Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 10(37), P. 7328 - 7348

Published: Jan. 1, 2022

Chitosan has been widely used to assemble different types of oral colon-targeted delivery systems, which attract great attention in the polyphenols colon for treatment and non-colon diseases.

Language: Английский

---

Preparation and characterization of colon-targeted pH/Time-dependent nanoparticles using anionic and cationic polymethacrylate polymers

European Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 171, P. 106122 - 106122

Published: Jan. 7, 2022

Inflammatory bowel disease (IBD), which is a chronic inflammatory of the gastrointestinal system, has two subtypes: Ulcerative Colitis (UC) and Crohn's Disease (CD). Only pH-sensitive drug delivery systems are commonly utilized for treatment IBD, but their effectiveness frequently obstructed by change in intestinal pH. To overcome inadequacy only pH-dependent systems, we developed vitro evaluated both pH- time-dependent nanoparticles loaded budesonide (BUD) IBD this study. Anionic polymethacrylate was as polymer whereas cationic sustained release polymer. Nanoparticles were prepared through single oil-in-water emulsion/solvent evaporation method. The encapsulation efficiency, mean particle size, zeta potential, polydispersity index (PDI), profiles, kinetics, stability these investigated. In all formulations, sizes below 250 nm PDI values between 0.1 0.3. containing 90% anionic-10% polymers inhibited burst BUD under acidic conditions exhibited at neutral Consequently, medication BUD-loaded pH may be promising choice system.

Language: Английский

---

Comprehensive analysis of endoplasmic reticulum stress-associated genes signature of ulcerative colitis

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 23, 2023

Background Endoplasmic reticulum stress (ERS) is a critical factor in the development of ulcerative colitis (UC); however, underlying molecular mechanisms remain unclear. This study aims to identify pivotal related ERS UC pathogenesis and provide novel therapeutic targets for UC. Methods Colon tissue gene expression profiles clinical information patients healthy controls were obtained from Gene Expression Omnibus (GEO) database, ERS-related set was downloaded GeneCards analysis. Weighted co-expression network analysis (WGCNA) differential utilized modules genes associated with A consensus clustering algorithm used classify patients. The CIBERSORT employed evaluate immune cell infiltration. Set Variation Analysis (GSVA), Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) explore potential biological mechanisms. external sets validate relationship biologics. Small molecule compounds predicted using Connectivity Map (CMap) database. Molecular docking performed simulate binding conformation small key targets. Results identified 915 differentially expressed (DEGs) 11 (ERSRGs) colonic mucosa controls, these had good diagnostic value highly correlated. Five small-molecule drugs sharing tubulin inhibitors identified, including albendazole, fenbendazole, flubendazole, griseofulvin, noscapine, among which noscapine exhibited highest correlation high affinity Active 10 ERSRGs large number cells, also colon mucosal invasion active Significant differences patterns infiltration abundance observed subtypes. Conclusion results suggest that plays vital role pathogenesis, may be promising agent by affecting ERS.

Language: Английский

---

Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives

Drug Delivery, Journal Year: 2023, Volume and Issue: 30(1)

Published: June 8, 2023

The pharmacological approach to treating gastrointestinal diseases is suffering from various challenges. Among such diseases, ulcerative colitis manifests inflammation at the colon site specifically. Patients notably exhibit thin mucus layers that offer increased permeability for attacking pathogens. In majority of patients, conventional treatment options fail in controlling symptoms disease leading distressing effects on quality life. Such a scenario due failure therapies target loaded moiety into specific diseased sites colon. Targeted carriers are needed address this issue and enhance drug effects. Conventional nanocarriers mostly readily cleared have nonspecific targeting. To accumulate desired concentration therapeutic candidates inflamed area colon, smart nanomaterials with responsive nature been explored recently include pH responsive, reactive oxygen species (ROS), enzyme thermo - nanocarrier systems. formulation nanotechnology scaffolds has resulted selective release drugs, avoiding systemic absorption limiting undesired delivery targeting drugs healthy tissues. Recent advancements field systems fabrication multi-responsive i.e. dual derivitization biological tissues nanocarrier's interaction. addition, it also led efficient significant cellular uptake moieties. Herein, we highlighted latest status system, its applications on-demand colitis, prospects underpinned.

Language: Английский

---

Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 10, 2024

Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate potential anti-inflammatory anti-oxidative properties. However, most lectin receptors bind free monosaccharide ligands with relatively low affinity Se species induce side effects beyond very narrow range dosage. This has contributed to poorly explored therapies for IBD that combine mannose target epithelial cells (IECs) normalization gut homeostasis. Herein, facile safe strategy ulcerative colitis (UC) treatment was developed using optimized, mannose-functionalized nanoparticles (M-SeNPs) encapsulated within colon-targeted hydrogel delivery system containing alginate (SA) chitosan (CS). biocompatible nanosystem efficiently taken up by IECs led increased expression Se-dependent glutathione peroxidases (GPXs), thereby modulating IECs' immune response. Using mouse model DSS-induced colitis, (CS/SA)-embedding M-SeNPs (C/S-MSe) were found mitigate oxidative stress inflammation through the inhibition NF-kB pathway in colon. stabilized mucosal ameliorated colitis-related symptoms, providing new approach IBD.

Language: Английский

---