ZrS2 Nanoparticles Embedded in Chitosan-Based Hydrogel for the Electrochemical Detection of Antimalarial Drug Amodiaquine in Serum Samples DOI
D. Ramasamy,

Gopika Mukundan,

Manaswini Ravipati

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

In this study, we report the synthesis of ZrS2 nanoparticles embedded in a chitosan-based hydrogel (ZrS2/CS hydrogel) for electrochemical detection amodiaquine (ADQ). The are synthesized via hydrothermal technique. Morphologically, transmission electron microscopy images show that agglomerated to form nanoclusters. Scanning reveal porous interconnected structure stacked layer with have high surface area and electrochemically active sites. These enhanced transport during redox process. Differential pulse voltammetry is employed detect ADQ wide linear range 0.02 nM 2 μM. sensitivity calculated be 1.138 μA/nM limit 0.4 quantification 1.33 nM. possible mechanism behind performance can ascribed oxidation ADQ, its corresponding quinone-imine, improved interaction between electrode electrolyte solution, leading transfer more stable signals sensing. sensor developed here has highly selective response toward over other interferents such as NaCl, urea, uric acid, glucose, ascorbic dopamine. simulated human serum, shows recovery rate from 98.58 100.62%, suggesting potential developing sensors. repeatability reproducibility results ZrS2/CS excellent consistent results, relative standard deviations 3.41 3.46%, respectively, further affirming reliability sensor. This approach opens up future research directions detecting various analytes point-of-care biomedical devices.

Language: Английский

ZrS2 Nanoparticles Embedded in Chitosan-Based Hydrogel for the Electrochemical Detection of Antimalarial Drug Amodiaquine in Serum Samples DOI
D. Ramasamy,

Gopika Mukundan,

Manaswini Ravipati

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

In this study, we report the synthesis of ZrS2 nanoparticles embedded in a chitosan-based hydrogel (ZrS2/CS hydrogel) for electrochemical detection amodiaquine (ADQ). The are synthesized via hydrothermal technique. Morphologically, transmission electron microscopy images show that agglomerated to form nanoclusters. Scanning reveal porous interconnected structure stacked layer with have high surface area and electrochemically active sites. These enhanced transport during redox process. Differential pulse voltammetry is employed detect ADQ wide linear range 0.02 nM 2 μM. sensitivity calculated be 1.138 μA/nM limit 0.4 quantification 1.33 nM. possible mechanism behind performance can ascribed oxidation ADQ, its corresponding quinone-imine, improved interaction between electrode electrolyte solution, leading transfer more stable signals sensing. sensor developed here has highly selective response toward over other interferents such as NaCl, urea, uric acid, glucose, ascorbic dopamine. simulated human serum, shows recovery rate from 98.58 100.62%, suggesting potential developing sensors. repeatability reproducibility results ZrS2/CS excellent consistent results, relative standard deviations 3.41 3.46%, respectively, further affirming reliability sensor. This approach opens up future research directions detecting various analytes point-of-care biomedical devices.

Language: Английский

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