Cell signaling in Ehrlichia infection and cancer: Parallels in pathogenesis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 14, 2025

Ehrlichia chaffeensis ( E. ) has recently emerged as an intracellular bacterial pathogen with sophisticated survival mechanisms that include repurposing evolutionarily conserved eukaryotic cell signaling pathways for immune evasion. exploits four major developmental (Wnt, Notch, Hedgehog, and Hippo) using s hort li near m otif (SLiM) ligand mimicry to initiate cascades. Dysregulation of these leading unchecked is implicated in various diseases, most notably cancer. Wnt, Hedgehog Hippo inhibit apoptosis co-opt other cellular functions promote infection. This review will explore the exploited during infection new discoveries have illuminated this interesting example convergence cancer biology.

Language: Английский

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Targeting the Hippo pathway in cancer: kidney toxicity as a class effect of TEAD inhibitors?

Trends in cancer, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Signaling Pathways in Clear Cell Renal Cell Carcinoma and Candidate Drugs Unveiled through Transcriptomic Network Analysis of Hub Genes

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8768 - 8768

Published: Sept. 28, 2024

Clear cell renal carcinoma (ccRCC) is a type of kidney cancer. It advances quickly and often metastasizes, making the prognosis for patients challenging. This study used weighted gene co-expression network analysis (WGCNA) to expression data different stages ccRCC obtained in GEO database. The identified three significant highly preserved modules across datasets: GSE53757, GSE22541, GSE66272, GSE73731. Functional annotation pathway enrichment using DAVID revealed inflammatory pathways (e.g., NF-kB, Hippo, HIF-1 pathways) that may drive development progression. also introduced involvement viral infections associated with disease metabolic reprogramming ccRCC. A drug repurposing was conducted identify potential candidates upregulated downregulated hub genes. top are ziprasidone (dopamine serotonin receptor antagonist) fentiazac (cyclooxygenase inhibitor). Other were obtained, such as phosphodiesterase/DNA methyltransferase/ATM kinase inhibitors, acetylcholine antagonists, NAD precursors. Overall, study’s findings suggest identifying several genes signaling related uncover new targets, biomarkers, even drugs can be repurposed, which help develop effective treatments disease.

Language: Английский

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Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 117181 - 117181

Published: Nov. 1, 2024

Language: Английский

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