Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease

Metabolism, Journal Year: 2024, Volume and Issue: 157, P. 155953 - 155953

Published: June 15, 2024

Language: Английский

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A proton pump inhibitor-programmed ROS generator enhances the synergistic efficacy of chemo-/chemodynamic therapy with reduced renal injury

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159201 - 159201

Published: Jan. 1, 2025

Language: Английский

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Innovative fish peptide-loaded chitosomes: Advancing bioactive delivery through comprehensive in vitro and in vivo assessments

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100947 - 100947

Published: March 1, 2025

Language: Английский

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Targeting cell death mechanisms: the potential of autophagy and ferroptosis in hepatocellular carcinoma therapy

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 9, 2024

Ferroptosis is a type of cell death that plays remarkable role in the growth and advancement malignancies including hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) have considerable impact on HCC by functioning as either oncogenes or suppressors. Recent research has demonstrated non-coding ability to control ferroptosis cells, hence impacting tumors resistance these cells drugs. Autophagy mechanism conserved throughout evolution maintaining balance body under normal settings. Nevertheless, occurrence dysregulation autophagy evident progression various human disorders, specifically cancer. dual roles cancer, potentially influencing both survival death. prevalent kind liver genetic mutations changes molecular pathways might worsen its advancement. The subject debate, it capacity repress promote tumor growth. activation can apoptosis, proliferation glucose metabolism, facilitate spread through EMT. Inhibiting hinder enhance respond treatment. regulated several signaling pathways, such STAT3, Wnt, miRNAs, lncRNAs, circRNAs. Utilizing anticancer drugs target may advantageous implications for efficacy cancer

Language: Английский

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Mechanism of Self-Assembled Celastrol-Erianin Nanomedicine for treatment of breast cancer

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 155709 - 155709

Published: Sept. 1, 2024

Language: Английский

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Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156417 - 156417

Published: Jan. 1, 2025

Language: Английский

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SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114165 - 114165

Published: Jan. 27, 2025

Language: Английский

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Targeting Metabolic Diseases with Celastrol: A Comprehensive Review of Anti-Inflammatory Mechanisms and Therapeutic Potential

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119560 - 119560

Published: Feb. 1, 2025

Language: Английский

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Construction of dual-targeted liposomes loaded with celastrol and their application in treating intrahepatic cholangiocarcinoma

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101581 - 101581

Published: Feb. 27, 2025

Intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor with limited treatment options. Celastrol (Cela) shows potential for ICC, but its clinical use hindered by poor water solubility and toxic side effects. To address these challenges enhance anti-tumor efficacy, we developed hyaluronic acid (HA)-coated triphenylphosphine complex-modified liposomes (HCTL) accurate delivery of Cela to cell mitochondria.HCTL enhances Cela's demonstrates high rate encapsulation, stability, sustained drug release behavior. Moreover, HCTL exhibits outstanding anti-ICC efficacy efficiently inducing apoptosis in ICC cells via the mitochondrial pathway due precise targeting capabilities. In an in-situ mouse model activated hydrodynamic transfection AKT Yap, downregulates tumor-associated proliferative indices, attenuates severity liver injury modulates microenvironment. Importantly, overcomes systemic toxicity associated Cela. sum up, potentially effective system treatment.

Language: Английский

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Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses challenge in transitioning CEL from traditional remedy to modern pharmaceutical agent. Recently, emerging discovery approaches products have broadened extensive avenues for uncovering comprehensive and promoting its drug development. Herein, diverse strategies are overviewed pharmacological toxicological studies CEL, including chemical proteomics, protein microarray, degradation‐based profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based screening, multi‐omics analysis, hypothesis‐driven confirmation. Dozens targets been identified, which significantly suggests that functions as multi‐target Further interaction analysis frequency collected reveal PRDXs, HMGB1, HSP90, STAT3, PKM2 may serve key CEL. Additionally, this review highlights positive role facilitating CEL‐based combination therapy delivery, essential further advancing clinical applications Efforts identification not only aid unraveling scientific underpinnings multiple effects but also offer crucial insights development drugs.

Language: Английский

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