Frontiers in Neuroscience,
Journal Year:
2024,
Volume and Issue:
18
Published: Dec. 13, 2024
Background
Autism
spectrum
disorder
is
a
distinctive
developmental
condition
which
caused
by
an
interaction
between
genetic
vulnerability
and
environmental
factors.
Biomarkers
play
crucial
role
in
understanding
disease
characteristics
for
diagnosis,
prognosis,
treatment.
This
study
employs
bibliometric
analysis
to
identify
review
the
100
top-cited
articles’
characteristics,
current
research
hotspots
future
directions
of
autism
biomarkers.
Methods
A
comprehensive
search
biomarkers
studies
was
retrieved
from
Web
Science
Core
Collection
database
with
combined
keyword
strategy.
top
articles
conducted
CiteSpace,
VOSviewer,
Excel,
including
citations,
countries,
authors,
keywords.
Results
The
cited
were
published
1988
2021,
United
States
led
productivity.
such
as
genetics,
children,
oxidative
stress,
mitochondrial
dysfunction
are
well-established.
Potential
trends
may
include
brain
studies,
metabolomics,
associations
other
psychiatric
disorders.
Conclusion
pioneering
provides
compilation
most-cited
on
autism,
not
only
offers
valuable
resource
doctors,
researchers
but
shedding
insights
into
shortcomings
endeavors.
Future
should
prioritize
application
emerging
technologies
biomarkers,
longitudinal
specificity
advance
precision
ASD
diagnosis
Asian Journal of Psychiatry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 104498 - 104498
Published: April 1, 2025
Integrating
data
science
techniques,
including
machine
learning,
natural
language
processing,
and
big
analytics,
has
revolutionized
the
diagnosis
intervention
landscape
for
Autism
Spectrum
Disorder
(ASD).
This
rapid
review
examines
these
approaches'
current
applications,
benefits,
limitations,
ethical
considerations
while
identifying
key
research
gaps
future
directions.
Data-driven
methodologies
offer
significant
advantages,
such
as
enhanced
diagnostic
accuracy,
personalized
interventions,
increased
accessibility,
particularly
in
resource-limited
settings.
However,
challenges
like
quality,
algorithmic
bias,
interpretability
hinder
widespread
implementation.
Additionally,
concerns
regarding
privacy,
consent,
equity
necessitate
careful
navigation.
Despite
advancements,
substantial
remain,
lack
of
diverse
datasets,
limited
longitudinal
studies,
insufficient
generalizability
across
populations.
Future
studies
must
prioritize
addressing
by
fostering
collaboration,
ensuring
transparency,
developing
inclusive,
scalable
solutions
to
improve
patient
outcomes.
underscores
transformative
potential
accelerating
ASD
care
emphasizing
need
continued
innovation
responsible
application.
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
18
Published: Jan. 15, 2025
Over
the
last
three
decades,
dynamically
evolving
research
using
novel
technologies,
including
virtual
environments
(VEs),
has
presented
promising
solutions
for
neuroscience
and
neuropsychology.
This
article
explores
known
potential
benefits
drawbacks
of
employing
modern
technologies
diagnosing
treating
developmental
disorders,
exemplified
by
autism
spectrum
disorder
(ASD).
ASD's
complex
nature
is
ideal
illustrating
advantages
disadvantages
digital
world.
While
VEs'
possibilities
remain
under-explored,
they
offer
enhanced
diagnostics
treatment
options
ASD,
augmenting
traditional
approaches.
Unlike
real-world
obstacles
primarily
rooted
in
social
challenges
overwhelming
environments,
these
provide
unique
compensatory
opportunities
ASD-related
deficits.
From
our
perspective
addition
to
other
recent
work,
should
be
adapted
suit
specific
needs
individuals
with
ASD.
Indus journal of bioscience research.,
Journal Year:
2025,
Volume and Issue:
3(2), P. 199 - 212
Published: Feb. 25, 2025
Alzheimer's
Disease
(AD)
is
a
neurodegenerative
disorder
requiring
early
detection.
This
study
compares
AI
models—Convolutional
Neural
Networks
(CNN),
Support
Vector
Machines
(SVM),
and
Random
Forest
(RF)—in
analyzing
neuroimaging
data
(MRI,
PET)
to
enhance
AD
prediction
improve
diagnosis
using
machine
learning
techniques.
Through
the
application
of
multi-modal
in
form
genetic,
clinical,
data,
also
investigates
effectiveness
combining
different
types
predictability
models
for
diagnosis.
Feature
importance
analysis
was
performed
methods
like
SHAP
(SHAP
(Shapley
Additive
Explanations)
values
determine
most
important
variables
model
predictions,
e.g.,
certain
brain
regions
or
genetic
components.
The
generalizability
real-world
applicability
by
training
on
an
independent
dataset
representing
diverse
clinical
settings.
performance
each
assessed
variety
statistical
measures
accuracy,
precision,
recall,
F1-score,
Area
Under
Curve
(AUC).
findings
showed
that
CNN
better
compared
SVM
RF
all
metrics
with
highest
accuracy
(92%),
precision
(93%),
recall
(91%),
AUC
(0.95).
suggest
effectively
detects
subtle
patterns,
making
it
strong
tool
While
well,
superior
accuracy.
