Engineering,
Journal Year:
2024,
Volume and Issue:
40, P. 61 - 69
Published: April 23, 2024
Lianhua
Qingke
tablets,
a
patented
traditional
Chinese
medicine
that
has
validated
clinical
efficacy
for
treating
cough
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
infection,
lack
rigorous
evidence-based
research
evaluating
their
effect
on
long
disease
(COVID)
cough.
A
randomized,
double-blind,
placebo-controlled,
multicenter
study
was
conducted
among
patients
with
COVID
from
19
hospitals
and
23
community
health
centers
in
China.
Patients
were
randomized
1:1
to
receive
either
tablets
or
placebo
orally
14
days
(4
1.84
g,
3
times
day).
The
primary
endpoint
indicator
the
disappearance
of
cough,
remission
also
considered.
Among
482
patients,
480
(full
analysis
set
480;
per-protocol
470;
safety
480)
included
analysis.
According
full
analysis,
time
until
significantly
shorter
trial
group
than
control
group,
significant
increase
14-day
rate.
Accordingly,
group.
change
total
symptom
score
greater
day
7
14,
consistent
results
indicated
visual
analog
scale
(VAS)
evaluation
test
(CET)
scores.
No
serious
adverse
events
recorded
during
study.
improved
symptoms
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4277 - 4277
Published: April 30, 2025
Plant-derived
small
RNAs
(sRNAs)
have
garnered
significant
attention
in
nucleic
acid
therapeutics,
driven
by
their
distinctive
cross-kingdom
regulatory
capabilities
and
extensive
therapeutic
promise.
These
sRNAs
exhibit
a
wide
range
of
pharmacological
effects,
including
pulmonary
protection,
antiviral,
anti-inflammatory,
antitumor
activities,
underscoring
substantial
potential
for
clinical
translation.
A
key
advantage
lies
delivery,
facilitated
plant-specific
nanovesicular
carriers—such
as
plant
exosomes,
herbal
decoctosomes,
bencaosomes—which
protect
from
gastrointestinal
degradation
enable
precise,
tissue-specific
targeting.
This
review
provides
comprehensive
analysis
plant-derived
sRNAs,
detailing
classification,
gene-silencing
mechanisms,
nanovesicle-mediated
delivery
strategies.
It
further
explores
underlying
molecular
mechanisms
major
human
diseases.
Additionally,
we
critically
evaluate
current
technical
challenges
propose
future
directions
to
advance
the
development
precision
therapeutics.
work
aims
offer
robust
theoretical
framework
practical
guidance
advancement
sRNA-based
therapies.
Medicines,
Journal Year:
2024,
Volume and Issue:
11(7), P. 14 - 14
Published: July 18, 2024
Cytokine
storm
(CS)
is
the
main
driver
of
SARS-CoV-2-induced
acute
respiratory
distress
syndrome
(ARDS)
in
severe
coronavirus
disease-19
(COVID-19).
The
pathological
mechanisms
CS
are
quite
complex
and
involve
multiple
critical
molecular
targets
that
turn
self-limited
mild
COVID-19
into
a
life-threatening
concern.
At
present,
vaccines
strongly
recommended
as
safe
effective
treatments
for
preventing
serious
illness
or
death
from
COVID-19.
However,
treatment
options
still
lacking
people
who
at
most
risk
hospitalized
with
disease.
Chinese
herbal
medicines
have
been
shown
to
improve
clinical
outcomes
an
adjunct
therapy,
particular
development
ARDS.
This
review
illustrates
detail
pathogenesis
CS-involved
ARDS
its
associated
key
targets,
cytokines
signalling
pathways.
therapeutic
were
identified
particularly
relation
turning
points
COVID-19,
symptoms
Preclinical
studies
reviewed
effects
together
conventional
therapies
reducing
addressing
CS.
Multiple
formulations,
extracts
single
bioactive
phytochemicals
without
demonstrated
strong
anti-CS
through
mechanisms.
evidence
larger,
well-designed
trials
their
detailed
action
yet
be
well
elucidated.
More
research
warranted
further
evaluate
value
medicine
COVID-19-induced
Acta Pharmaceutica Sinica B,
Journal Year:
2023,
Volume and Issue:
13(11), P. 4502 - 4510
Published: Aug. 7, 2023
Paxlovid
is
a
nirmatrelvir
(NMV)
and
ritonavir
(RTV)
co-packaged
medication
used
for
the
treatment
of
coronavirus
disease
2019
(COVID-19).
The
active
component
NMV
RTV
pharmacokinetic
booster.
