Fish consumption advice is depriving children of neurolipids and other nutrients essential to brain and eye development

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Omega-3 fatty acid supply in pregnancy for risk reduction of preterm and early preterm birth: A position statement by the European Board and College of Obstetrics and Gynaecology (EBCOG)

European Journal of Obstetrics & Gynecology and Reproductive Biology, Journal Year: 2024, Volume and Issue: 295, P. 124 - 125

Published: Feb. 6, 2024

Language: Английский

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Prediction and prevention of preterm birth: Quality assessment and systematic review of clinical practice guidelines using the AGREE II framework

International Journal of Gynecology & Obstetrics, Journal Year: 2024, Volume and Issue: 166(3), P. 932 - 942

Published: April 15, 2024

Prediction of pregnancies at risk preterm birth (PTB) may allow targeted prevention strategies.

Language: Английский

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Pre-pregnancy overweight or obesity moderates the association between prenatal maternal depressive symptoms and infant cord blood omega-3 levels

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 14, 2024

Abstract Background Empirical evidence has demonstrated associations between pre-pregnancy obesity and perinatal maternal depressive symptoms. Omega-3 is an essential fatty acid derived from dietary sources that critical for fetal brain development. Pre-pregnancy associated with higher omega-3 intake, but a weaker association intake respective cord blood levels. Further, lower of during pregnancy been linked to Yet, prior studies have not examined the interactive effects overweight or (OWOB) prenatal mental health symptoms on infant Methods Participants included 394 maternal-infant dyads NIH Environmental influences Child Health Outcomes (ECHO) - Safe Passage Study in South Dakota. A body mass index (BMI) > 25 was used dichotomize participants as OWOB (54%) vs. non-OWOB (46%). Prenatal were measured using Edinburgh Postnatal Depression Scale (EPDS) anxiety State-Trait Anxiety Inventory (STAI). We implemented linear regression models examine interaction term BMI category Secondary analyses stratified by category. Results observed significant (F(4,379) = 6.21, p < .0001, adj. R 2 0.05). Stratified revealed levels only among individuals (β -0.06, 95% CI -0.11, -0.02; F (2,208) 4.00, .05, adj 0.03). No participants. Conclusions Findings suggest maternal-placental transfer may represent one pathway which metabolic impacts

Language: Английский

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Nutraceuticals in Pregnancy: A Special Focus on Probiotics

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9688 - 9688

Published: Sept. 7, 2024

The placenta is crucial to fetal development and performs vital functions such as nutrient exchange, waste removal hormone regulation. Abnormal placental can lead conditions growth restriction, pre-eclampsia stillbirth, affecting both immediate long-term health. Placental a highly complex process involving interactions between maternal components, imprinted genes, signaling pathways, mitochondria, sexomes environmental factors diet, supplementation exercise. Probiotics have been shown make significant contribution prenatal health, health development, with associations reduced risk of preterm birth pre-eclampsia, well improvements in through effects on gut microbiota, lipid metabolism, vaginal infections, gestational diabetes, allergic diseases inflammation. This review summarizes key studies the influence dietary focus role probiotics development.

Language: Английский

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Fetal dependency on maternal fatty acids: a pilot study in human pregnancies using the natural abundance variation of ¹³C

British Journal Of Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Dec. 16, 2024

Abstract The extent of de-novo biosynthesis non-essential fatty acids (FAs) and the endogenous long chain polyunsaturated FAs in human fetuses remains largely unknown. We used natural variations 13 C: 12 C (δ C) plasma phospholipids woman at delivery cord blood to infer fetal FAs. studied 39 mother-fetus pairs with uncomplicated pregnancies term delivery. Eighteen women were supplemented docosahexaenoic acid (DHA), from pregnancy week 20 until delivery, sourced an algae (n=13) or fish oil (n=5), each slightly different content. Twenty-one did not receive DHA supplementation. measured δ value selected phospholipid (C16:0, C18:0, C18:1n-9, C18:2n-6, C20:4n-6, C22:6n-3), maternal samples using isotope ratio mass spectrometry. found significant linear correlations for values between mothers their r=0.8535; r=0.9099; r=0.8079; r=0.9466; r=0.9257; C22:6n-3, r=0.9706). Women algal had significantly lower than those who supplementation (p<0.001). There was no difference fetuses. These findings strongly suggest that fetus is highly dependent on placental transport FAs, particularly DHA. limited major emphasizes crucial role nutrition well-being development.

Language: Английский

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A follow-up from a randomized controlled trial suggests that fish oil in pregnancy may increase the risk of obesity and metabolic syndrome in the offspring—a reason for concern?

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 119(4), P. 863 - 864

Published: Feb. 22, 2024

Language: Английский

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Pre-pregnancy overweight or obesity moderates the association between prenatal maternal depression and infant cord blood omega-3 levels

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 9, 2024

Background Empirical evidence has demonstrated associations between pre-pregnancy obesity and perinatal maternal depressive symptoms. Omega-3 is an essential fatty acid derived from dietary sources that critical for fetal brain development. Pre-pregnancy associated with higher omega-3 intake, but a weaker association intake respective cord blood levels. Further, lower of during pregnancy been linked to Yet, prior studies have not examined the interactive effects overweight or (OWOB) prenatal depression on infant Methods Participants included 394 maternal-infant dyads NIH Environmental influences Child Health Outcomes (ECHO) - Safe Passage Study in South Dakota. A body mass index > 25 was used dichotomize participants as OWOB (54%) vs. non-OWOB (46%). Prenatal symptoms were measured using Edinburgh Postnatal Depression Scale (EPDS) anxiety State-Trait Anxiety Inventory (STAI). We implemented linear regression models examine interaction term levels controlling preterm birth. Secondary analyses stratified by status. Results observed significant (F (4,379) = 6.21, p < .0001, adj. R² 0.05). Stratified revealed only among individuals OWOB, there (β -0.06, 95% CI -0.11, -0.02; F (2,208) 4.00, .05, adj 0.03). No participants. Conclusions Findings suggest maternal-placental transfer may represent one pathway which metabolic mental health impacts

Language: Английский

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DHA supplementation for early preterm birth prevention: An application of Bayesian finite mixture models to adaptive clinical trial design optimization

Contemporary Clinical Trials, Journal Year: 2024, Volume and Issue: 144, P. 107633 - 107633

Published: July 14, 2024

Early preterm birth (ePTB) - born before 34 weeks of gestation poses a significant public health challenge. Two randomized trials indicated an ePTB reduction among pregnant women receiving high-dose docosahexaenoic acid (DHA) supplementation. One them is Assessment DHA on Reducing Preterm Birth (ADORE). A survey employed in its secondary analysis identified with low levels, revealing that they derived greater benefits from This survey's inclusion future can provide critical insights for informing clinical practices.

Language: Английский

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Psychological disorders and omega-3s

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 175 - 193

Published: Sept. 6, 2024

Language: Английский

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