International expert consensus on micronutrient supplement use during the early life course

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 20, 2025

Abstract Background Growing evidence demonstrates that maternal nutrition is crucial for the health of mother-to-be, and early life course offspring. However, most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate level expert consensus on micronutrient needs during preconception, pregnancy lactation. Methods We conducted a two-round web-based survey various topics including general approaches diet supplement use, existing guidelines. For periods lactation, questions focused importance strength use with following micronutrients low- high-risk populations: folic acid, choline, iodine, magnesium, calcium, iron, selenium, docosahexaenoic acid (DHA), vitamins B1, B2, B6, B12, D K. Results Thirty-five experts participated in panel, who were healthcare professionals (HCPs), researchers joint HCP-researchers expertise nutrition, gynaecology and/or obstetrics. Panellists reached dietary agreed lack clarity consistency current guidelines, need education these areas HCPs, pregnant people population. low-risk populations, there was iron vitamin from preconception through iodine second third trimesters, respectively, DHA first trimester lactation calcium each phases improve outcomes foetal development strong, except (preconception), (first trimester), (both periods). There also advice should be tailored vegan/vegetarian diets, restricted diets due food intolerances, obesity, polycystic ovary syndrome, diabetes mellitus, previous nutrition-related complications. Conclusion The findings revealed robust aspects education, across specific at-risk groups requiring approaches.

Language: Английский

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The science behind functional foods: unraveling the nutritional secrets

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 13 - 28

Published: Jan. 1, 2025

Language: Английский

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Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)—Should They Be Mandatory Supplements in Pregnancy?

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1471 - 1471

Published: July 3, 2024

Docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) are essential fatty acids for the human body. Seafood microalgae most important sources of omega-3 acids. Supplementation with 200 mg/day DHA during pregnancy breastfeeding has been suggested women infants in countries low seafood consumption. Maternal concentration EPA was associated cord blood breast milk. High concentrations were identified at level retinal photoreceptors neuronal cell membranes. It observed that supplementation had beneficial effects on neurological development fetus infant by improving language, memory, attention, hand coordination, affecting sleep patterns, visual acuity. Beneficial also maternal intake breastfeeding. may reduce risk preterm birth but preeclampsia low-risk pregnancies. Women childbearing age should have an 250 + from their diet or supplements. To premature birth, pregnant must additionally receive least 100–200 mg every day. is recommended starts before 20 weeks pregnancy. mother identified, such as reduction postpartum depression symptoms, decrease cardiovascular risk, anti-inflammatory role.

Language: Английский

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Omega-3 Long-Chain Polyunsaturated Fatty Acids in Nonseafood and Estimated Intake in the USA: Quantitative Analysis by Covalent Adduct Chemical Ionization Mass Spectrometry

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(27), P. 15311 - 15320

Published: June 29, 2024

Omega-3 long-chain polyunsaturated fatty acids (LCPUFA) play critical roles in human development and health. Their intake is often effectively estimated solely based on seafood consumption, though the high of terrestrial animal-based foods with minor amounts LCPUFA may be significant. Covalent adduct chemical ionization (CACI) tandem mass spectrometry one approach for de novo structural quantitative analysis unsaturated (FA), which standards are unavailable. Here, CACI-MS MS/MS used to identify quantify omega-3 animal application measured response factors (RFs) various FA. American mean intakes pork, beef, chicken, eggs contribute 20, 27, 45, 71 mg/day docosahexaenoic acid (DHA), respectively. The DHA, eicosapentaenoic acid, docosapentaenoic from nonseafood sources significant, at 164, 103, 330 mg/day, greater than most existing estimates intake.

Language: Английский

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Determinants of Maternal and Infant Omega-3 Status at 3 Months Postpartum: Findings from the APrON Longitudinal Cohort Study

American Journal of Clinical Nutrition, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Omega-3 long chain polyunsaturated fatty acids (LCPUFAs) are important dietary components for maternal and infant health during pregnancy lactation. This study investigated determinants of LCPUFAs status at three months postpartum the relationship between serum, mother's milk, LCPUFAs. cross-sectional included mothers (n=1481) their offspring (n=526) from APrON cohort. Maternal intake (24-hour recall), blood samples infants, milk were collected. Fatty acid composition (relative % total acids) was determined by gas-liquid chromatography. Linear regression analyses explored associations diet, sociodemographic factors, status. In a multivariable-adjusted analysis, (supplement + food) positively associated with percentage docosahexaenoic (DHA, standardized(S) ß=0.394; 95% CI: 0.192, 0.558; P<0.001) in serum phospholipids. Similar found DHA eicosapentaenoic plasma phospholipids infants. Pre-pregnancy body mass index (BMI) negatively (Sß=-0.073; ß=-0.003; -0.006, -0.001; P=0.008) saturated (Sß=0.086; ß=0.111; 0.042, 0.180; P=0.002) milk. Infants receiving formula combination had lower (Sß=-0.177; ß=-0.390; -0.604, -0.175; arachidonic (Sß=-0.106; ß=-0.595; -1.122, -0.067; P=0.027) compared to those who fed exclusively own pre-pregnancy BMI independently lactation, while composition, lactation n-3 Future research should investigate impact these differences on outcomes.

