ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(45), P. 51200 - 51211
Published: Nov. 3, 2022
Prodrug-based
self-assembled
nanoparticles
combined
with
the
merits
of
nanotechnology
and
prodrugs
strategies
have
gradually
become
a
research
trending
topic
in
field
drug
delivery.
These
usually
consist
parent
drugs,
connecting
bonds,
modifying
chains.
The
influences
bonds
chains
on
pharmaceutical
characteristics,
vivo
delivery
fate,
antitumor
activity
prodrug
nanoassemblies
remain
elusive.
Herein,
three
docetaxel
(DTX)
were
designed
using
sulfur
(thioether
bond
or
disulfide
bond)
as
fatty
alcohols
(straight
chain
branched
chain)
Interestingly,
difference
between
deeply
influenced
colloidal
stability,
redox
responsive
release,
cytotoxicity,
pharmacokinetic
properties,
tumor
accumulation,
effect
nanoassemblies.
DTX
conjugated
via
(HUA-SS-DTX)
significantly
improved
efficiency
reduced
systematic
toxicity.
Our
study
elaborates
vital
role
rational
design
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
10(23)
Published: Oct. 4, 2021
Abstract
Prodrug
nanoassemblies
have
emerged
as
a
promising
platform
for
the
delivery
of
anticancer
drugs.
PEGylation
is
“gold
standard”
to
improve
colloidal
stability
and
pharmacokinetics
nanomedicines.
However,
clinical
application
PEG
materials
challenged
by
in
vivo
oxidative
degradation
immunogenicity.
Rational
design
advanced
biomaterials
surface
modification
nanomedicines
hot
spot
research.
Here,
zwitterionic
sulfobetaine
surfactant
constructed
novel
modifier
coassemble
with
10‐hydroxycamptothecin‐linoleic
acid
conjugate,
classical
PEGylated
material
control.
Interestingly,
both
type
ratio
surfactants
profound
impacts
on
molecular
mechanisms
assembly
prodrugs,
thereby
affecting
pharmaceutical
properties.
Compared
spherical
prodrug
nanoassemblies,
zwitterion‐modified
distinct
rod
shape
superhydrophilic
surface,
exhibit
potent
antitumor
activity
due
combination
multiple
advantages
terms
stability,
cellular
uptake,
pharmacokinetics.
The
findings
illustrate
crucial
role
determination
fate
pave
way
development
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
14(3), P. 1400 - 1411
Published: Sept. 30, 2023
The
self-assembly
prodrugs
are
usually
consisted
of
drug
modules,
activation
and
assembly
modules.
Keeping
the
balance
between
efficacy
safety
by
selecting
suitable
modules
remains
a
challenge
for
developing
prodrug
nanoassemblies.
This
study
designed
four
docetaxel
(DTX)
using
disulfide
bonds
as
different
lengths
branched-chain
fatty
alcohols
(C16,
C18,
C20,
C24).
determined
ability
affected
modules'
sensitivity.
extension
carbon
chains
improved
prodrugs'
pharmacokinetic
behavior
while
reducing
cytotoxicity
increased
cumulative
toxicity.
use
C20
can
safety.
These
results
provide
great
reference
rational
design
Fundamental Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Mitoxantrone
(MTO)
is
an
anthraquinone
antitumor
drug
with
potent
therapeutic
benefits.
However,
its
clinical
application
restricted
by
the
severe
side
effects
stemming
from
poor
tumor
selectivity.
In
this
study,
MTO
and
cholesterol
(CLS)
were
conjugated
via
a
tumor-selective
disulfide
bond
to
obtain
MTO-SS-CLS
prodrug.
Interestingly,
could
self-assemble
into
uniform
nanoassemblies,
addition
of
DSPE-PEG2K
significantly
improved
self-assembly
behavior
stability.
Moreover,
compared
solutions,
bond-bridged
nanoassemblies
exhibited
heightened
selectivity
pharmacokinetic
properties.
addition,
prodrug
tolerated
dose
safety
without
compromising
effect.
This
research
enriches
pharmaceutical
paves
way
for
extensive
application.
Theranostics,
Journal Year:
2021,
Volume and Issue:
11(16), P. 7896 - 7910
Published: Jan. 1, 2021
Rationale:
Small-molecule
prodrug
nanoassembly
is
emerging
as
an
efficient
platform
for
chemotherapy.The
self-assembly
stability
plays
a
vital
role
on
the
drug
delivery
efficiency
of
nanoassembly.It
reported
that
fluoroalkylation
could
improve
amphiphilic
polymers
by
utilizing
unique
fluorination
effect.But
application
small-molecule
has
never
been
reported.Methods:
Here,
fluoro-modified
was
developed
conjugating
paclitaxel
with
perfluorooctanol
(F8-SS-PTX),
and
paclitaxel-octanol
(C8-SS-PTX)
used
control.The
fluoro-mediated
mechanisms
were
illustrated
using
molecular
dynamics
simulation.In
addition,
impacts
pharmacy
characters,
in
vivo
fate
antitumor
effect
investigated
details.Results:
Fluoroalkylation
significantly
improved
F8-SS-PTX
NPs
both
vitro
vivo,
which
be
attributed
to
hydrophobic
force
halogen
bonds.The
AUC0-24h
tumor
accumulation
6-fold
2-fold
higher
than
C8-SS-PTX
NPs,
respectively.As
result,
exhibited
much
better
Abraxane.Conclusion:
stability,
fate,
efficacy
nanoassemblies,
effective
strategy
rational
design
advanced
nanomedicines.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
14(45), P. 51200 - 51211
Published: Nov. 3, 2022
Prodrug-based
self-assembled
nanoparticles
combined
with
the
merits
of
nanotechnology
and
prodrugs
strategies
have
gradually
become
a
research
trending
topic
in
field
drug
delivery.
These
usually
consist
parent
drugs,
connecting
bonds,
modifying
chains.
The
influences
bonds
chains
on
pharmaceutical
characteristics,
vivo
delivery
fate,
antitumor
activity
prodrug
nanoassemblies
remain
elusive.
Herein,
three
docetaxel
(DTX)
were
designed
using
sulfur
(thioether
bond
or
disulfide
bond)
as
fatty
alcohols
(straight
chain
branched
chain)
Interestingly,
difference
between
deeply
influenced
colloidal
stability,
redox
responsive
release,
cytotoxicity,
pharmacokinetic
properties,
tumor
accumulation,
effect
nanoassemblies.
DTX
conjugated
via
(HUA-SS-DTX)
significantly
improved
efficiency
reduced
systematic
toxicity.
Our
study
elaborates
vital
role
rational
design
