Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice DOI Creative Commons
Jiaheng Lu, Yanting Huang, Yujing Zhang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Obesity is a chronic metabolic disease, mainly caused by excessive/abnormal fat accumulation, as well accompanied endotoxemia and inflammation. Quercetin, natural flavonoid, may alleviate obesity regulating gut microbiota metabolites, but its exact mechanism for improving unknown. The aim of this study was to investigate the effects quercetin on high-fat diet (HFD)-induced in mice. In particular, we focused regulatory tryptophan metabolite indole-3-propionic acid (IPA). C57BL/6J mice were subjected 20-week HFD feeding regimen with concurrent daily oral administration or IPA. body weight, barrier function, inflammation determined. Gut composition analyzed 16S rRNA sequencing IPA levels measured serum feces. vitro experiments, Caco-2 cells used evaluate fecal dilutions from quercetin-treated tight junction protein expression aryl hydrocarbon receptor (AhR) activation. Our results revealed that supplementation significantly mitigated inflammation, improved disrupted function through actvation AhR/interleukin 22 (IL-22) pathway. treatment increased abundance Lactobacillus. Quercetin intervention feces alleviated enhanced intestinal AhR findings further corroborated cell experiment, which indicated modulation dysregulated change microbial coordinated improvement effect disruption. alleviates restoring induced disorder, elevates level activate AhR/IL-22 pathway, thereby enhancing integrity suppressing

Language: Английский

Antibiotics and Opportunities of Their Alternatives in Pig Production: Mechanisms Through Modulating Intestinal Microbiota on Intestinal Health and Growth DOI Creative Commons
Jung Yeol Sung, Zixiao Deng, Sung Woo Kim

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(3), P. 301 - 301

Published: March 14, 2025

Antibiotics at subtherapeutic levels have been used in pig diets as antimicrobial growth promoters. However, concerns about antibiotic resistance increased the demand for alternatives to these This review paper explores mechanisms through which promoters and their exert effects. Additionally, this systemic also covers how modulation of intestinal microbiota by or affects health and, subsequently, pigs. The effects on microbiota, health, are diverse inconsistent. Therefore, producers should carefully assess alternative is most effective optimizing both profitability status pigs production system.

Language: Английский

Citations

0
Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice DOI Creative Commons
Jiaheng Lu, Yanting Huang, Yujing Zhang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Obesity is a chronic metabolic disease, mainly caused by excessive/abnormal fat accumulation, as well accompanied endotoxemia and inflammation. Quercetin, natural flavonoid, may alleviate obesity regulating gut microbiota metabolites, but its exact mechanism for improving unknown. The aim of this study was to investigate the effects quercetin on high-fat diet (HFD)-induced in mice. In particular, we focused regulatory tryptophan metabolite indole-3-propionic acid (IPA). C57BL/6J mice were subjected 20-week HFD feeding regimen with concurrent daily oral administration or IPA. body weight, barrier function, inflammation determined. Gut composition analyzed 16S rRNA sequencing IPA levels measured serum feces. vitro experiments, Caco-2 cells used evaluate fecal dilutions from quercetin-treated tight junction protein expression aryl hydrocarbon receptor (AhR) activation. Our results revealed that supplementation significantly mitigated inflammation, improved disrupted function through actvation AhR/interleukin 22 (IL-22) pathway. treatment increased abundance Lactobacillus. Quercetin intervention feces alleviated enhanced intestinal AhR findings further corroborated cell experiment, which indicated modulation dysregulated change microbial coordinated improvement effect disruption. alleviates restoring induced disorder, elevates level activate AhR/IL-22 pathway, thereby enhancing integrity suppressing

Language: Английский

Citations

0