent Miscarriage and Intrauterine Fetal Demise DOI Creative Commons

Martyna Kozłowska-Wytyk,

Grażyna Kurzawińska, Marcin Ożarowski

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(24), P. 11847 - 11847

Published: Dec. 18, 2024

(1) Background: The study involves an assessment of the frequency selected gene variants related to folate uptake and distribution (FOLR1 rs2071010, rs630074, FOLH1 rs61886492, GGH rs11545078, rs3758149 SLC19A1 rs1051266) in a group women with fetal demise Polish population. (2) Methods: A total 310 subjects were enrolled study. There 110 females idiopathic recurrent miscarriages (RM), 80 stillbirth (IUFD) 120 healthy controls. Designated SNVs determined by using PCR-RFLP methods. difference prevalence was assessed chi-square test logistic regression analysis. (3) Results: rs630074 variant FOLR1 is associated statistically significant increase risk IUFD recessive model (OR = 2.03, 95%CI: 1.06–3.90, p 0.033). rs61886492variant f linked increased co-dominant (p 0.030), dominant 2.62, 1.07–6.38, 0.032) log-additive models 2.64, 1.15–6.06 0.030). In female carriers allele, 2.8 times higher compared control group. No relationship between mother’s genotype newborn’s birth weight or placental observed for studied SNVs. (4) Conclusions: Our finds that rs61886492 women. However, pregnancy failures have multifactorial pathology other genetic environmental factors may also contribute their complex etiology. Further research, preferably larger groups from different ethnic backgrounds, needed confirm results current

Language: Английский

Citations

1