Triglycerides and metabolic syndrome: from basic to mechanism – A narrative review DOI
Gayathri S. Prabhu, Preethi Lavina Concessao

Archives of Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 14, 2024

The impact of triglyceride levels is important to understand the changes in metabolism and structure. With an increase obesity hyperlipidemia due diet; cardiovascular neuronal structural have been shown be more distinct.

Language: Английский

Fibroblast growth factor 21: a novel link in the development and treatment of metabolic disorders DOI Open Access
A. A. Mikhailova,

Marina V. Sharypova,

А. В. Симаненкова

et al.

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2025, Volume and Issue: 30(5), P. 441 - 450

Published: Jan. 21, 2025

In recent years, fibroblast growth factor 21 (FGF21) has garnered increasing attention as a metabolic regulator. It plays role in the development of tissue insulin sensitivity, exerts beneficial effects on carbohydrate and lipid metabolism, exhibits antihyperglycemic antilipidemic properties. Elevated FGF21 levels have been observed patients with type 2 diabetes, obesity, non-alcoholic fatty liver disease, range other conditions. This may indicate either resistance to or compensatory response stress. Evidence suggests that can be considered both marker several disorders potential therapeutic agent for treatment significant societal health issues. Objective . The objective this review is summarize data published date literature, including meta-analyses, reviews, original studies, focusing diagnostic disorders.

Language: Английский

Citations

0
Design and Rationale of the CORE –TIMI 72a and CORE2 –TIMI 72b Trials of Olezarsen in Patients with Severe Hypertriglyceridemia DOI Creative Commons
Nicholas Marston, Brian A. Bergmark, Veronica J. Alexander

et al.

American Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Hypertriglyceridemia — current status of the problem. Part II: primary and secondary hypertriglyceridemias, treatment options DOI Creative Commons

А. А. Семенкин,

А. Н. Мешков, М. В. Ежов

et al.

Russian Journal of Cardiology, Journal Year: 2025, Volume and Issue: 30(2), P. 6240 - 6240

Published: March 15, 2025

Hypertriglyceridemias are a heterogeneous group of pathologies differing in the mechanisms triglyceride-rich lipoprotein increase, composition lipoproteins and related risks. This review article presents information on profile pathogenesis various primary secondary hypertriglyceridemias, as well describes current potential genetic diagnostics, drug non-drug correction.

Language: Английский

Citations

0
Strategies to Address the Metabolic Burden of Psychotropic Medications DOI Creative Commons
Angelina Anthamatten, Queen Henry-Okafor

The Journal for Nurse Practitioners, Journal Year: 2025, Volume and Issue: 21(4), P. 105346 - 105346

Published: March 19, 2025

Language: Английский

Citations

0
A Qualitative Study to Explore the Patient Experience of Hypertriglyceridemia-related Acute Pancreatitis DOI
Asia Sikora Kessler, Daniel Aggio,

Ellen Howard

et al.

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Probiotics may be useful for drug-induced liver dysfunction in patients with depression – A secondary analysis of a randomized clinical trial DOI Creative Commons
Oliwia Gawlik-Kotelnicka,

Jacek Burzyński,

Jakub Rogalski

et al.

Clinical Nutrition ESPEN, Journal Year: 2024, Volume and Issue: 63, P. 604 - 614

Published: July 30, 2024

There is a need to identify new treatment options for depression with its comorbidities. Depression often coexists liver steatosis and the two may share pathophysiological overlap, including inflammation microbiota changes. Probiotics might represent safe option as an adjunctive therapy in patients possible steatosis. The paper presents secondary analysis of clinical trial effect probiotic supplementation on levels non-invasive markers fibrosis adult depressive disorders.

