The Constrained Disorder Principle: Beyond Biological Allostasis DOI Creative Commons

Ofek Adar,

Josef Daniel Shakargy, Yaron Ilan

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 339 - 339

Published: March 25, 2025

The constrained disorder principle (CDP) defines complex biological systems based on inherent variability. Allostasis refers to the physiological processes that help maintain stability in response changing environmental demands. Allostatic load describes cumulative wear and tear body resulting from prolonged exposure stress, it has been suggested mediate relationship between stress disease. This study presents concepts of CDP allostasis while discussing their similarities differences. We reviewed current literature potential benefits introducing controlled doses noise into interventions, which may enhance effectiveness therapies. paper highlights promising role variability provided by a CDP-based second-generation artificial intelligence system improving health outcomes.

Language: Английский

Measuring polar bear health using allostatic load DOI Creative Commons
Sarah J. Teman, Todd C. Atwood, Sarah J. Converse

et al.

Conservation Physiology, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

The southern Beaufort Sea polar bear sub-population (Ursus maritimus) has been adversely affected by climate change and loss of sea ice habitat. Even though the is likely decreasing, it remains difficult to link individual health physiological effects. We developed an index allostatic load, which represents potential dysregulation. load included blood- hair-based analytes measured in physically captured bears spring. examined relation body condition, age, terrestrial habitat use and, over time, for demographic groups. Overall, had no relationship with condition. However, was higher adult females without cubs that used habitats prior year, indicating dysregulation land use. Allostatic declined age cubs. Sub-adult males demonstrated decreased time. Our study one first attempts develop a scoring system free-ranging bears, our findings highlight complexity using as wild species. Establishing links between population dynamics important advancing conservation efforts.

Language: Английский

Citations

0
Cerebrovascular Health Among Sex- and Gender-Diverse People DOI

Z. Paige L'Erario,

Alice Catalano, Fawaz Al‐Mufti

et al.

Neurology Clinical Practice, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 13, 2025

Sex and gender diversity includes people who are intersex, transgender, nonbinary. Americans identifying as sex diverse (SGD) in increasing numbers. Although data limited on the diagnosis management of stroke SGD communities, current literature suggests that there may be unique health needs among these marginalized populations. Health disparities community-specific stressors influence frequency traditional cerebrovascular disease risk factors people. In addition, transgender gender-diverse have higher rates atypical factors, such sexually transmitted infections an increased mental burden. The adverse effects some gender-affirming therapies can increase stroke, particularly transfeminine use long-term estrogen part their medical transition. Decisions to discontinue hormonal therapy after should weighed against psychological risks doing so. commonly prescribed medications for prevention could interact with hormone therapies. Neurologists collaborate primary care providers endocrinologists screen manage secondary stroke. Limited evidence intersex at disease, those congenital adrenal hyperplasia (CAH). People diagnosed CAH including treatment stress-dose corticosteroids or polycythemia due hyperandrogenism. Creating affirming environments knowledge communities lead improved equitable patients by community trust incorporating best practices clinical research settings. exist presentations how is experienced treated people, multiple identities, presenting acute requiring prevention.

Language: Английский

Citations

0
Association of allostatic load measured by allostatic load index on physical performance and psychological responses during arduous military training DOI Creative Commons
Evan D. Feigel, Kristen J. Koltun, Mita Lovalekar

et al.

Physiological Reports, Journal Year: 2025, Volume and Issue: 13(6)

Published: March 1, 2025

Abstract Military personnel experience decrements in physical fitness and psychological well‐being during training that may be attributed to allostatic load. This investigation examined the association between load measured by index (ALI) performance responses undergoing a 10‐week course. Thirty‐one participants (14 women) provided biochemical, questionnaire (perceived stress appraisal (PSS), sleep difficulty (SD), resilience (CD‐RISC‐25), Physical Fitness Test (PFT; three‐mile run [3MR], pullups, Run‐Row PFT score, Push‐Pull Crunches‐Plank total score)) data before after training. ALI (0–8) was calculated using biomarker components from neuroendocrine, autonomic, immune systems. Simple linear regression analysis assessed change (Δ) responses. Backward stepwise identified associated with ( α = 0.05). In men, ΔALI Δpullups β −0.88, p 0.015), Δpush‐pull score −2.87, 0.013), Δtotal −3.48, 0.007), ΔSD −0.56, 0.046) explaining relationships. women, −1.25, < 0.001) ΔCD‐RISC‐25 2.65, 0.025) no component Increased is worsened men improved outcomes highlighting potential sex‐specific increased

Language: Английский

Citations

0
Measuring the Interrelationships Between Cognitive Performance, Race/Ethnicity, Discrimination, Health Behaviors, and Physiological Dysregulation: A Path Analysis of the Multi-Ethnic Study of Atherosclerosis DOI
Sarah Forrester, Joseph J. Gallo, Jeannie‐Marie Leoutsakos

et al.

Journal of Aging and Health, Journal Year: 2025, Volume and Issue: 37(3-4_suppl)

Published: March 1, 2025

Objective The objective of this study was to examine the interrelationships between cognitive performance, race/ethnicity, discrimination, health behaviors, and physiological dysregulation. Methods We used data from Multi-Ethnic Study Atherosclerosis (MESA) ( N = 1667). path analyses association dysregulation, performance using Cognitive Ability Screening Instrument (CASI) at Exam 5 (2010-12) 6 (2016-18). examined relationship discrimination 1 (2000-02) dysregulation 5. overall ethnoracial-stratified analysis. All models were adjusted for age, sex, site, depression, stress, socioeconomic status, APOE -e4. Results Physiological associated with worse in full sample among White ethnoracial subgroup. Everyday better Black participants. Discussion Associations vary should be longitudinally.

Language: Английский

Citations

0
The Constrained Disorder Principle: Beyond Biological Allostasis DOI Creative Commons

Ofek Adar,

Josef Daniel Shakargy, Yaron Ilan

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 339 - 339

Published: March 25, 2025

The constrained disorder principle (CDP) defines complex biological systems based on inherent variability. Allostasis refers to the physiological processes that help maintain stability in response changing environmental demands. Allostatic load describes cumulative wear and tear body resulting from prolonged exposure stress, it has been suggested mediate relationship between stress disease. This study presents concepts of CDP allostasis while discussing their similarities differences. We reviewed current literature potential benefits introducing controlled doses noise into interventions, which may enhance effectiveness therapies. paper highlights promising role variability provided by a CDP-based second-generation artificial intelligence system improving health outcomes.

Language: Английский

Citations

0