A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds DOI Creative Commons

Saedah Dereiah,

Muhammad Usman Ghori, Barbara R. Conway

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 27 - 27

Published: Dec. 27, 2024

Background/Objectives: Spironolactone (SP), an aldosterone inhibitor widely used to treat androgen-dependent disorders such as acne, hirsutism, and alopecia, has demonstrated therapeutic potential in both oral topical formulations. However, SP's low solubility poor bioavailability conventional formulations have driven the development of novel nanocarriers enhance its efficacy. This review systematically examines recent advancements SP-loaded nanocarriers, including lipid nanoparticles (LNPs), vesicular (VNPs), polymeric (PNPs), nanofibers (NFs). Methods: A search strategy was developed, relevant literature searched using databases Scopus, PubMed, Google Scholar. The process, screening, inclusion, exclusion criteria, adhered Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Results: comprehensive analysis 13 eligible research articles, corresponding 15 studies, highlights key aspects encapsulation efficiency, stability, particle size, vitro vivo Six studies focused on solid (SLNs) nanostructured carriers (NLCs), which were found improve skin permeation. Another six investigated ethosomes niosomes, demonstrating superior targeting penetration capabilities. Two (PNPs) showed effectiveness delivering SP hair follicles treatment alopecia acne. Additionally, one study indicated significant rosacea therapy. Conclusions: nanocarrier systems represent promising targeted further clinical are required optimize their safety, efficacy, delivery mechanisms.

Language: Английский

Physicochemical characterization and in vivo assessment of novel apixaban-loaded polymeric nano-aggregates DOI
Fakhar ud Din, Hye In Lee, Jung Suk Kim

et al.

Journal of Pharmaceutical Investigation, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Language: Английский

Citations

5
A Quaternary Solid Dispersion System for Improving the Solubility of Olaparib DOI Creative Commons

Tae-Han Yun,

Jeong-Gyun Lee,

Kyu-Ho Bang

et al.

Solids, Journal Year: 2025, Volume and Issue: 6(1), P. 1 - 1

Published: Jan. 2, 2025

To improve the low solubility of poorly water soluble olaparib, in following study, we prepared olaparib-loaded quaternary solid dispersions with hypromellose, Tween 20 or Labrasol, and colloidal silica. The olaparib various types surfactants was evaluated to select most suitable surfactant effectively enhance its solubility, subsequently, were through spray drying. physicochemical properties investigated using scanning electron microscopy, flowability, powder X-ray diffraction, Fourier-transform infrared spectroscopy. particle size smaller more spherical compared drug maintained an amorphous state, exhibited no intermolecular interactions other excipients within dispersion. Additionally, they enhanced flow powder. results subsequent kinetic tests dissolution demonstrated that influenced enhancement release olaparib. Therefore, dispersions, characterized by will be beneficial for oral delivery

Language: Английский

Citations

0
Study on Dispersion Technology of Pigment Powder and Its Interaction Based on Octenyl Succinate Starch and Arabic Gum Complex DOI Open Access
Qin Chen, Xingyu Chen, Shiqing Song

et al.

Starch - Stärke, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

ABSTRACT High concentrations of pigment powders present significant challenges for dispersion stability in cosmetic formulations, the iron oxide yellow paste may lead to flocculation, reducing its stability. This study employed octenyl succinate starch (OSA starch) and Arabic gum (AG) as composite wall materials encapsulate optimize system water‐soluble powders. Transmission electron microscopy (TEM) scanning (SEM) confirmed formation a well‐structured microcapsule, significantly smaller than original particles. Accelerated tests indicated that microcapsule structure enhanced stability, with improved performance observed at higher OAF solution concentrations. The contact angle measurements, which were consistently below 90°, demonstrated wettability hydrophilicity solution, thereby improving skin adhesion. encapsulation using OSA AG underscores potential application natural hydrocolloids modified starches cosmetics industry.

Language: Английский

Citations

0
Development of a Carvedilol-Loaded Solid Self-Nanoemulsifying System with Increased Solubility and Bioavailability Using Mesoporous Silica Nanoparticles DOI Open Access
Ho Won Jang, Nahyun Kim, Sung Giu Jin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1592 - 1592

Published: Feb. 13, 2025

This study developed a solid self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of poorly soluble carvedilol using mesoporous silica nanoparticles (MSNs). The liquid (L-SNEDDS) consisted carvedilol, Peceol, Tween 80, and Labrasol in weight ratio 10:25:50:25. SNEDDS was suspended MSN at various ratios spray-dried produce S-SNEDDS. emulsion size, PDI, solubility, dissolution were evaluated make optimal S-SNEDDS, manufactured L-SNEDDS 1000 500, formed nanoemulsion achieved efficient supersaturation compared alone, which significantly improved solubility (approximately 400 times), 5.7 times 60 min), area under curve (AUC) (21.7 maximum plasma concentration (Cmax) (15.7 times). In addition, physicochemical properties S-SNEDDS by differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR), particle electron microscopy (SEM) images. showed smaller size than crystalline transformed into an amorphous substance, resulting encapsulation MSN. These results suggest that can be novel biocompatible carrier contributing safer more effective system.

