International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(18), P. 10028 - 10028
Published: Sept. 17, 2021
The
gut
microbiome
has
attracted
increasing
attention
from
researchers
in
recent
years.
microbiota
can
have
a
specific
and
complex
cross-talk
with
the
host,
particularly
central
nervous
system
(CNS),
creating
so-called
“gut–brain
axis”.
Communication
between
gut,
intestinal
microbiota,
brain
involves
secretion
of
various
metabolites
such
as
short-chain
fatty
acids
(SCFAs),
structural
components
bacteria,
signaling
molecules.
Moreover,
an
imbalance
composition
modulates
immune
function
tissue
barriers
blood–brain
barrier
(BBB).
Therefore,
aim
this
literature
review
is
to
describe
how
gut–brain
interplay
may
contribute
development
neurological
disorders,
combining
fields
gastroenterology
neuroscience.
We
present
findings
concerning
effect
altered
on
neurodegeneration
neuroinflammation,
including
Alzheimer’s
Parkinson’s
diseases,
well
multiple
sclerosis.
impact
pathological
shift
selected
neuropsychological
i.e.,
major
depressive
disorders
(MDD)
autism
spectrum
disorder
(ASD),
also
discussed.
Future
research
balanced
axis
would
help
identify
new
potential
opportunities
for
therapeutic
interventions
presented
diseases.
Molecular Neurobiology,
Journal Year:
2020,
Volume and Issue:
57(12), P. 5026 - 5043
Published: Aug. 22, 2020
Understanding
how
gut
flora
influences
gut-brain
communications
has
been
the
subject
of
significant
research
over
past
decade.
The
broadening
term
"microbiota-gut-brain
axis"
from
"gut-brain
underscores
a
bidirectional
communication
system
between
and
brain.
microbiota-gut-brain
axis
involves
metabolic,
endocrine,
neural,
immune
pathways
which
are
crucial
for
maintenance
brain
homeostasis.
Alterations
in
composition
microbiota
associated
with
multiple
neuropsychiatric
disorders.
Although
causal
relationship
dysbiosis
neural
dysfunction
remains
elusive,
emerging
evidence
indicates
that
may
promote
amyloid-beta
aggregation,
neuroinflammation,
oxidative
stress,
insulin
resistance
pathogenesis
Alzheimer's
disease
(AD).
Illustration
mechanisms
underlying
regulation
by
pave
way
developing
novel
therapeutic
strategies
AD.
In
this
narrative
review,
we
provide
an
overview
their
dysregulation
Novel
insights
into
modification
as
preventive
or
approach
AD
highlighted.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(20), P. 7551 - 7551
Published: Oct. 13, 2020
The
gut
microbiome
acts
as
an
integral
part
of
the
gastrointestinal
tract
(GIT)
that
has
largest
and
vulnerable
surface
with
desirable
features
to
observe
foods,
nutrients,
environmental
factors,
well
differentiate
commensals,
invading
pathogens,
others.
It
is
well-known
a
strong
connection
central
nervous
system
(CNS)
in
context
health
disease.
A
healthy
diverse
microbes
vital
for
normal
brain
functions
emotional
behaviors.
In
addition,
CNS
controls
most
aspects
GI
physiology.
molecular
interaction
between
gut/microbiome
complex
bidirectional,
ensuring
maintenance
homeostasis
proper
digestion.
Besides
this,
several
mechanisms
have
been
proposed,
including
endocrine,
neuronal,
toll-like
receptor,
metabolites-dependent
pathways.
Changes
bidirectional
relationship
GIT
are
linked
pathogenesis
neurological
disorders;
therefore,
microbiota/gut-and-brain
axis
emerging
widely
accepted
concept.
this
review,
we
summarize
recent
findings
supporting
role
microbiota
immune
on
development
disorders.
highlight
advances
improving
diseases
by
probiotics/prebiotics/synbiotics
fecal
transplantation
via
concept
gut–brain
axis.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Nutrients,
Journal Year:
2020,
Volume and Issue:
13(1), P. 37 - 37
Published: Dec. 24, 2020
For
years,
it
has
been
reported
that
Alzheimer’s
disease
(AD)
is
the
most
common
cause
of
dementia.
Various
external
and
internal
factors
may
contribute
to
early
onset
AD.
This
review
highlights
a
contribution
disturbances
in
microbiota–gut–brain
(MGB)
axis
development
Alteration
gut
microbiota
composition
determined
by
increase
permeability
barrier
immune
cell
activation,
leading
impairment
blood–brain
function
promotes
neuroinflammation,
neuronal
loss,
neural
injury,
ultimately
Numerous
studies
have
shown
plays
crucial
role
brain
changes
behavior
individuals
formation
bacterial
amyloids.
Lipopolysaccharides
amyloids
synthesized
can
trigger
cells
residing
activate
response
neuroinflammation.
Growing
experimental
clinical
data
indicate
prominent
dysbiosis
microbiota–host
interactions
Modulation
with
antibiotics
or
probiotic
supplementation
create
new
preventive
therapeutic
options
Accumulating
evidences
affirm
research
on
MGB
involvement
AD
necessary
for
treatment
targets
therapies
Acta Pharmaceutica Sinica B,
Journal Year:
2021,
Volume and Issue:
11(12), P. 4045 - 4054
Published: March 27, 2021
Ferroptosis
is
a
non-apoptotic
regulated
cell
death
caused
by
iron
accumulation
and
subsequent
lipid
peroxidation.
Currently,
the
therapeutic
role
of
ferroptosis
on
cancer
gaining
increasing
interest.
Baicalin
an
active
component
in
Frontiers in Aging Neuroscience,
Journal Year:
2021,
Volume and Issue:
13
Published: May 28, 2021
Alzheimer's
disease
(AD)
is
the
most
common
age-related
progressive
neurodegenerative
disease,
characterized
by
a
decline
in
cognitive
function
and
neuronal
loss,
caused
several
factors.
Numerous
clinical
experimental
studies
have
suggested
involvement
of
gut
microbiota
dysbiosis
patients
with
AD.
The
altered
can
influence
brain
behavior
through
microbiota-gut-brain
axis
via
various
pathways
such
as
increased
amyloid-β
deposits
tau
phosphorylation,
neuroinflammation,
metabolic
dysfunctions,
chronic
oxidative
stress.
With
no
current
effective
therapy
to
cure
AD,
modulation
may
be
promising
therapeutic
option
prevent
or
delay
onset
AD
counteract
its
progression.
Our
present
review
summarizes
alterations
pathogenetic
roles
mechanisms
microbiota-targeted
therapies
for
Understanding
between
will
help
decipher
pathogenesis
from
novel
perspectives
shed
light
on
strategies