Language: Английский

Citations

2
Effect of chia seeds or concentrated fish oil on cardiometabolic risk markers in subjects with hypertriglyceridaemia: a parallel clinical trial DOI

Mohammad Reza Shahparvari,

Javad Nasrollahzadeh

Journal of Human Nutrition and Dietetics, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Background The beneficial effects of n‐3 polyunsaturated fatty acids (PUFA) in reducing high blood triglyceride (TG) levels have been well demonstrated. This study aimed to investigate the effect chia seeds on TG and its associated cardiometabolic factors hypertriglyceridaemic individuals. Methods three‐group randomised controlled trial compared a low‐calorie diet ( n = 22), with (30 g/day, 22) or concentrated fish oil (1.8 g/day long‐chain PUFAs, patients hypertriglyceridaemia. Anthropometrics, fasting lipids, proprotein convertase subtilisin/kexin type 9, insulin, adiponectin, leptin interleukin‐6 were measured. Results After 8 weeks, mean reduction weight exhibited by three groups was not statistically different (2.0, 2.7 2.8 kg, respectively, for control, seed groups). plasma decreased both comparison control group p 0.001). However, no significant difference observed between (change from baseline mean: 145.2 136.7 mg/dL groups, respectively). consumption diastolic pressure 8.4 mmHg) other two groups. No alterations biochemical Conclusions In people moderate hypertriglyceridaemia, 30 g supplements containing 1.8 PUFAs has similar levels, whereas it higher pressure–lowering effect.

Language: Английский

Citations

1
Triglyceride levels and remnant cholesterol triglyceride-rich lipoproteins in metabolic syndrome and diabetes DOI Creative Commons
Г. И. Симонова, Л. В. Щербакова, Sofia Malyutina

et al.

Ateroscleroz, Journal Year: 2024, Volume and Issue: 20(3), P. 326 - 344

Published: Oct. 2, 2024

In recent years, new epidemiological and genetic data have been obtained on the role of triglycerides (TG) remnant cholesterol (RC) triglyceride-rich lipoproteins in increasing residual risk atherosclerosis-associated cardiovascular diseases (ACCD) metabolic disorders. The aim study was to associations different levels RC triglyceriderich with syndrome (MS) type 2 diabetes mellitus (TDM2) Siberian population. Material methods. research carried out materials international project HAPIEE ( n = 9360 people) people aged 45–69 years. accordance protocol, a questionnaire, anthropometry, biochemical were conducted. Abdominal obesity (AO) found waist circumference ≥ 94 cm men 80 women. MS diagnosed according criteria IDF (2005), TDM2 – at fasting glucose 7.0 mmol/l (WHO, 1999, ADA, 2013), hypertriglyceridemia (hyperTG) definitions NCEP ATP III, 2002 Russian Clinical Guidelines lipid metabolism disorders, 2023. are calculated using formula: total (TC) HDL LDL mmol/L. triglyceride-glucose index (TyG) determined by TyG ln [Fasting (mg/dl) x Fasting (mg/dl)/2]. Results. Median values prevalence various TG (<1.7; 1.7 < 2.3; 2.3 5.6; 5.6 mmol/l). An increase has shown depending hyperTG. High AO, MS, revealed women: 0.68; 0.76; 0.90 0.79 0.93, respectively. 60 % women, 0.5 mmol/l. from 0.51–0.54 higher 1.26–1.29 frequency quintiles (Q) increases linearly Q1 Q5. It is that Q5 TyG, each subsequent quintile: 0.36–0.38 1.1–1.12 Conclusions . medians without disorders determined. mild moderate high hypertriglyceridemia.

Language: Английский

Citations

0
Triglycerides and metabolic syndrome: from basic to mechanism – A narrative review DOI
Gayathri S. Prabhu, Preethi Lavina Concessao

Archives of Physiology and Biochemistry, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: Nov. 14, 2024

The impact of triglyceride levels is important to understand the changes in metabolism and structure. With an increase obesity hyperlipidemia due diet; cardiovascular neuronal structural have been shown be more distinct.

Language: Английский

Citations

0