Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice DOI Creative Commons
Chunyan Yao, Zhiyuan Wang, Huiyong Jiang

et al.

Scientific Reports, Journal Year: 2021, Volume and Issue: 11(1)

Published: July 1, 2021

Abstract Ganoderma lucidum is a medicinal mushroom used in traditional Chinese medicine with putative tranquilizing effects. However, the component of G. that promotes sleep has not been clearly identified. Here, effect and mechanism acidic part alcohol extract mycelia (GLAA) on were studied mice. Administration 25, 50 100 mg/kg GLAA for 28 days promoted pentobarbital-treated mice by shortening latency prolonging sleeping time. administration increased levels sleep-promoting neurotransmitter 5-hydroxytryptamine Tph2, Iptr3 Gng13 transcripts sleep-regulating serotonergic synapse pathway hypothalamus during this process. Moreover, reduced lipopolysaccharide raised peptidoglycan serum. GLAA-enriched gut bacteria metabolites, including Bifidobacterium , animalis indole-3-carboxylic acid acetylphosphate negatively correlated positively time concentration. Both promotion altered faecal metabolites behaviours disappeared after microbiota depletion antibiotics. Our results showed through microbiota-dependent serotonin-associated

Language: Английский

The interplay between sleep and gut microbiota DOI
Mengqi Han, Shiying Yuan, Jiancheng Zhang

et al.

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 180, P. 131 - 146

Published: Jan. 13, 2022

Language: Английский

Citations

80
Circadian rhythm regulates the function of immune cells and participates in the development of tumors DOI Creative Commons

Yuen Zeng,

Zichan Guo, Mengqi Wu

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 27, 2024

Abstract Circadian rhythms are present in almost all cells and play a crucial role regulating various biological processes. Maintaining stable circadian rhythm is essential for overall health. Disruption of this can alter the expression clock genes cancer-related genes, affect many metabolic pathways factors, thereby affecting function immune system contributing to occurrence progression tumors. This paper aims elucidate regulatory effects BMAL1, other on cells, reveal molecular mechanism rhythm’s involvement tumor its microenvironment regulation. A deeper understanding has potential provide new strategies treatment cancer immune-related diseases.

Language: Английский

Citations

37
Microbes Saving Lives and Reducing Suffering DOI Creative Commons
Kenneth N. Timmis, Zeynep Ceren Karahan, Juan L. Ramos

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Language: Английский

Citations

4
Sedentary behaviour and sleep quality DOI Creative Commons
Mohammad Javad Koohsari, Akitomo Yasunaga, Gavin R. McCormack

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 20, 2023

Abstract High-quality sleep is an important factor in sustaining health and improving well-being. Previous evidence has demonstrated the positive associations between increased physical activity reduced sedentary behaviour (SB) with quality. The substitutional relationships SB, light-intensity (LPA), moderate-to-vigorous (MVPA) need to be considered when examining how a particular may impact No studies, our knowledge, have explored these middle-aged adulthood. Using isotemporal substitution approach, this study examined of replacing time on quality measures sample adults Japan. Data from 683 aged 40–64 living Japan were used. average daily spent LPA, MVPA was objectively assessed by accelerometers. Two self-reported obtained using questionnaires, including rest Multivariable linear regression models used assess stratified gender. We found that each 60 min unit SB or LPA replaced favourably associated among women ( β = 0.16, 95% CI 0.07, 0.28, p < 0.001; 0.18, 0.32, 0.05, respectively). There no significant men across all three models. These findings indicate higher association women.

Language: Английский

Citations

35
Efficacy of non-pharmacological interventions on improving sleep quality in depressed patients: A systematic review and network meta-analysis DOI

Aiwen Sun,

Xia Wu

Journal of Psychosomatic Research, Journal Year: 2023, Volume and Issue: 172, P. 111435 - 111435

Published: July 9, 2023

Language: Английский

Citations

29
Technologies for sleep monitoring at home: wearables and nearables DOI
Heenam Yoon, Sang Ho Choi

Biomedical Engineering Letters, Journal Year: 2023, Volume and Issue: 13(3), P. 313 - 327

Published: July 7, 2023

Language: Английский

Citations

26
Sleep‐Related Breathing Disorders and Lower Urinary Tract Dysfunction in Children and Adolescents: A Scoping Review DOI Creative Commons
Maayke van Galen,

Bibi Huskens,

Bahar Tekin Tak

et al.

Neurourology and Urodynamics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Sleep disordered breathing (SDB), lower urinary tract dysfunction (LUTD), and enuresis (NE) are common in children adolescents have serious consequences, especially on social emotional development. Even though much is known about the association between SDB NE among adults, number of articles limited. Therefore, aim present scoping review was to map out current knowledge LUTD adolescents.

Language: Английский

Citations

1
Sleep disturbances and their correlation with memory impairment in patients with Alzheimer's disease and amnestic mild cognitive impairment DOI Creative Commons

Linyang Cui,

Yahui Wan,

Yunyao Lu

et al.

Journal of Alzheimer s Disease Reports, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Episodic memory impairment is the core clinical feature of patients with typical Alzheimer's disease (AD) at an early stage. Since sleep plays a very important role in consolidation, relationship between and disorders AD worthy investigation. To investigate disturbances their correlations amnestic mild cognitive (aMCI). Forty-three AD, 43 aMCI, cognitively unimpaired controls (CUCs) were recruited subjected to assessment via Hopkins Verbal Learning Test-Revised objective evaluation polysomnography (PSG). The total time percentages nonrapid eye movement (NREM) stage 3 (N3) rapid (REM) lower, while NREM 2 (N2) greater aMCI groups than CUC group (all p < 0.01). Compared group, also presented longer latency higher 1 (N1) percentage, apnea-hypopnea index (AHI), periodic limb movements during (PLMSI), arousal (AI). Both learning scores delayed recall positively correlated N3 percentage negatively AHI PLMSI Recognition AI Our results suggest that disturbance disability patients. PSG useful for screening monitoring AD.

Language: Английский

Citations

1
S4Sleep: Elucidating the design space of deep-learning-based sleep stage classification models DOI Creative Commons

Tiezhi Wang,

Nils Strodthoff

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 187, P. 109735 - 109735

Published: Feb. 3, 2025

Language: Английский

Citations

1
Medicinal Plants for Insomnia Related to Anxiety: An Updated Review DOI Open Access

Silvia Borrás,

Isabel Martínez‐Solís,

José Luis Rı́os

et al.

Planta Medica, Journal Year: 2021, Volume and Issue: 87(10/11), P. 738 - 753

Published: June 11, 2021

Abstract Sleep disorders are common among the general population and can generate health problems such as insomnia anxiety. In addition to standard drugs psychological interventions, there different complementary plant-based therapies used treat This review aimed find examine most recent research on use of herbal medicines for treating anxiety compiled from clinical trials, well assess safety efficacy these elucidate their possible mechanisms action. The process entailed a search PubMed, Scopus, Cochrane Library databases 2010 2020. terms included “sleep disorder”, “insomnia”, “sedative”, “hypnotic”, “anxiety”, “anxiolytic”, “clinical trial”, combined with “herbs” “medicinal plants”, in individual by both scientific names. updated review, which focuses mainly includes 23 medicinal plants combinations. Essential oils associations have also been reviewed. depends treatment duration, types study subjects, administration route, method. More trials an adequate, standardized design necessary, more preclinical studies continue studying As result our work, we conclude that 3 potential valerian, passionflower, ashwagandha, combination valerian hops passionflower giving best results tests.

Language: Английский

Citations

45