Efficacy and safety of mesenchymal stem cell therapy in acute on chronic liver failure: a systematic review and meta-analysis of randomized controlled clinical trials

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 20, 2025

Acute-on-chronic liver failure has become a serious global health burden, which is characterized by an acute deterioration of function, rapidly evolving organ failure, and high short-term mortality in patients with chronic disease. The pathogenesis includes extensive hepatic necrosis, related to intense systemic inflammation subsequently causes the inflammatory cytokine storm, resulting portal hypertension, dysfunction, failure. Mesenchymal stem cells can function as seed remodel repair damaged tissues, thus showing potential therapeutic alternatives for However, standard treatment protocols mesenchymal acute-on-chronic have not been established. We conducted detailed search from PubMed/Medline, Web Science, EMBASE, Cochrane Library find randomized controlled trials published before October 23, 2021. formulated criteria literature screening according PICOS principle (Population, Intervention, Comparison, Outcome, Study design). Subsequently, bias risk assessment tool was used assess quality all enrolled studies. Finally, outcome measurements including model end-stage disease score, albumin, total bilirubin, coagulation aminotransferase were extracted statistical analysis. A 7 clinical included. results studies indicated that who received inoculation showed decreased MELD score 4 weeks 24 weeks, compared counterparts conventional treatment. Reciprocally, improved ALB levels weeks. For secondary indicators, significantly reduced INR ALT levels, control group. Our no significant differences incidence adverse reactions or events monitored after inoculation. This meta-analysis cell infusion effective safe Without increasing events, MSC decrease increase large-cohort longer follow-up periods are required further confirm our conclusions.

Language: Английский

From Critical Care to Transplant: Enhancing Outcomes in Acute-on-Chronic Liver Failure

Current Hepatology Reports, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 6, 2025

Language: Английский

Hepatitis B Virus‐Associated Liver Carcinoma: The Role of Iron Metabolism and Its Modulation

Journal of Viral Hepatitis, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

ABSTRACT Hepatitis B virus (HBV) infection is a significant contributor to the development of hepatocellular carcinoma (HCC), leading cause cancer‐related mortality worldwide. Iron, central co‐factor in various metabolic pathways, plays an essential role liver function, but its dysregulation can lead severe health consequences. Accumulation iron within hepatic cells over time linked increased injury and strongly associated with sensitive exposure range conditions, including cirrhosis, fibrosis ultimately, HCC. This review explores intricate interplay between metabolism HCC context HBV infection. Hepatic overload arise from disruptions homeostasis, causing necrosis, inflammation, fibrosis, ultimately culminating carcinogenesis. Moreover, alterations serum components HBV‐related scenarios have been observed impact persistence Notably, progression HBV‐associated damage exhibits distinct characteristics at stages disease. In addition elucidating complex relationship infection, this also investigates prognostic implications systemic levels for Furthermore, it aims provide comprehensive understanding HCC, extending discussion hepatitis C (HCV) By shedding light on these multifaceted connections, contribute our pathogenesis potentially identify novel therapeutic avenues intervention.

Language: Английский