Peptide-Based Inhibitors of Protein–Protein Interactions (PPIs): A Case Study on the Interaction Between SARS-CoV-2 Spike Protein and Human Angiotensin-Converting Enzyme 2 (hACE2) DOI Creative Commons
Aizhan Rakhmetullina, Piotr Zielenkiewicz, Norbert Odolczyk

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2361 - 2361

Published: Oct. 16, 2024

Protein-protein interactions (PPIs) are fundamental to many critical biological processes and crucial in mediating essential cellular functions across diverse organisms, including bacteria, parasites, viruses. A notable example is the interaction between SARS-CoV-2 spike (S) protein human angiotensin-converting enzyme 2 (hACE2), which initiates a series of events leading viral replication. Interrupting this offers promising strategy for blocking or significantly reducing infection, highlighting its potential as target anti-SARS-CoV-2 therapies. This review focuses on hACE2 interaction, exemplifying latest advancements peptide-based strategies developing PPI inhibitors. We discuss various approaches creating inhibitors that aiming provide treatments COVID-19.

Language: Английский

In silico exploration of natural xanthone derivatives as potential inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and cellular entry DOI Creative Commons
Vincent A. Obakachi, Vaderament‐A. Nchiozem‐Ngnitedem, Krishna Govender

et al.

Journal of Computer-Aided Molecular Design, Journal Year: 2025, Volume and Issue: 39(1)

Published: Feb. 17, 2025

Language: Английский

Citations

0
Decoding the SARS-CoV-2 Infection Process: Insights into Origin, Spread, and Therapeutic Approaches DOI
Saheem Ahmad,

Ahmed Alafnan,

Ahmed Alobaida

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107328 - 107328

Published: Jan. 1, 2025

Language: Английский

Citations

0
Peptide-Based Inhibitors of Protein–Protein Interactions (PPIs): A Case Study on the Interaction Between SARS-CoV-2 Spike Protein and Human Angiotensin-Converting Enzyme 2 (hACE2) DOI Creative Commons
Aizhan Rakhmetullina, Piotr Zielenkiewicz, Norbert Odolczyk

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2361 - 2361

Published: Oct. 16, 2024

Protein-protein interactions (PPIs) are fundamental to many critical biological processes and crucial in mediating essential cellular functions across diverse organisms, including bacteria, parasites, viruses. A notable example is the interaction between SARS-CoV-2 spike (S) protein human angiotensin-converting enzyme 2 (hACE2), which initiates a series of events leading viral replication. Interrupting this offers promising strategy for blocking or significantly reducing infection, highlighting its potential as target anti-SARS-CoV-2 therapies. This review focuses on hACE2 interaction, exemplifying latest advancements peptide-based strategies developing PPI inhibitors. We discuss various approaches creating inhibitors that aiming provide treatments COVID-19.

Language: Английский

Citations

3