Redefining cancer photodynamic therapy with gold nanoparticles

Photochemistry and Photobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Despite advancements made in treatment options, cancer continues to be one of the leading causes death worldwide. Photodynamic therapy (PDT) has gained attention as a minimally invasive and highly selective option for cancer. However, challenges due hydrophobicity photosensitizers their poor tumor selectivity have limited use therapy. Recent developments nanotechnology, particularly gold nanoparticles (AuNPs), help overcome these challenges. AuNPs provide stable biocompatible platform deliver photosensitizers, improving solubility, stability, ability target tumors while reducing side effects. Functionalized take advantage mechanisms like enhanced permeability retention (EPR) effect active targeting, reactive oxygen species (ROS) production overall therapeutic efficacy. This review explores innovations AuNP-based PDT systems, including ligand-functionalized nanoparticles, bioresponsive coatings, theranostic approaches that combine imaging with By delving into important aspects synthesis, characterization, functionalization, we show how improve delivery performance photosensitizers. For instance, systems functionalized prostate-specific membrane antigen (PSMA) shown increased precision efficacy vivo. These are paving way more targeted safer treatments, establishing promising approach developing effective oncological therapies greater fewer

Language: Английский

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NIR-II upconversion nanomaterials for biomedical applications

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

This review provides a comprehensive overview of recent biomedical applications upconversion nanomaterials specifically within the near-infrared two-region (NIR-II) window (1000–1700 nm).

Language: Английский

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Tumor‐Resident Intracellular Bacteria Scavenger Activated In Situ Vaccines for Potent Cancer Photoimmunotherapy

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract In situ tumor vaccines, which utilize antigens generated during treatment to stimulate a cancer patient's immune system, has become potential field in immunotherapy. However, due the immunosuppressive microenvironment (ITME), generation of is always mild and not sufficient. Tumor‐resident intracellular bacteria have been identified as complete component contribute creating ITME. Herein, tumor‐resident scavenger designed induce enhanced antitumor photoimmunotherapy‐driven vaccines for treating hypoxic tumors. This developed by integrating photosensitizer CyI antibiotics Doxycycline (Doxy) into thermal‐sensitive tumor‐derived exosomes fused liposomes (ECDL). vitro vivo results showed that ECDL could homologous target cells restrict respiration mitochondrial reduce hypoxia, thus providing continuous oxygen eliminate both bacteria, ablating primary inhibiting metastasis recurrence. Moreover, eliminating neutralizes ITME triggers production bacterial‐related neoantigens, further strength study provided versatile effective are promising local, abscopal, metastatic treatment.

Language: Английский

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Oxygen Tension Regulating Nanoformulation for the Improved Photodynamic Therapy of Hypoxic Tumors

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101587 - 101587

Published: Feb. 19, 2025

Language: Английский

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Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 533, P. 216540 - 216540

Published: Feb. 27, 2025

Language: Английский

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