Extracellular Vesicles in Asthma: Intercellular Cross-Talk in TH2 Inflammation

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 542 - 542

Published: April 3, 2025

Asthma is a complex, multifactorial inflammatory disorder of the airways, characterized by recurrent symptoms and variable airflow obstruction. So far, two main asthma endotypes have been identified, type 2 (T2)-high or T2-low, based on underlying immunological mechanisms. Recently, extracellular vesicles (EVs), particularly exosomes, gained increasing attention due to their pivotal role in intercellular communication distal signaling modulation. In context pathobiology, an amount experimental evidence suggests that EVs secreted eosinophils, mast cells, dendritic T neutrophils, macrophages, epithelial cells contribute disease This review explores profiling molecular signatures T2-high T2-low asthma, offering novel perspectives mechanisms potential therapeutic targets.

Language: Английский

Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 972 - 984

Published: Nov. 6, 2024

Language: Английский