Our
work
aimed
to
investigate
drug/herb-drug
interactions
associated
with
provide
mechanism-based
guidance
clinical
use
Paxlovid.
By
using
recombinant
human
cytochrome
P450s
(CYPs),
we
confirmed
that
CYP3A4
3A5
are
major
enzymes
responsible
metabolism.
role
CYP3A
in
metabolism
were
further
verified
Cyp3a-null
mice,
which
showed
deficiency
significantly
suppressed
RTV.
Pregnane
X
receptor
(PXR)
ligand-dependent
transcription
factor
upregulates
CYP3A4/5
expression.
We
next
explored
impact
drug-
herb-mediated
PXR
activation
on
transgenic
mouse
model
expressing
CYP3A4/5.
found
increased
expression,
accelerated
metabolism,
reduced
systemic
exposure
NMV.
In
summary,
our
demonstrated
can
cause
drug
Paxlovid,
suggesting
PXR-activating
drugs
herbs
should
be
cautiously
COVID-19
patients
receiving
Engineered Science,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Jan. 1, 2023
The
current
research
has
revealed
that
Arctium
tomentosum
renowned
pharmacological
potentialities,
including
anti-inflammatory,
anticancer,
antioxidant,
antimicrobial,
and
bioactive
phytochemicals,
phenolic
compounds.
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: June 11, 2024
Abstract
Background
Respiratory
syncytial
virus
(RSV)-induced
lung
inflammation
is
one
of
the
main
causes
hospitalization
and
easily
disruption
intestinal
homeostasis
in
infants,
thereby
resulting
a
negative
impact
on
their
development.
However,
current
clinical
drugs
are
not
satisfactory.
Zedoary
turmeric
oil
injection
(ZTOI),
patented
traditional
Chinese
medicine
(TCM),
has
been
used
for
management
inflammatory
diseases.
its
vivo
efficacy
against
RSV-induced
underlying
mechanism
remain
unclear.
Purpose
The
present
study
was
designed
to
confirm
ZTOI
disorders
RSV-infected
young
mice
explore
potential
mechanism.
Study
design
methods
Lung
induced
by
RSV,
cytokine
antibody
arrays
were
clarify
effectiveness
RSV
pneumonia.
Subsequently,
key
therapeutic
targets
pneumonia
identified
through
multi-factor
detection
further
confirmed.
material
basis
target
tissues
determined
non-target
mass
spectrometry.
After
confirming
that
pharmacological
substances
can
reach
intestine,
we
16S
rRNA-sequencing
technology
effect
bacteria.
Results
In
mouse
model,
significantly
reduced
levels
serum
myeloperoxidase,
amyloid
A,
C-reactive
protein,
thymic
stromal
lymphoprotein;
inhibited
mRNA
expression
IL-10
IL-6;
decreased
pathological
changes
lungs.
Immunofluorescence
qPCR
experiments
showed
load
According
arrays,
platelet
factor
4
(PF4),
weak
chemotactic
mainly
synthesized
megakaryocytes,
concentration-dependent
change
affected
ZTOI,
which
could
be
exert
anti-inflammatory
effects.
Additionally,
sesquiterpenes
enriched
lungs
intestines,
exerting
regulatory
effects
gut
microbiota.
Conclusion
protect
from
via
PF4
regulate
microbiota
disorder
sesquiterpenes,
provides
reference
application
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 12, 2024
Introduction
Screening
for
effective
antiviral
compounds
from
traditional
Mongolian
medicine
not
only
aids
in
the
research
of
mechanisms
medicines,
but
is
also
significant
importance
development
new
drugs
targeting
influenza
A
virus.
Our
study
aimed
to
establish
high-throughput,
rapid
screening
methods
against
virus
abundant
resources
medicine.
Methods
The
use
GFP-based
reporter
viruses
plays
a
pivotal
role
by
enabling
and
precise
identification
that
inhibit
viral
replication.
Herein,
was
used
identify
potent
anti-influenza
within
Results
led
discovery
three
active
compounds:
Cardamonin,
Curcumin,
Kaempferide,
all
which
exhibited
properties
vitro
.
Subsequent
analysis
confirmed
their
effectiveness
largely
due
stimulation
signaling
pathways
host
cells,
rather
than
direct
interference
with
components,
such
as
polymerase.
Discussion
This
showcased
high-throughput
unearth
agents
medicine,
contains
rich
deserves
further
exploration.
Despite
certain
limitations,
fluorescent
present
substantial
potential
drug
high
throughput
efficiency.
