The Effects of Whole Body Vibration Training on Neuromuscular Property in Individuals with Spinocerebellar Ataxia: A Pilot Study

Neurorehabilitation, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Background Spinocerebellar ataxia (SCA) is a neurodegenerative disease causing weakness and balance disorders that affected quality of life. Whole body vibration (WBV) had been reported to facilitate neuromuscular contraction in healthy people athletes. Objective The purpose this study was investigate whether four weeks WBV training can enhance central peripheral muscle strength performances patients with SCA. Methods Thirteen individuals diagnosed SCA were randomly assigned into control groups. Subjects the group received at semi-squatting position for 3 sessions per week; whereas subjects performed same duration. maximum voluntary (MVC), activation level (VA), twitch force, Berg scale (BBS), one-leg standing time evaluated before after training. All could tolerate Results MVC soleus, VA plantar flexors knee extensors, score BBS (p < 0.05) improved .05) only group. Conclusions feasible rehabilitation strategy which improve general origin force performance

Language: Английский

Predictive machine learning and multimodal data to develop highly sensitive, composite biomarkers of disease progression in Friedreich Ataxia

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Friedreich Ataxia (FRDA) is a rare, inherited progressive movement disorder for which there currently no cure. The field urgently requires more sensitive, objective, and clinically relevant biomarkers to enhance the evaluation of treatment efficacy in clinical trials speed up process drug discovery. This study pioneers development relevant, multidomain, fully objective composite disease severity progression, using multimodal neuroimaging background data (i.e., demographic, history, genetics). Data from 31 individuals with FRDA controls longitudinal natural history IMAGE-FRDA, were included. Using an elasticnet predictive machine learning (ML) regression model, we derived weighted combination background, structural MRI, diffusion quantitative susceptibility imaging (QSM) measures that predicted Rating Scale (FARS) high accuracy (R² = 0.79, root mean square error (RMSE) 13.19). also exhibited strong sensitivity progression over two years (Cohen's d 1.12), outperforming FARS score alone (d 0.88). approach was validated Assessment (SARA), demonstrating potential robustness ML-derived composites surpass individual act as complementary or surrogate markers progression. However, further validation, refinement, integration additional modalities will open new opportunities translating these into practice FRDA, well other rare neurodegenerative diseases.

Language: Английский

Goal‐Directed Rehabilitation Versus Standard Care for Individuals with Hereditary Cerebellar Ataxia: A Multicenter, Single‐Blind, Randomized Controlled Superiority Trial

Annals of Neurology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Rehabilitation is thought to reduce ataxia severity in individuals with hereditary cerebellar (HCA). This multicenter, randomized controlled superiority trial aimed examine the efficacy of a 30-week goal-directed rehabilitation program compared 30 weeks standard care on function, ataxia, health-related quality life, and balance an HCA.

Language: Английский