Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: Efficacies and mechanisms

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 225, P. 107843 - 107843

Published: April 1, 2021

Language: Английский

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Food Ingredients and Active Compounds against the Coronavirus Disease (COVID-19) Pandemic: A Comprehensive Review

Foods, Journal Year: 2020, Volume and Issue: 9(11), P. 1701 - 1701

Published: Nov. 20, 2020

As media reports have noted, the COVID-19 pandemic has accelerated market mainstreaming of immune-boosting food bioactives, supplements, and nutraceuticals. However, most studies reporting on potential bioactives against transmission been uploaded as preprints with little opportunity to revise content for benefit impact. The current review discusses best evidence information underpinning role ingredients bioactive compounds in supporting immune functions humans animals, specifically prevention treatment disease. Up now, some from randomized population clinical trials suggested that vitamin D levels may be linked severity. Numerous theoretical pointed polyphenols particularly flavonoids inhibitors SARS-CoV-2 infection. There is also inconclusive support future use β-glucan address due part variability response arising heterogeneity polysaccharide branch chain length different sources absence a standardized extraction method. To confirm promising outcomes hypotheses compounds, more controlled are needed. results such would profound effect prospects supplements nutraceuticals prophylaxis serve help consumers protect themselves during post-lockdown recovery era.

Language: Английский

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Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID‐19: A review

Phytotherapy Research, Journal Year: 2020, Volume and Issue: 35(3), P. 1298 - 1312

Published: Oct. 9, 2020

The whole world is entangled by the coronavirus disease (COVID‐19) pandemic caused severe acute respiratory syndrome 2 (SARS‐CoV‐2), people are dying in thousands each day, and without an actual medication, it seems not possible for bringing this global health crisis to a stop. Natural products have been constant use since ancient times proven time be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua , Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua Saposhnikoviae divaricate, Tinospora cordifolia etc. shown promising inhibitory effect against coronavirus. Several molecules, including acacetin, amentoflavone, allicin, blancoxanthone, curcumin, daidzein, diosmin, epigallocatechin‐gallate, emodin, hesperidin, herbacetin, hirsutenone, iguesterin, jubanine G, kaempferol, lycorine, pectolinarin, phloroeckol, silvestrol, tanshinone I, taxifolin, rhoifolin, xanthoangelol E, zingerol could also potential drug candidates COVID‐19. Moreover, these show effects influenza‐parainfluenza viruses, syncytial virus, (SARS), Middle East (MERS‐CoV). Here, we reported 93 antiviral which area of research discovery.

Language: Английский

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Traditional Chinese medicine in COVID-19

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(11), P. 3337 - 3363

Published: Sept. 20, 2021

COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread across the globe, posing an enormous threat to public health and safety. Traditional Chinese medicine (TCM), in combination with Western (WM), made important lasting contributions battle against COVID-19. In this review, updated clinical effects potential mechanisms of TCM, presented newly recognized three distinct phases disease, are summarized discussed. By integrating available preclinical evidence, efficacies underlying TCM on COVID-19, including highly recommended patent medicines formulas, described a panorama. We hope that comprehensive review not only provides reference for care professionals recognize significant but also serves as evidence-based in-depth summary analysis facilitate understanding true scientific value TCM.

Language: Английский

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Exploration of natural compounds with anti-SARS-CoV-2 activityviainhibition of SARS-CoV-2 Mpro

Briefings in Bioinformatics, Journal Year: 2020, Volume and Issue: 22(2), P. 1361 - 1377

Published: Nov. 27, 2020

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a dreaded pandemic in lack of specific therapeutic agent. SARS-CoV-2 Mpro, an essential factor viral pathogenesis, recognized as prospective target drug discovery against SARS-CoV-2. To tackle this pandemic, Food and Drug Administration-approved drugs are being screened Mpro via silico vitro methods to detect the best conceivable candidates. However, identification natural compounds with anti-SARS-CoV-2 potential have been recommended rapid effective alternative for development. Thereof, total 653 were identified from NP-lib database at MTi-OpenScreen webserver using virtual screening approach. Subsequently, top four compounds, i.e. 2,3-Dihydroamentoflavone (ZINC000043552589), Podocarpusflavon-B (ZINC000003594862), Rutin (ZINC000003947429) Quercimeritrin 6"-O-L-arabinopyranoside (ZINC000070691536), co-crystallized N3 inhibitor reference ligand considered stringent molecular docking after geometry optimization DFT method. Each compound exhibited substantial energy >-12 kcal/mol contacts residues, including catalytic dyad (His41 Cys145) substrate binding active pocket inhibitor. The further scrutinized absorption, distribution, metabolism, excretion - toxicity (ADMET), quantum chemical calculations, combinatorial simulations hybrid QM/MM approaches. Convincingly, collected results support potent druglikeness strong affinity Mpro. Hence, selected advocated inhibitors can be utilized development infection.

