Does a multimedia education program work as a remedy for stress and burden in family caregivers of elderly heart attack patients? A clinical trial study

BMC Nursing, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 6, 2025

Supportive care has been found to improve quality of life and reduce the disease burden for aging individuals. After a heart attack, elderly patients often require caregiver. In developing communities, caregiving responsibilities frequently fall on family members. Accordingly, we designed randomized controlled clinical trial assess effect an educational program perceived stress among caregivers attack patients. this (IRCT20220905055894N1, 01/02/2023), member were study participants, assigned either intervention or control groups using simple random sampling method. The group received only routine in-home information, without additional nurse training support, whereas multimedia-based training, monitoring, communication support from trained over one month. Perceived levels measured Stress Scale (PSS) Caregiving Burden Inventory, respectively. Before intervention, high level (34.07 ± 8.61 in vs. 34.17 8.62 group) (77.7 15.51 79 15.6 was observed. month average scores remained unchanged group, showed significant reduction (P < 0.001). inter-group comparison revealed lower A brief multimedia education could help alleviate stressful conditions experienced by Future studies investigate whether more extended would have lasting effects.

Language: Английский

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Exploring the Causal Relationship between Estimated Glomerular Filtration Rate and Cardiovascular Disease Outcomes Based on Mendelian Randomization

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1441 - 1449

Published: Jan. 1, 2025

Language: Английский

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Weight and cardiometabolic effects of a novel oral shape-shifting superabsorbent hydrogel capsule: Prespecified and exploratory analysis of the Epitomee capsule RESET Study.

Obesity Pillars, Journal Year: 2025, Volume and Issue: 13, P. 100163 - 100163

Published: Jan. 31, 2025

Management of obesity potentially improves cardiometabolic risk factors in patients with metabolic syndrome (MetS). The Epitomee capsule is a non-pharmacological, biodegradable device treatment for weight reduction overweight and obesity. This secondary analysis the Randomized Evaluation Safety Efficacy Trial (RESET) (a randomized, 24-week, multicenter, placebo-controlled, double-blind trial that enrolled 279 adults aged ≥18 years BMI 27-40 kg/m2) evaluated changes parameters participants treated or placebo combined lifestyle counseling among (a) entire RESET study population, (b) meeting diagnostic criteria prediabetes. Predefined exploratory endpoints included waist circumference, glycemic parameters, blood pressure, lipid levels; this also assessed percent loss MetS. Waist systolic diastolic pressure some measures glycemia lipids, improved both no significant differences. Participants prediabetes showed significantly greater reductions HOMA-IR (p < 0.007) insulin levels 0.003) than group. MetS at baseline experienced change initial when (n = 27) compared to 31), -8.3% vs -5.2 %, respectively 0.0004). Similar percentages groups achieved ≥5 % (59.3 54.8 respectively). Significantly more ≥10 those (40.7 vs. 6.5 respectively, p 0.002). Treatment either improve factors. Compared placebo, reduced Among MetS, body [ClinicalTrials.gov ID NCT04222322].

Language: Английский

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The Role of Functional Beverages in Mitigating Cardiovascular Disease Risk Factors: A Focus on Their Antidiabetic and Hypolipidemic Properties

Beverages, Journal Year: 2025, Volume and Issue: 11(1), P. 21 - 21

Published: Feb. 3, 2025

The incidence and mortality rates of cardiovascular diseases (CVDs) are constantly increasing. Among the main risk factors, diabetes mellitus hyperlipidaemia, which equally widespread pathological conditions, stand out. Current preventive strategies based on physical activity a healthy, balanced diet. Primary therapies, other hand, administration hypoglycaemic cholesterol-lowering drugs. Given increasing consumer demand for food products with healthy properties, functional beverages may represent breakthrough in this field. Through careful analysis studies conducted over past seven years, it has emerged that herbal teas, fruit vegetable drinks, as well milk- plant-based beverages, can mitigate these two critical CVD often linked to presence specific polyphenols or fermentation processes. selection vivo, vitro clinical trials revealed ability such drinks reduce enzymatic α-glucosidase α-amylase, decrease circulating lipid levels, properties were surprisingly also exhibited by derived from waste. Therefore, review aims highlight possibility employing adjuvant therapy treatment hyperlipidaemia order potential factors.

