Enhanced cognitive function in mice through intranasal delivery of sinapic acid via chitosan-coated solid lipid nanoparticles DOI

A Prabakaran,

Debarati Rakshit,

Inklisan Patel

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 675, P. 125565 - 125565

Published: April 1, 2025

Language: Английский

Quercetin-functionalized nanomaterials: Innovative therapeutic avenues for Alzheimer's disease management DOI
Jinjin Pei,

Ranil Vikraman Kumarasamy,

Selvaraj Jayaraman

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102665 - 102665

Published: Jan. 1, 2025

Language: Английский

Citations

3
Advances in Lipid Nanoparticle‐Based Disease Treatment DOI Open Access
Yujie Zhou,

Qiqi Ge,

Xin Wang

et al.

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Lipid nanoparticles (LNPs) have emerged as a transformative platform for the targeted delivery of therapeutic agents, revolutionizing treatment paradigms across spectrum diseases. Since inception liposomes in 1960s, lipid‐based nanotechnology has evolved to address limitations such poor bioavailability, off‐target effects, and instability, thereby enhancing efficacy safety drug administration. This review highlights latest advancements LNPs technology, focusing on their application cancer therapy, gene infectious disease management, glaucoma, other clinical areas. Recent studies underscore potential deliver messenger RNA (mRNA) small interfering (siRNA) precise genetic intervention, exemplified by breakthroughs interference CRISPR‐Cas9 genome editing. Additionally, been successfully employed ameliorate conditions, demonstrating versatility addressing both acute chronic disorders. However, challenges persist concerning large‐scale manufacturing, long‐term stability, comprehensive evaluations. Future research must focus optimizing formulations, exploring synergistic combinations with existing therapies, expanding scope treatable The integration into personalized medicine exploration applications diseases represent promising avenues further investigation. are poised play an increasingly central role development next‐generation therapeutics.

Language: Английский

Citations

1
Advancing Nanomaterial-Based Strategies for Alzheimer’s Disease: A Perspective DOI Creative Commons
Hong Zhou, Xiuhua Yin,

G. Y. Zhang

et al.

JACS Au, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Alzheimer's disease (AD) is a complex neurodegenerative disorder and the most common cause of dementia. By 2050, number AD cases projected to exceed 131 million, placing significant strain on healthcare systems economies worldwide. The pathogenesis multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, inflammation. Despite extensive research, complexity these potentially entangled mechanisms has hindered development treatments that can reverse progression. Nanotechnology, leveraging unique physical, electrical, magnetic, optical properties nanomaterials, emerged promising approach for treatment. In this Perspective, we first outlined major current pathogenic hypotheses then reviewed recent advances in nanomaterials addressing hypotheses. We have also discussed challenges translating into clinical applications proposed future directions, particularly multifunctional multitarget enhance their therapeutic efficacy applicability

Language: Английский

Citations

0
Enhanced cognitive function in mice through intranasal delivery of sinapic acid via chitosan-coated solid lipid nanoparticles DOI

A Prabakaran,

Debarati Rakshit,

Inklisan Patel

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 675, P. 125565 - 125565

Published: April 1, 2025

Language: Английский

Citations

0