Emerging Promise of Green Synthesized Metallic Nanoparticles for the Management of Neurological Disorders DOI

Zahra Esmaeili Moghaddam,

Samin Hamidi, Maryam Azarfarin

et al.

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 31(5), P. 344 - 359

Published: Oct. 14, 2024

The management of neurological disorders is very challenging due to the presence bloodbrain barrier (BBB) that prevents entry drugs into central nervous system (CNS). advancement metallic nanoparticles (NPs) provides a novel direction for treatment disorders. However, there significant concern regarding toxic effects metal NPs on biological tissues like brain. green synthesis strategy offers superior alternative traditional methods development NPs. Notable and oxide can be produced using various bio-reductants derived from natural sources such as plant tissues, fungi, bacteria, yeast, alga. These agents play double roles they expedite reduction process act capping stabilizing agents. In this paper, we discuss major physical barriers limiting transport therapeutics CNS. Moreover, special focus given unique features synthesized therapeutic purposes in insights provided will guide future research toward better outcomes facilitate innovative treatments

Language: Английский

Metareview: a survey of active matter reviews DOI Creative Commons
Michael te Vrugt, Raphael Wittkowski

The European Physical Journal E, Journal Year: 2025, Volume and Issue: 48(2)

Published: Feb. 1, 2025

In the past years, amount of research on active matter has grown extremely rapidly, a fact that is reflected in particular by existence more than 1000 reviews this topic. Moreover, field become very diverse, ranging from theoretical studies statistical mechanics particles to applied work medical applications microrobots and biological systems artificial swimmers. This makes it difficult get an overview over as whole. Here, we provide such form metareview article surveys existing review articles books matter. Thereby, provides useful starting point for finding literature about specific

Language: Английский

Citations

2

Magnetic–Plasmonic Core–Shell Nanoparticles: Properties, Synthesis and Applications for Cancer Detection and Treatment DOI Creative Commons
Alberto Luis Rodriguez-Nieves, Suprava Shah, Mitchell Lee Taylor

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(4), P. 264 - 264

Published: Feb. 10, 2025

Nanoparticles have been widely used in cancer diagnostics and treatment research due to their unique properties. Magnetic nanoparticles are popular imaging techniques ability alter the magnetization field around them. Plasmonic mainly applied treatments like photothermal therapy convert light into heat. While these among respective fields, magnetic–plasmonic core–shell (MPNPs) gained popularity recent years combined magnetic optical properties from core shell. MPNPs stood out theranostics as a multimodal platform capable of serving contrast agent for imaging, guidable drug carrier, causing cellular ablation through energy conversion. In this review, we summarize different most common synthesis approaches. We particularly discuss applications diagnosis based on mechanisms using particles. Lastly, look current challenges they face clinical future perspectives detection therapy.

Language: Английский

Citations

0

Harnessing Metal Nanoparticles: Revolutionizing Cancer Therapy Through Targeted Drug Delivery and Tumor Microenvironment Modulation DOI
Kiran Dudhat

NANO, Journal Year: 2024, Volume and Issue: 19(10)

Published: May 4, 2024

Cancer remains a significant global health burden, claiming countless lives annually and incurring substantial direct indirect economic costs. Despite advancements in therapeutic modalities, conventional cancer treatments, including chemotherapy, radiotherapy surgery, are often hampered by limitations such as insufficient efficacy, dose-dependent side effects, high costs patient tolerability. This has spurred extensive research into novel approaches for this life-threatening disease. Metal nanoparticles (MNPs) have emerged promising tools therapy due to their unique physicochemical properties spanning the past two decades. Owing size similarity biological molecules, MNPs possess inherent ability penetrate cellular barriers, making them ideal carriers targeted drug delivery. These multifunctional nanoplatforms offer distinct advantages over therapeutics enabling delivery of anticancer agents specific tumor sites, thereby enhancing efficacy minimizing systemic effects. Photodynamic sonodynamic represent particularly strategies that leverage treatment. review delves potential applications modulating microenvironment, paving way exploration vast rapidly evolving field nanomedicine.

Language: Английский

Citations

1

Bioorthogonal Chemistry-Based Prodrug Strategies for Enhanced Biosafety in Tumor Treatments: Current Progress and Challenges DOI
Yongchao Yao, Ying Chen, Chang Chun Zhou

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10818 - 10834

Published: Jan. 1, 2024

Prodrugs, activated at the tumor site, offer targeted treatment but may still cause unintended cytotoxicity. This review explores combination of bioorthogonal reactions with prodrug strategies to improve safety and efficacy.

Language: Английский

Citations

0

Emerging Promise of Green Synthesized Metallic Nanoparticles for the Management of Neurological Disorders DOI

Zahra Esmaeili Moghaddam,

Samin Hamidi, Maryam Azarfarin

et al.

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 31(5), P. 344 - 359

Published: Oct. 14, 2024

The management of neurological disorders is very challenging due to the presence bloodbrain barrier (BBB) that prevents entry drugs into central nervous system (CNS). advancement metallic nanoparticles (NPs) provides a novel direction for treatment disorders. However, there significant concern regarding toxic effects metal NPs on biological tissues like brain. green synthesis strategy offers superior alternative traditional methods development NPs. Notable and oxide can be produced using various bio-reductants derived from natural sources such as plant tissues, fungi, bacteria, yeast, alga. These agents play double roles they expedite reduction process act capping stabilizing agents. In this paper, we discuss major physical barriers limiting transport therapeutics CNS. Moreover, special focus given unique features synthesized therapeutic purposes in insights provided will guide future research toward better outcomes facilitate innovative treatments

Language: Английский

Citations

0