Language: Английский

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Artificial Intelligence and Machine Learning-Based Prediction of Cardiovascular Disease Risk in Rural Elderly Women in North-East India: Insights into Women's Health, HDL, Metabolic Syndrome, and Key Biomarkers

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Background: This study aimed to leverage artificial intelligence and machine learning approaches predict cardiovascular disease (CVD) risk among rural postmenopausal women in North-East India. The objectives included identifying critical factors evaluating the performance of various models enhance CVD prediction accuracy populations. Methods: research was conducted Singur Block (West Bengal) Amdanga (North 24 Parganas District) over a span four years, from March 2014 August 2018. Key factors, including waist circumference, blood pressure, fasting glucose, HDL cholesterol, were collected analyzed. A correlation matrix employed assess associations between these variables risk. Additionally, eight deployed risk, with comparisons identify most effective algorithm. Results: analysis revealed strong such as cholesterol playing lesser yet relevant role. Among tested, Random Forest algorithm achieved highest 98.91%, followed by Decision Tree Support Vector Classifier (SVC), both which accuracies exceeding 95%. Feature important highlighted circumference significant predictor, pressure glucose also contributing substantially while had comparatively lower but still notable impact. Conclusion: Machine techniques, particularly model, demonstrated remarkable efficacy predicting women. identifies key predictors, emphasizing potential learning-based cost-effective, scalable solutions for early detection. These findings provide foundation targeted preventive measures improved health outcomes underserved settings.

Language: Английский

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Bempedoic Acid for Prevention of Cardiovascular Events in People With Obesity: A CLEAR Outcomes Subset Analysis

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Background Obesity and hypercholesterolemia independently increase cardiovascular disease risk. This analysis evaluated the efficacy safety of bempedoic acid in people with obesity participating CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACL‐Inhibiting Regimen) Outcomes trial. Methods randomized 13 970 patients to daily 180 mg or placebo. Exploratory outcomes including major adverse events‐4 (cardiovascular death, nonfatal myocardial infarction, stroke, coronary revascularization), low‐density lipoprotein cholesterol, hs‐CRP (high‐sensitivity C‐reactive protein), weight change, were assessed over a median 40.7 months 6177 baseline body mass index ≥30 kg/m 2 . Results In obesity, resulted placebo‐corrected reductions cholesterol −22.5% −23.2% at 6 months. treatment reduction 23% (hazard ratio [HR], 0.77 [95% CI, 0.67–0.89]) versus Nonfatal fatal MI reduced by 32% (HR, 0.68 0.53–0.86]), revascularization was 24% 0.76 0.63–0.92]), stroke 36% 0.64 0.45–0.89]) compared At month 36, mean±SD change from −2.3 (6.3) kg for −1.4 (6.1) Adverse events reported 87.4% 86.7% placebo patients. The uric 0.81 (1.26) mg/dL −0.04 (1.05) Conclusions Among events, hs‐CRP, profile consistent previous reports. Registration URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT02993406.

Language: Английский

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Post-traumatic stress disorder, metabolic syndrome, diabetic distress, and vitamin B1/benfotiamine

INTERNATIONAL NEUROLOGICAL JOURNAL, Journal Year: 2025, Volume and Issue: 21(1), P. 96 - 107

Published: March 20, 2025

A person with post-traumatic stress disorder (PTSD) is more likely to develop metabolic syndrome (MetS), depression, and diabetic distress. It also raises the risk of cardiometabolic neurodegenerative diseases (NDD). At same time, type 2 diabetes mellitus MetS can cause development core neurosis-like psychiatric symptoms characteristic PTSD. Chronic associated cardiovascular diseases, diabetes, NDD. More people think that mitochondrial dysfunction, peripheral/central chronic low-grade inflammation (CLGI), oxidative are main causes these diseases. Pathophysiological processes link them together. To make things better for patients, interventions aim control CLGI may be better, following ideas precision medicine. Deficiency certain biofactors, in particular, vitamin B1, an increased MetS, Targeted effects on CLGI, stress, metabolism disorders suggest use antioxidants, particularly B1/benfotiamine (BFT), have a positive effect not only course comorbid but manifestations Exogenous or BFT, corrects thiamine status disorders. BFT exhibits potent animal models NDD, stress-induced anxiety, aggression, depression. Thus, considered potentially safe cost-effective drug treatment many central nervous system Despite its aspects, therapeutic potential remains limited, as beneficial require high doses over long period time. Dibenzoylthiamine, lipophilic form has been shown anti-inflammatory antioxidant at much lower than both vitro vivo. However, preclinical clinical studies needed sure viability dibenzoylthiamine. This review pays extra attention analysis features biological role mechanism action, especially impact glucose function, state neuroinflammation, how dibenzoylthiamine protect neurons. We conducted search Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. The keywords used were “thiamine”, “benfotiamine”, “dibenzoylthiamine”, “post-traumatic disorder”, “metabolic syndrome”, “diabetic distress”, “diabetes mellitus”. manual bibliography publications pinpoint research results eluded online search.