Language: Английский

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Benefits Of Omega-3 In Peruvian Anchoveta: A Review Of Its Impact On Health

Revista de Gestão Social e Ambiental, Journal Year: 2025, Volume and Issue: 19(1), P. e010808 - e010808

Published: Jan. 16, 2025

Objectives: The objective of the research was to analyze current state knowledge about Omega-3 in Peruvian anchovy understand its positive effects on health and promote adequate consumption. Theoretical framework: fatty acid present is widely known by scientific community, but information has not been disseminated enough know treatment inflammatory autoimmune diseases. Method: were explored from various perspectives, highlighting anti-inflammatory action potential prevention chronic Results discussion: anchovy, abundant sea economic for availability catch fishing fleet, offers an accessible alternative without compromising nutritional content, especially relevant regions with low economy where other sources are unreachable. It concluded that source considerable value. Consumption improves public preventing Implications research: Promote policies include maximize benefits society, vulnerable populations ensuring food security access low-cost animal protein. Originality/Value: essential accordance ecosystem approach applied fisheries, sustainable development goals. a rethinking dietary recommendations suggested, Peru.

Language: Английский

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The Impact of Long-chain Omega-3 polyunsaturated fatty acids (LCPUFA) Supplementation in Pregnant Women Towards the Intelligence Status of Early Childhood: Protocol for Systematic Review and Meta-Analysis (Preprint)

JMIR Research Protocols, Journal Year: 2025, Volume and Issue: 14, P. e60417 - e60417

Published: March 4, 2025

Background Long-chain omega-3 polyunsaturated fatty acids (LCPUFAs) are essential that protect cellular structures and provide energy, particularly for fetal growth development. The maternal supplementations of LCPUFA may affect the rate intelligence in early childhood Objective This systematic review aims to synthesize available evidence on impact supplementation during pregnancy toward development by analyzing outcomes specifying aspects such as neurodevelopment, social-emotional, language, attention, behavior, cognition, vision, hearing, motor skills. Methods We will only include randomized controlled trials pregnant women supplemented with interventions outcome measured is children’s intelligence. Based World Health Organization's definition childhood, we children aged 8 years or younger. Children’s can be indicated using several tools measuring their index, Irrelevant unavailable studies excluded. A search conducted 3 electronic databases, namely PubMed, Scopus, Cochrane relevant synonymous terms. Study screening selection authors based eligibility criteria. Upon encountering conflicting decisions, a discussion held reach consensus. process recorded PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) flowchart. included subjected bias quality assessment accordance Critical Appraisal Skills Programme (CASP) Grading Recommendations Assessment, Development, Evaluation (GRADE) tool trials. Results An initial was November 1, 2023, which returned 1998 screening. extracted data classified into groups subgroups according indicator study. Next, summarized tables evidence. Whenever possible, meta-analysis homogeneous statistical software RevMan (version 5.4; Collaboration). Studies significant heterogeneity discussed narratively. estimated published 2025. Conclusions systematically pool potential use improve status. also important addressing any existing knowledge gaps this topic. Finally, deeper understanding association between consumption aid policy makers, health care practitioners, mothers more informed evidence-based decisions. Trial Registration PROSPERO CRD42023463910; https://www.crd.york.ac.uk/PROSPERO/view/CRD42023463910 International Registered Report Identifier (IRRID) DERR1-10.2196/60417

Language: Английский

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Is Docosahexaenoic Acid Supplementation During Pregnancy and Lactation Beneficial for the Mother-Infant Dyad?

Indian Pediatrics, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

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Nutritional supplements in pregnancy: recommendations based on current evidence

Çukurova medical journal (Online)/Çukurova medical journal, Journal Year: 2025, Volume and Issue: 50(1), P. 241 - 249

Published: March 25, 2025

Among the many factors affecting outcome of pregnancy, nutrition expectant mother plays an important role. Malnutrition is sometimes manifested by nutrient deficiencies and over-nutrition. Another problem use non-nutrient products in hope supporting nutrition. While some these non-nutrients are produced licensed as medicines, a considerable number them marketed food supplements. The ingredients preparation methods supplements not strictly controlled those medicines. When recommending drug or product to patients, goal should be achieve concretely defined benefit. It enough simply assume that there will no harm substances already naturally present body. benefit/harm assessment substance used terms possible side effects, undesirable effects interactions taken into consideration. group question pregnant women, it kept mind differences physiology each week pregnancy needs growing fetus its resistance external also vary. In our article, we tried examine frequently used, recommended, prescribed expected positively affect outcomes evidence-based medicine. As result review, found only have been shown beneficial routine folic acid before first trimester iron throughout pregnancy. For other products, concluded valid provide education about importance balanced regular life. .

Language: Английский

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Harnessing Microalgae: Pioneering Strategies for Cost-Effective EPA Synthesis

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106687 - 106687

Published: April 1, 2025

Language: Английский

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