Language: Английский

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Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review

Bioresource Technology Reports, Journal Year: 2020, Volume and Issue: 13, P. 100623 - 100623

Published: Dec. 29, 2020

Language: Английский

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The SARS‐CoV‐2 main protease (M^pro): Structure, function, and emerging therapies for COVID‐19

MedComm, Journal Year: 2022, Volume and Issue: 3(3)

Published: July 14, 2022

The main proteases (M

Language: Английский

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Current Prevention of COVID-19: Natural Products and Herbal Medicine

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Oct. 16, 2020

Starting from December 2019, novel coronavirus disease 2019 (COVID-19) pandemic has caused tremendous economic loss and unprecedented health crisis across the globe. While development of cure is at full speed, less attention fewer effort have been spent on prevention this rapidly spreading respiratory infectious disease. Although so far, several vaccine candidates advanced into clinical trials, limited data released regarding efficacy safety in human, not mention long-term effectiveness those vaccines remain as open question yet. Natural products herbal medicines historically used for acute infection generally show acceptable toxicity. The favorable stability oral formulation ease scaling up manufacture make it ideal candidate prophylactic. Hereby, we summarized most recent advance SARS-CoV-2 including well experimental prophylactics. Mainly, reviewed natural showing inhibitory effect human coronavirus, discussed lately COVID-19, especially focused already approved by regulatory agency with identifiable patent number. We demonstrated that to fill response gap between appropriate treatment commercially available vaccine, repurposing prophylactic will be a vigorous approach stop or least slow down transmission. In interest public health, lend officials better control current pandemic.

Language: Английский

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Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 150, P. 113041 - 113041

Published: May 6, 2022

Lung diseases including chronic obstructive pulmonary disease (COPD), infections like influenza, acute respiratory distress syndrome (ARDS), asthma and pneumonia lung cancer (LC) are common causes of sickness death worldwide due to their remoteness, cold harsh climatic conditions, inaccessible health care facilities. Many drugs have already been proposed for the treatment diseases. Few them in clinical trials potential cure infectious Plant extracts or herbal products extensively used as Traditional Chinese Medicine (TCM) Indian Ayurveda. Moreover, it has involved inhibition certain genes/protiens effects promote regulation signaling pathways. Natural remedies scientifically proven with remarkable bioactivities considered a cheap safe source disease. This comprehensive review highlighted literature about traditional plants metabolites applications through experimental models humans. information mode mechanism studied retrieved by Google Scholar, ScienceDirect, SciFinder, Scopus Medline PubMed resources against In vitro, vivo computational studies explained natural derived from (like flavonoids, alkaloids, terpenoids) different types Probiotics also biologically active therapeutics cancer, anti-inflammation, antiplatelet, antiviral, antioxidants associated The results mentioned repurposed especially SARS-CoV-2 should be evaluated more advance applications, biological system, need validated so that we may able retrieve most challenging SARS-CoV-2.

Language: Английский

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Antiviral Activity Exerted by Natural Products against Human Viruses

Viruses, Journal Year: 2021, Volume and Issue: 13(5), P. 828 - 828

Published: May 4, 2021

Viral infections are responsible for several chronic and acute diseases in both humans animals. Despite the incredible progress human medicine, viral diseases, such as acquired immunodeficiency syndrome, respiratory syndromes, hepatitis, still associated with high morbidity mortality rates humans. Natural products from plants or other organisms a rich source of structurally novel chemical compounds including antivirals. Indeed, traditional many pathological conditions have been treated using plant-derived medicines. Thus, identification alternative antiviral agents is critical importance. In this review, we summarize phytochemicals activity against viruses their potential application treating preventing disease.

Language: Английский

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