International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(24), P. 13535 - 13535
Published: Dec. 18, 2024
Non-specific
Lipid
Transfer
proteins
(nsLTPs)
are
relevant
allergens
of
several
pollens
and
plant
foods.
Sensitization
to
nsLTPs
is
not
typical
in
our
region.
Still,
it
has
become
an
increasingly
common
cause
IgE-mediated
food
allergies
food-induced
anaphylaxis
Northern
Europe
recent
decades.
No
in-depth
studies
describe
the
prevalence
sensitization
molecular
components
Lithuania.
This
study
aimed
determine
profile
atopic
patients
at
Immunology
Allergy
Department
Kauno
Klinikos
nsLTPs,
using
allergen
component
analysis.
Sixty
Lithuanian
adults
with
symptoms
allergic
rhinitis
and/or
asthma
were
included
into
study.
Specific
immunoglobulin
E
(IgE)
levels
measured
two
vitro
techniques:
extract
Results
showed
that
25%
subjects
sensitized
nsLTP-containing
sources,
mostly
Zea
m
14,
Mal
d
3,
Vit
v
1,
Art
3.
The
median
amount
total
IgE
was
higher
nsLTP-sensitized
than
nsLTP-nonsensitized
patients.
Based
on
Cohen’s
Kappa
McNemar
tests,
results
analysis
tests
do
always
agree,
especially
when
we
sources
containing
nsLTPs.
Molecular
could
be
first
choice
determining
detailed
who
experienced
unknown
origin.
Clinical and Experimental Medicine,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Sept. 26, 2024
In
recent
years,
there
has
been
a
global
increase
in
the
prevalence
of
allergic
diseases,
including
rhinitis,
chronic
rhinosinusitis,
asthma,
atopic
dermatitis,
conjunctivitis,
and
food
allergies.
Since
pathogenic
mechanisms
these
diseases
are
not
yet
fully
understood,
targeted
effective
therapies
lacking.
The
NLRP3
inflammasome,
multiprotein
complex
implicated
various
inflammatory
can
be
activated
by
diverse
stimuli.
It
assembles
into
inflammasome
complexes
through
conformational
changes,
initiating
proteolytic
cleavage
dormant
procaspase-1
active
caspase-1
promoting
maturation
cytokines,
IL-1β
IL-18.
Dysfunction
may
serve
as
key
driver
leading
to
pyroptosis
amplifying
local
response.
As
preliminarily
demonstrated,
specific
vesicle
inhibitors
play
refectory
roles
animal
models
it
is
believed
that
potential
therapeutic
agents
for
diseases.
This
review
highlights
progress
research
on
explores
its
contribution
different
types
identifies
promising
clinical
targets
intervention.
Diseases,
Journal Year:
2024,
Volume and Issue:
12(6), P. 118 - 118
Published: June 3, 2024
According
to
the
definition
provided
by
United
Nations,
“climate
change”
describes
persistent
alterations
in
temperatures
and
weather
trends.
These
may
arise
naturally,
such
as
fluctuations
solar
cycle.
Nonetheless,
since
19th
century,
human
activities
have
emerged
primary
agent
for
climate
change,
primarily
attributed
combustion
of
fossil
fuels
coal,
oil,
gas.
Climate
change
can
potentially
influence
well-being,
agricultural
production,
housing,
safety,
employment
opportunities
all
individuals.
The
immune
system
is
an
important
interface
through
which
global
affects
health.
Extreme
heat,
events
environmental
pollutants
could
impair
both
innate
adaptive
responses,
promoting
inflammation
genomic
instability,
increasing
risk
autoimmune
chronic
inflammatory
diseases.
Moreover,
has
impact
on
soil
gut
microbiome
composition,
further
explain
changes
health
outcomes.
This
narrative
review
aims
explore
disease,
focusing
specifically
its
effects
microbiota.
Understanding
how
these
factors
contribute
development
physical
mental
illness
allow
design
strategies
aimed
at
reducing
negative
pollution
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Abstract
Climate
change
and
urbanization
are
associated
with
reduced
greenness
vegetation
diversity,
depletion
of
biodiversity,
impoverishment
human
microbiota.
These
changes
may
influence
immune
regulation
increase
the
risk
many
chronic
inflammatory
diseases,
such
as
asthma.
This
short
communication
presents
results
a
meta-analysis
association
between
exposure
to
outer
inner
layers
biodiversity
development
The
effect
estimates
for
were
summarized
standardized
mean
difference
or
relative
95%
confidence
interval
applying
Hedges
method
restricted
maximum
likelihood
estimator,
respectively.
Our
existing
evidence
suggests
high
environmental
reduces
asthma,
while
inner-layer
bacterial
Immunological Reviews,
Journal Year:
2025,
Volume and Issue:
331(1)
Published: May 1, 2025
ABSTRACT
Antibodies
play
a
vital
role
in
the
immune
system,
with
distinct
isotypes
having
unique
tropisms
and
performing
specialized
functions.
Of
these
isotypes,
IgE
is
least
abundant
circulation
yet
plays
critical
defense
against
parasitic
infection
allergic
reactions.
also
heavily
N‐linked
glycosylated,
posttranslational
modification
that
influences
receptor
interactions
of
effector
responses.
The
importance
glycosylation
on
IgG
function
well
established,
roles
glycans
are
emerging.
This
review
examines
relationship
between
its
biological
function.
glycosylation,
specifically
oligomannosidic
glycan,
necessary
for
binding
to
high‐affinity
FcεRI
mast
cells
basophils.
Recent
evidence
suggests
terminal
sialic
acid
residues
complex
biantennary
significantly
enhance
IgE's
potential,
sialylation
demonstrating
reduced
capacity
trigger
degranulation
anaphylaxis.
Glycosylation
interaction
low‐affinity
FcεRII/CD23,
affecting
serum
clearance
antigen
presentation.
Beyond
allergy,
this
covers
impacts
autoimmunity,
parasite
defense,
protection
venoms.
Current
therapeutic
approaches
targeting
include
monoclonal
antibodies
like
omalizumab,
emerging
therapeutics
looking
target
systemic
production
mechanisms
covered.
Although
understanding
known,
there
much
uncover
terms
which
may
open
new
avenues
developing
more
precise
interventions
modulate
