A reproducible framework for monitoring the impact of randomized clinical trials on clinical practice using large-scale real-world data: application to gynaecological surgical trials using the French national healthcare database
EClinicalMedicine,
Journal Year:
2025,
Volume and Issue:
80, P. 103053 - 103053
Published: Jan. 7, 2025
Language: Английский
Minimally invasive surgery for simple hysterectomy in early-stage cervical cancer: ‘SHAPing’ a path forward.
International Journal of Gynecological Cancer,
Journal Year:
2024,
Volume and Issue:
35(1), P. 101619 - 101619
Published: Dec. 28, 2024
Language: Английский
ROCC/GOG-3043: A randomized controlled trial of robotic versus open surgery for early-stage cervical cancer
International Journal of Gynecological Cancer,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101760 - 101760
Published: Feb. 1, 2025
The
Laparoscopic
Approach
to
Cervical
Cancer
trial
is
the
only
randomized
date
addressing
role
of
surgical
approach
in
cervical
cancer;
however,
this
non-inferiority
minimally
invasive
surgery
vs
an
open
patients
undergoing
radical
hysterectomy
for
early-stage
cancer
did
not
meet
its
primary
end
point
4.5-year
disease-free
survival
and
was
terminated
early
because
significantly
worse
disease-specific
survival,
overall
locoregional
recurrence
cohort.
Our
compares
3-year
after
robotic-assisted
or
abdominal
simple
(in
select
cases)
cancer.
We
hypothesize
that
non-inferior
hysterectomy.
This
multi-center,
conducted
through
Gynecologic
Oncology
Group
has
specified
surgeon
qualification
criteria.
It
requires
a
pelvic
magnetic
resonance
imaging
scan
all
before
enrollment
will
use
1:1
randomization
assign
All
surgeons
must
tumor-containment
techniques
both
arms.
does
allow
trans-cervical
uterine
manipulators.
Patients
with
(2018
International
Federation
Gynecology
Obstetrics
stages
IA2-IB2)
Histologic
types
are
limited
squamous
cell
carcinoma,
adenocarcinoma,
adenosquamous
carcinoma.
Pelvic
confirm
tumor
4
cm
less
without
definitive
extra-cervical
spread.
A
allowed
cases
study
principal
investigator
review.
between
randomly
allocate
840
patients,
planned
interim
analysis
futility
(oncologic
safety)
we
have
allocated
370
640
patients.
2030.
ClinicalTrials.gov
identifier:
NCT04831580.
Language: Английский
Modified abdominal radical trachelectomy used to spare fertility during surgery for early-stage cervical cancer: a case report
Journal of Medical Case Reports,
Journal Year:
2024,
Volume and Issue:
18(1)
Published: Nov. 29, 2024
Cervical
cancer
is
the
fourth
most
common
malignant
tumor
in
childbearing-age
women.
To
date,
cervical
resection
and
fertility-sparing
surgery
are
trends
era
of
minimally
invasive
management.
However,
a
proper
management
remains
crucial.
Hereby,
we
endeavor
to
underscore
an
uncommon
case
early-stage
receiving
tailored
surgical
technique
abdominal
radical
trachelectomy
at
our
tertiary
referral
center
review
literature.
A
33-year-old
Vietnamese
female
patient
(E1)
was
hospitalized
for
diagnosis
classified
as
IB1
stage.
The
treated
with
modified
surgery.
postoperative
outcome
completely
favorable.
sent
home
after
5
days
hospitalization.
In
addition,
she
monitored
without
complications.
Fertility-preserving
treatment
could
be
effectively
performed
among
young
women
cancer.
Interdisciplinary
potentially
necessary
favorable
outcome.
Further
data
required
long-term
outcomes
pregnancy,
recurrent
rate,
risk
pelvic
organ
prolapse.
Language: Английский