International Food Research Journal,
Journal Year:
2024,
Volume and Issue:
31(3), P. 770 - 783
Published: July 1, 2024
Polyphenols
from
kiwi
by-products
(PKWP)
have
been
previously
reported
to
an
inhibitory
effect
on
cancer
cells;
but,
the
potential
anti-cancer
mechanism
remains
unknown.
Metabolic
alterations
in
cells
provide
bioenergy
and
substances
for
uncontrolled
proliferation
development,
interfering
with
metabolic
pathways
has
regarded
as
effective
impeding
progression.
Cancer
are
also
characterised
by
a
relatively
higher
level
of
oxidative
stress
enhanced
antioxidant
defence
system,
facilitating
multiple
stages
tumorigenesis.
Anti-cancer
mechanisms
PKWP
based
redox
homeostasis
HepG2
were
thus
investigated
present
work.
The
results
showed
that
effectively
decreased
cell
viability
concentration-dependent
manner.
caused
disorders
cells,
significantly
affected
content
about
32
metabolites.
mainly
inhibited
saccharide
synthesis
glycolysis,
restricted
utilisation
amino
acids.
stimulated
ROS
production,
lipid
peroxidation,
resulting
damage.
down-regulated
activities
T-SOD
CAT,
GSH,
protein
expressions
HO-1
COX-2,
weakening
cellular
capacity.
Thus,
could
exert
prominent
activity
disrupting
homeostasis,
induction
stress.
These
findings
will
evidence
further
elucidation
PKWP,
application
natural
ingredient
functional
food,
cosmetic,
pharmaceutical
industries.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(3), P. e42412 - e42412
Published: Feb. 1, 2025
Alzheimer's
disease
(AD)
is
a
progressive
condition
marked
by
multiple
underlying
mechanisms.
Therefore,
the
investigation
of
natural
products
that
can
target
pathways
presents
potential
gate
for
understanding
and
management
AD.
This
study
aimed
to
assess
neuroprotective
effects
hydroalcoholic
extract
Dracocephalum
moldavica
(DM)
on
cognitive
impairment,
biomarker
changes,
putative
metabolic
in
rat
model
AD
induced
intracerebroventricular
streptozotocin
(ICV-STZ).
The
DM
was
standardized
quantified
based
examining
total
phenolic,
flavonoid,
rosmarinic
acid,
quercetin
contents
using
colorimetry
high-performance
liquid
chromatography
(HPLC)
methods.
antioxidant
evaluated
2,2-Diphenyl-1-picrylhydrazyl
nitric
oxide
radical
scavenging
assays.
Male
Wistar
rats
were
injected
with
STZ
(3
mg/kg,
single
dose,
bilateral
ICV)
induce
sporadic
(sAD)
model.
Following
induction,
orally
administered
(100,
200,
400
mg/kg/day)
or
donepezil
(5
21
days.
Cognitive
function
assessed
radial
arm
water
maze
behavioral
test.
histopathological
evaluations
conducted
cortex
hippocampus
regions.
Matrix-assisted
laser
desorption/ionization-time
flight
mass
spectrometry
(MALDI-TOF
MS)
used
metabolite
changes
various
brain
significantly
attenuated
dysfunction
ICV-STZ
according
investigations.
Thirty-two
discriminating
metabolites
related
amino
acid
metabolism;
glutamate/gamma-aminobutyric
acid/glutamine
cycle;
nucleotide
lipid
metabolism
(glycerophospholipids,
sphingomyelins,
ceramides,
phosphatidylserines,
prostaglandins),
glucose
identified
brains
sAD
simultaneously
first
time
this
Polyphenols
may
contribute
regulation
these
pathways.
After
treatment
extract,
10
from
32
ones
altered
tissue
sAD,
most
commonly
at
doses
200
mg/kg.
In
conclusion,
demonstrates
upregulation/downregulation
pathophysiological
biomarkers
such
as
adenine,
glycerophosphoglycerol,
inosine,
prostaglandins,
sphingomyelin
sAD.
These
findings
are
consistent
results
outcomes.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(24), P. 5934 - 5934
Published: Dec. 16, 2024
Targeted
metabolomics
and
lipidomics
are
increasingly
utilized
in
clinical
research,
providing
quantitative
comprehensive
assessments
of
metabolic
profiles
that
underlie
physiological
pathological
mechanisms.
These
approaches
enable
the
identification
critical
metabolites
alterations
essential
for
accurate
diagnosis
precision
treatment.
Mass
spectrometry,
combination
with
various
separation
techniques,
offers
a
highly
sensitive
specific
platform
implementing
targeted
settings.
Nevertheless,
challenges
persist
areas
such
as
sample
collection,
quantification,
quality
control,
data
interpretation.
This
review
summarizes
recent
advances
lipidomics,
emphasizing
their
applications
research.
Advancements,
including
microsampling,
dynamic
multiple
reaction
monitoring,
integration
ion
mobility
mass
highlighted.
Additionally,
discusses
importance
standardization
harmonization
successful
implementation.
The
"War
on
Cancer"
began
with
the
National
Cancer
Act
of
1971
and
despite
more
than
50
years
effort
numerous
successes,
there
still
remains
much
work
to
be
done.
major
challenge
complexity
intrinsic
polygenicity
neoplastic
diseases.
Furthermore,
safety
antitumor
therapies
a
concern
given
their
often
off-target
effects.
Although
amount
money
invested
in
research
development
required
introduce
novel
FDA-approved
drug
has
continuously
increased,
likelihood
for
new
cancer
drug's
approval
limited.
One
interesting
alternative
approach,
however,
is
idea
repurposing
old
drugs,
which
both
faster
less
costly
developing
drugs.
Repurposed
drugs
have
potential
address
shortage
added
benefit
that
concerns
are
already
established.
That
being
said,
interactions
other
combination
therapies,
should
tested.
In
this
review,
we
discuss
history
repurposed
some
successes
failures,
as
well
multiple
challenges
obstacles
need
addressed
order
enhance
drugs'
therapies.
Critical Reviews in Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 21
Published: March 4, 2025
Metabolomics
is
an
emerging
interdisciplinary
field
focused
on
the
comprehensive
analysis
of
all
metabolites
within
biological
samples,
making
it
valuable
for
areas
such
as
drug
development,
and
environmental
analysis.
Many
compounds,
including
pharmaceuticals
agrochemicals
that
have
been
extensively
studied
by
metabolomics
are
chiral.
The
intrinsic
chirality
targets
can
lead
to
a
selective
recognition
enantiomers
resulting
in
distinct
pharmacokinetic,
pharmacodynamic
and/or
toxicological
profiles
(enantioselectivity).
Given
captures
instant
snapshot
organism's
metabolic
state,
serves
powerful
tool
investigate
chiral
compounds
understand
enantioselective
effects.
Herein,
systematic
compilation
scientific
literature
was
performed
48
enantioselectivity
studies
using
were
selected.
These
revealed
increasing
focus
pesticides
(77%),
use
animal
models
(59%),
reliance
LC-MS
techniques
(52%),
predominantly
untargeted
approaches
(83%).
Enantioselective
effects
described
most
studies.
This
review
describes
significant
advances
this
highlights
unravel
role
stereochemistry
cellular
metabolism
examination
enantiomer-specific
Furthermore,
elucidates
mechanism
be
further
applied
other
groups
compounds.