Cross-validation
confirmed
its
generalizability,
crucial
use.
Implementing
models,
especially
CNN,
may
enable
earlier
detection,
timely
interventions,
improved
patient
outcomes
Alzheimer’s
care.
References
Electronics,
Journal Year:
2025,
Volume and Issue:
14(5), P. 951 - 951
Published: Feb. 27, 2025
This
study
provides
a
comprehensive
analysis
of
the
evolution
Autism
Spectrum
Disorder
(ASD)
diagnostics,
tracing
its
progression
from
psychoanalytic
origins
to
integration
advanced
artificial
intelligence
(AI)
technologies.
The
explores,
through
scientific
data
bases
like
Pub
Med,
Scopus,
and
Google
Scholar,
how
theoretical
frameworks,
including
psychoanalysis,
behavioral
psychology,
cognitive
development,
neurobiological
paradigms,
have
shaped
diagnostic
methodologies
over
time.
Each
paradigm’s
associated
assessment
tools,
such
as
Diagnostic
Observation
Schedule
(ADOS)
Vineland
Adaptive
Behavior
Scales,
are
discussed
in
relation
their
advancements
limitations.
Emerging
technologies,
particularly
AI,
highlighted
for
transformative
impact
on
ASD
diagnostics.
application
AI
areas
video
analysis,
Natural
Language
Processing
(NLP),
biodata
demonstrates
significant
progress
precision,
accessibility,
inclusivity.
Ethical
considerations,
algorithmic
transparency,
security,
inclusivity
underrepresented
populations,
critically
examined
alongside
challenges
scalability
equitable
implementation.
Additionally,
neurodiversity-
informed
approaches
emphasized
role
reframing
autism
natural
variation
human
cognition
behavior,
advocating
strength-based,
inclusive
frameworks.
synthesis
underscores
interplay
between
evolving
models,
technological
advancements,
growing
focus
compassionate,
practices.
It
concludes
by
continued
innovation,
interdisciplinary
collaboration,
ethical
oversight
further
refine
diagnostics
improve
outcomes
individuals
across
spectrum.
Computers,
Journal Year:
2025,
Volume and Issue:
14(3), P. 86 - 86
Published: Feb. 28, 2025
The
accurate
segmentation
of
3D
spheroids
is
crucial
in
advancing
biomedical
research,
particularly
understanding
tumor
development
and
testing
therapeutic
responses.
As
emulate
vivo
conditions
more
closely
than
traditional
2D
cultures,
efficient
methods
are
essential
for
precise
analysis.
This
study
evaluates
three
prominent
neural
network
architectures—U-Net,
HRNet,
DeepLabV3+—for
the
spheroids,
a
critical
challenge
image
Through
empirical
analysis
across
comprehensive
Tumour
Spheroid
dataset,
HRNet
DeepLabV3+
emerged
as
top
performers,
achieving
high
accuracy,
with
99.72%
validation
Dice
coefficient
96.70%,
Jaccard
93.62%.
U-Net,
although
widely
used
medical
imaging,
struggled
to
match
performance
other
models.
also
examines
impact
optimizers,
Adam
optimizer
frequently
causing
overfitting,
especially
U-Net
Despite
improvements
SGD
Adagrad,
these
optimizers
did
not
surpass
DeepLabV3+.
highlights
importance
selecting
right
model–optimizer
combination
optimal
segmentation.
Neuroglia,
Journal Year:
2025,
Volume and Issue:
6(1), P. 11 - 11
Published: March 1, 2025
Background/Objectives:
Autism
Spectrum
Disorder
(ASD)
is
a
complex
neurodevelopmental
condition
marked
by
challenges
in
social
communication,
restricted
interests,
and
repetitive
behaviors.
Recent
studies
highlight
the
crucial
roles
of
neuroglial
cells—astrocytes,
microglia,
oligodendrocytes—in
synaptic
function,
neural
connectivity,
neuroinflammation.
These
findings
offer
fresh
perspective
on
ASD
pathophysiology.
This
review
synthesizes
current
knowledge
dysfunction
ASD,
emphasizing
its
role
pathophysiological
mechanisms,
genetic
influences,
potential
therapeutic
strategies.
Methods:
We
conducted
comprehensive
literature
review,
integrating
insights
from
neuroscience,
molecular
biology,
clinical
studies.
Special
focus
was
given
to
glial-mediated
neuroinflammatory
plasticity
regulation,
impact
mutations
signaling
homeostasis.
Results:
Neuroglial
evident
abnormal
pruning
impaired
astrocytic
glutamate
defective
oligodendrocyte-driven
myelination,
which
collectively
disrupt
neuronal
architecture.
Emerging
therapies
targeting
these
pathways,
including
anti-inflammatory
drugs,
microglial
modulators,
cell-based
approaches,
show
promise
alleviating
key
symptoms.
Additionally,
advanced
interventions
such
as
gene
editing
glial
progenitor
therapy
present
opportunities
correct
underlying
dysfunction.
Conclusions:
establishes
framework
for
understanding
contributions
ASD.
By
diverse
disciplines,
it
enhances
our
pathophysiology
paves
way
novel
strategies
pathways.