Language: Английский

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Association of the “life’s crucial 9” cardiovascular health with all-cause and cardiovascular disease mortality: a national cohort study

Archives of Public Health, Journal Year: 2025, Volume and Issue: 83(1)

Published: April 28, 2025

In 2022, the American Heart Association launched an updated algorithm for quantifying cardiovascular health (CVH), termed Life's Essential 8 (LE8). This new approach has been shown to be associated with various noncommunicable chronic diseases and mortality. However, LE8 did not take into consideration importance of psychological on CVH. Recently, a perspective article proposed Crucial 9 (LC9), which would add as another component LE8, novel metric assess study aims investigate association LC9 all-cause disease (CVD) included 23,080 adults from National Health Nutrition Examination Survey 2005-2018, mortality was ascertained by linkage Death Index records through 31 December 2019. The scoring categorized low (0-49), moderate (50-79), high (80-100) Weighted Cox proportional hazards regression models restricted cubic spline analysis were applied evaluate During median follow-up 7.8 years, total 2,388 overall deaths identified, covering 613 CVD deaths. Compared CVH score, those score had 52% (hazard ratio, 0.48; 95% confidence interval, 0.38-0.60) 64% (0.36; 0.23-0.56) reduced risk Similarly, 33% (0.67; 0.58-0.78) 49% (0.51; 0.40-0.64) population-attributable fractions vs. or 46.0% 75.8% Elevated blood lipids, body mass index, poor sleep quality three major contributors mortality, whereas nicotine exposure, unhealthy psychology, elevated lipids significant ones There approximately negative linear dose-response relationships Adhering is related definition shows promise primordial preventive strategy reduce rates.

Language: Английский

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Associations Between Physical Capability Markers and Risk of Coronary Artery Disease: A Prospective Study of 439,295 UK Biobank Participants

Healthcare, Journal Year: 2025, Volume and Issue: 13(9), P. 1018 - 1018

Published: April 28, 2025

Background: The relationship between sarcopenia and the incidence of coronary artery disease (CAD) is not well understood. This study aimed to investigate this modifying effect potential risk factors. Methods: We conducted a prospective including 439,295 individuals from UK Biobank. primary outcome was CAD. main physical capability markers for sarcopenia, grip strength muscle mass, were investigated as factors interest. Grip measured using Jamar J00105 (Lafayette, IN, USA) hydraulic hand dynamometer, while mass estimated through bioelectrical impedance. Cox proportional hazard models employed analyze associations exposures Results: A total 41,564 incident cases CAD identified after median follow-up 13.15 years (IQR 12.29–13.88 years). Compared with lowest quintile strength, adjusted HRs incidences second fifth 0.81 (95% CI: 0.79–0.83), 0.71 0.69–0.73), 0.61 0.60–0.63), 0.49 0.48–0.51). association remained significant in subgroup analysis interactions observed two sex, age, smoking status, inflammatory diseases, metabolic syndrome, genetic predisposition (all p < 0.05). Conclusions: Physical independently associated dose–response decreased incidence, regardless

Language: Английский

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Interactions Between Sedentary Behaviour, Moderate‐Vigorous Intensity Physical Activity and Acute Psychological Stress‐Induced Inflammatory Responses

Stress and Health, Journal Year: 2025, Volume and Issue: 41(3)

Published: May 2, 2025

ABSTRACT Psychological stress, physical activity (PA) and sedentary behaviour (SB) are modifiable risk factors for cardiovascular disease (CVD), possibly through altering one's inflammatory profile. The links between responses to acute psychological stress habitual moderate‐vigorous (MVPA) levels SB volume is not clear. We explored the relationships in magnitude of passive active with MVPA levels. Eighty‐eight healthy participants completed this study. Habitual were measured over 1 week using wearable devices. main trial consisted a baseline period, 6‐min (International Affective Picture System: IAPS) an 8‐min task (Paced Auditory Serial Addition Test: PASAT) 45‐min rest post‐tasks. Heart rate (HR), systolic blood pressure (SBP) diastolic (DBP) throughout testing protocol. Blood samples collected after each time point measure circulating lipopolysaccharide (LPS)‐stimulated interleukin‐6 (IL‐6), systemic inflammation response index (SIRI) neutrophil:lymphocyte ratio (NLR). There was significant positive relationship changes HR during IAPS ( B = 1.061; p 0.008). no change SBP or DBP (all > 0.05). stress‐induced IL‐6, LPS‐stimulated NLR SIRI This first study investigate context builds on previous work relation stress. found associations young adults, but since our very lean (21.7% body fat), findings may differ other populations.

Language: Английский

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