Farm exposure is associated with human breast milk immune profile and microbiome DOI Creative Commons
Mary Hannah Swaney,

Olivia Steidl,

Anastasia Tackett

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

SUMMARY Prenatal and early life farm exposure, breastfeeding, are associated with protection from allergic diseases. We hypothesize that exposure influences the human breast milk microbiome immune proteins. The protein profiles microbial communities of 152 samples were compared among three maternal groups (traditional agrarian, farm, non-farm) in rural Wisconsin to identify signatures status atopic disease. found significant differences between for 23 proteins (p-adj<0.05), diversity (p=2.2E-05), richness (p=8.0e-06). Traditional agrarian had highest levels richness, followed by non-farm milk. Furthermore, Gram-positive bacterial species correlated IL-23 mediated signaling events (p-adj<1.0E-05). These data suggest increased exposures promotes is more microbially-diverse rich immune-associated proteins, ultimately influencing development infant.

Language: Английский

New delivery systems potential for current anti-allergy drugs DOI Creative Commons
Ruoyu Hou, Juehui Zeng,

Heqiang Sun

et al.

Allergy medicine., Journal Year: 2024, Volume and Issue: unknown, P. 100028 - 100028

Published: Dec. 1, 2024

Language: Английский

Citations

1
Management of atopic dermatitis with food allergy DOI
Donald Y.M. Leung

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(3), P. 231 - 232

Published: Aug. 23, 2024

Language: Английский

Citations

0
Farm exposure is associated with human breast milk immune profile and microbiome DOI Creative Commons
Mary Hannah Swaney,

Olivia Steidl,

Anastasia Tackett

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

SUMMARY Prenatal and early life farm exposure, breastfeeding, are associated with protection from allergic diseases. We hypothesize that exposure influences the human breast milk microbiome immune proteins. The protein profiles microbial communities of 152 samples were compared among three maternal groups (traditional agrarian, farm, non-farm) in rural Wisconsin to identify signatures status atopic disease. found significant differences between for 23 proteins (p-adj<0.05), diversity (p=2.2E-05), richness (p=8.0e-06). Traditional agrarian had highest levels richness, followed by non-farm milk. Furthermore, Gram-positive bacterial species correlated IL-23 mediated signaling events (p-adj<1.0E-05). These data suggest increased exposures promotes is more microbially-diverse rich immune-associated proteins, ultimately influencing development infant.

Language: Английский

Citations

0