Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis

Preventive Medicine Reports, Journal Year: 2025, Volume and Issue: 50, P. 102968 - 102968

Published: Jan. 9, 2025

Considering that both long and short sleep duration may have an association with nonalcoholic fatty liver disease (NAFLD), in this meta-analysis, we analyzed the dose-response between NAFLD along meta-analyses of differences mean patients healthy controls, linear meta-analysis NAFLD. PubMed (665 articles), Scopus (442 Web Sciences (200 articles) were searched from inception until November 2023. Observational studies included if they assess or compare population. All done humans without restriction on sex, age, language included. The methological quality was assessed by Joanna Briggs Institute (JBI) tools. conducted using STATA. Thirty-one 836,117 participants systematic review. results indicated no significant controls regarding [Mean difference: -7.08, 95 % CI: -20.10, 5.94]. subgroup did not show any groups. versus showed a (OR: 0.8 [95 CI, 0.74-0.91]). do suggest nonlinear relationship (p-value = 0.9). highest category associated lower risk However, observed.

Language: Английский

Circadian Deregulation: Back Facing the Sun Toward Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4294 - 4294

Published: Dec. 12, 2024

Earth’s rotation around its axis has pressured inhabitants to adapt 24 h cycles of day and night. Humans adapted their own circadian rhythms the with a light-aligned awake–sleep cycle. As consequence, metabolism undergoes drastic changes throughout cycle needs plasticity cope opposing conditions in (when there is an increase energy demands food availability), during night prolonged fasting couples cyclic across sleep stages). In last century, human behavior changed dramatically disregard for natural cycles. This misalignment eating schedules strongly modulates homeostasis, favoring development obesity, metabolic syndrome, dysfunction-associated steatotic liver disease (MASLD). review summarizes effects disruption, particular focus on feeding MASLD hepatocellular carcinoma.

Language: Английский

The moderating effect of dietary fiber intake on the association between sleep pattern and liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

Insufficient nocturnal sleep was associated with a higher risk of fibrosis in patients metabolic dysfunction-associated steatotic liver disease (MASLD). Dietary fiber intake may improve the stimulate secretion cytokines, inhibit inflammatory pathway, contribute to regulating disorders and alleviate fibrosis. The associations dietary intake, patterns, remain unclear. study aimed explore between fiber, sleep, fibrosis, as well moderating effect patterns MASLD patients. Using data from National Health Nutrition Examination Survey (NHANES) database spanning 2017 2020, cross-sectional included participants performed assess relationship Weighted univariate multivariate logistic regression models were used examine linear connection pattern, Restricted cubic spline (RCS) method also describe nonlinear relationship. A two-part model estimate threshold effects. further investigated different subgroups. All results presented odds ratios (ORs) 95% confidence intervals (CIs). Totally, 1343 for final analysis. Among them, 207 (15.41%) have did not correlate significantly pattern (Spearman's r = -0.028, P 0.1678). Poor related (OR 3.23, 95%CI: 1.05–9.90), while ≥ 15 gm/day lower 0.51, 0.32–0.83). On association stratified by revealed that poor 15.13, 4.40-52.01) remained increased among individuals < gm/day. No observed moderate supplementation beneficial mitigating similar findings found aged 50 years old, females, those without CVD groups, hypertension, dyslipidemia. Particularly, moderates F4 stage 13.26, 4.08–43.11). affects

Language: Английский