Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity DOI

Srishti Chakraborty,

Souvik Debnath, Kailas Mahipal Malappuram

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via solvent casting method and cross-linked alkaline solution. Sodium hydroxide facilitated deprotonation, leading increased intramolecular hydrogen bonding mechanical properties. The remained intact for 30 days environments. A systematic study revealed gradual increase the output voltage from 0.9 1.8 V under external force (1-16 N). In addition, showed remarkable antibacterial anti-inflammatory activities ultrasound stimulation inhibition of inflammatory cytokines. films also displayed enhanced cellular proliferation ∼5-fold faster migration NIH3T3 cells US stimulation. Overall, this work presents robust, biocompatible, wearable device that can transform biomechanical energy into electrical pulses modulation cell fate processes other bioactivities.

Language: Английский

Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity DOI

Srishti Chakraborty,

Souvik Debnath, Kailas Mahipal Malappuram

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via solvent casting method and cross-linked alkaline solution. Sodium hydroxide facilitated deprotonation, leading increased intramolecular hydrogen bonding mechanical properties. The remained intact for 30 days environments. A systematic study revealed gradual increase the output voltage from 0.9 1.8 V under external force (1-16 N). In addition, showed remarkable antibacterial anti-inflammatory activities ultrasound stimulation inhibition of inflammatory cytokines. films also displayed enhanced cellular proliferation ∼5-fold faster migration NIH3T3 cells US stimulation. Overall, this work presents robust, biocompatible, wearable device that can transform biomechanical energy into electrical pulses modulation cell fate processes other bioactivities.

Language: Английский

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