Language: Английский

Citations

0
Principle of Tibetan medicine fluoritum processing by vinegar based on the change of microstructure and chemical composition DOI Creative Commons

Yuzhou Zhuo,

Chang Lin,

Jing Hu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Traditional Chinese medicine (TCM) processing is a cultural treasure of the nation. The vinegar-quenched method mineral an important part traditional theory. Fluoritum commonly used clinical drug in medicine. Its microstructure and chemical composition will change after vinegar quenching, which reduce its toxicity enhance efficacy. However, study changes during quenching insufficient. purpose our to compare differences fluoritum processed products from aspects microstructure, content main trace elements, organic elements. carbon nitrogen elements were observed by thermal field emission scanning, energy spectrum, element analyzer, X-ray fluorescence spectrometer inductively coupled plasma mass spectrometer. results showed that particles quenched water flying product became more finer uniform than other (RSD = 18.9%). contents are 0.185% 0.028%, their increased nearly 4 5 times raw product, respectively. There was no significant CaF2 different 1.61%), but iron has doubled. show very 230%). whose significantly Li, V, Zn, Ga, Cr 80%,RSD 84.2%,Zn never been detected 11.3 μg.g-1, RSD 62.3%, 51.3%). with decreased Tl, W 25.4%, 79.5%). can be listed as best for because it make smaller uniform, increase matter remove toxic harmful metal decrease grain size, carbon, U may reasons enhancement efficiency reduction processing.

Language: Английский

Citations

0
Enhancing Bioavailability Of Water-Soluble Drugs through Precision Electrostatic Spraying DOI Creative Commons

Nisha D Barole,

Sunil N. Thitame,

Ashwini Aher

et al.

Journal of Pharmacy And Bioallied Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

A BSTRACT The problem of the bioavailability water-soluble drugs can be staggering in formulation when drug dissolves readily body fluids. Electrostatic spraying, a sophisticated particle engineering technology, has been identified as one most potential methods managing size these to improve their bioavailability. In this review, author discusses principles and mechanisms that are fundamental electrostatic spraying and, more importantly, possibility adjusting dimensions particles so important for dissolution, absorption, Due nanoscale processing drugs, it is achievable extend time small intestine, increase absorption by biological membranes, maintain stable release characteristics. This article will critically discuss parameters affecting formation during solvents used, spray parameters, environmental etc. Examples case studies experimental works validate use technique improvement presented. possible limitations structure, issues scaling up, prospects refining future also discussed. present analysis aims offer comprehensive understanding achieving barriers advance domains delivery systems.

Language: Английский

Citations

0
Molecular Mechanisms for Stabilizing Biologics in the Solid State DOI Creative Commons
Jing Ling, Yong Du, W. Peter Wuelfing

et al.

Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
A Systematic Review of Spironolactone Nano-Formulations for Topical Treatment of Skin Hyperandrogenic Disorders and Chronic Wounds DOI Creative Commons

Saedah Dereiah,

Muhammad Usman Ghori, Barbara R. Conway

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 27 - 27

Published: Dec. 27, 2024

Background/Objectives: Spironolactone (SP), an aldosterone inhibitor widely used to treat androgen-dependent disorders such as acne, hirsutism, and alopecia, has demonstrated therapeutic potential in both oral topical formulations. However, SP's low solubility poor bioavailability conventional formulations have driven the development of novel nanocarriers enhance its efficacy. This review systematically examines recent advancements SP-loaded nanocarriers, including lipid nanoparticles (LNPs), vesicular (VNPs), polymeric (PNPs), nanofibers (NFs). Methods: A search strategy was developed, relevant literature searched using databases Scopus, PubMed, Google Scholar. The process, screening, inclusion, exclusion criteria, adhered Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. Results: comprehensive analysis 13 eligible research articles, corresponding 15 studies, highlights key aspects encapsulation efficiency, stability, particle size, vitro vivo Six studies focused on solid (SLNs) nanostructured carriers (NLCs), which were found improve skin permeation. Another six investigated ethosomes niosomes, demonstrating superior targeting penetration capabilities. Two (PNPs) showed effectiveness delivering SP hair follicles treatment alopecia acne. Additionally, one study indicated significant rosacea therapy. Conclusions: nanocarrier systems represent promising targeted further clinical are required optimize their safety, efficacy, delivery mechanisms.

Language: Английский

Citations

0