Morphine's role in macrophage polarization: Exploring M1 and M2 dynamics and disease susceptibility

Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: 400, P. 578534 - 578534

Published: Jan. 23, 2025

Language: Английский

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Endogenous opiates and behavior: 2023

Peptides, Journal Year: 2024, Volume and Issue: 179, P. 171268 - 171268

Published: June 28, 2024

Language: Английский

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Opioid System and Epithelial–Mesenchymal Transition

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 120 - 120

Published: Jan. 17, 2025

Opioids are a challenging class of drugs due to their dual role. They alleviate pain, but also pose risk dependency, or trigger constipation, particularly in cancer patients, who require the more potent painkillers advanced stages disease, closely linked pain resulting from general inflammation, bone metastases, and primary secondary tumour outgrowth-related nerve damage. Clinicians' vigilance considering treatment with opioids is necessary, bearing mind extensive data accumulated over decades that have reported contribution immunosuppression, progression, impaired tissue regeneration, either following opioid use during surgical resection post-surgical treatment, as result other diseases like diabetes, where chronic wounds healing constitutes challenge. During last few years, an increasing trend for seeking relationships between epithelial-mesenchymal transition (EMT) research can be observed. Transiently lasting EMT desirable wound healing, cancer, vital organ fibrogenesis, appears obstacle overcome, forcing adjust strategies would reduce worsening disease outcome patient prognosis. The same may demonstrate promoting inhibitory effect on EMT, dependently various conditions particular clinical cases. We summarized current findings this issue uncover some rules govern opioid-mediated induction repression; however, many aspects still remain elucidated.

Language: Английский

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CCTα and GVI iPLA2-induced aberrant phosphatidylcholine metabolism contributes to pulmonary inflammation and fibrosis

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114718 - 114718

Published: April 25, 2025

Language: Английский

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Rise of Macaque Models for Immunity and Infection Research

NeuroImmune Pharmacology and Therapeutics, Journal Year: 2024, Volume and Issue: unknown, P. 71 - 91

Published: Jan. 1, 2024

Language: Английский

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