In Silico Identification of Peanut Peptides Suitable for Allergy Immunotherapy in HLA-DRB1*03:01-Restricted Patients DOI Creative Commons
Irini Doytchinova, Mariyana Atanasova,

Stanislav Sotirov

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1097 - 1097

Published: Aug. 21, 2024

Peanut allergy, a prevalent and potentially severe condition affecting millions worldwide, has been linked to specific human leukocyte antigens (HLAs), suggesting increased susceptibility. Employing an immunoinformatic strategy, we developed “logo model” based on amino acid frequencies in the peptide binding core used it predict peptides originating from 28 known peanut allergens HLA-DRB1*03:01, one of susceptibility alleles. These hold promise for immunotherapy HLA-DRB1*03:01 carriers, offering reduced allergenicity compared whole proteins. By targeting essential epitopes, can modulate immune responses with minimal risk reactions. This precise approach could induce tolerance fewer adverse effects, presenting safer more effective treatment allergy other allergic conditions.

Language: Английский

Dysbiosis of infant gut microbiota is related to the altered fatty acid composition of human milk from mothers with gestational diabetes mellitus: a prospective cohort study DOI Creative Commons
Kelei Li, Jin Jin,

Zhizuo Liu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 21, 2025

Gestational diabetes mellitus (GDM) is known to be associated with dysbiosis of offspring gut microbiota, but the mechanism remains unclear. The present prospective study explored role human milk fatty acid composition in this association. Mothers GDM and normal controls were recruited at 24–28 gestational weeks. Follow-up was conducted 1–3 days postpartum 1 month collect infant feces. A total 80 mother-infant pairs (40 group 40 group) included study. mothers received guidance on diet exercise not drug therapy. All infants exclusively breastfed. We observed significant differences 8 phyla 13 genera between groups or postpartum. Among these bacteria, time × interaction for 7 (such as Acidobacteriota, Gemmatimonadota, Myxococcota) 9 Sphingomonas, Allorhizobium Neorhizobium Pararhizobium Rhizobium, TM7a), after adjusting confounding factors. Changes differential bacteria negatively correlated changes C18:3n-3 n-3 PUFA levels breast milk. increases over much greater compared group. Our findings indicate that altered one important reason GDM-related microbiota.

Language: Английский

Citations

0
In Silico Identification of Peanut Peptides Suitable for Allergy Immunotherapy in HLA-DRB1*03:01-Restricted Patients DOI Creative Commons
Irini Doytchinova, Mariyana Atanasova,

Stanislav Sotirov

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1097 - 1097

Published: Aug. 21, 2024

Peanut allergy, a prevalent and potentially severe condition affecting millions worldwide, has been linked to specific human leukocyte antigens (HLAs), suggesting increased susceptibility. Employing an immunoinformatic strategy, we developed “logo model” based on amino acid frequencies in the peptide binding core used it predict peptides originating from 28 known peanut allergens HLA-DRB1*03:01, one of susceptibility alleles. These hold promise for immunotherapy HLA-DRB1*03:01 carriers, offering reduced allergenicity compared whole proteins. By targeting essential epitopes, can modulate immune responses with minimal risk reactions. This precise approach could induce tolerance fewer adverse effects, presenting safer more effective treatment allergy other allergic conditions.

Language: Английский

Citations

0