Engineering,
Journal Year:
2024,
Volume and Issue:
40, P. 61 - 69
Published: April 23, 2024
Lianhua
Qingke
tablets,
a
patented
traditional
Chinese
medicine
that
has
validated
clinical
efficacy
for
treating
cough
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
infection,
lack
rigorous
evidence-based
research
evaluating
their
effect
on
long
disease
(COVID)
cough.
A
randomized,
double-blind,
placebo-controlled,
multicenter
study
was
conducted
among
patients
with
COVID
from
19
hospitals
and
23
community
health
centers
in
China.
Patients
were
randomized
1:1
to
receive
either
tablets
or
placebo
orally
14
days
(4
1.84
g,
3
times
day).
The
primary
endpoint
indicator
the
disappearance
of
cough,
remission
also
considered.
Among
482
patients,
480
(full
analysis
set
480;
per-protocol
470;
safety
480)
included
analysis.
According
full
analysis,
time
until
significantly
shorter
trial
group
than
control
group,
significant
increase
14-day
rate.
Accordingly,
group.
change
total
symptom
score
greater
day
7
14,
consistent
results
indicated
visual
analog
scale
(VAS)
evaluation
test
(CET)
scores.
No
serious
adverse
events
recorded
during
study.
improved
symptoms
Future Integrative Medicine,
Journal Year:
2024,
Volume and Issue:
000(000), P. 000 - 000
Published: Sept. 2, 2024
In
recent
years,
there
has
been
a
notable
shift
towards
holistic
approach
to
human
health,
recognizing
the
importance
of
integrating
essential
nutrients
with
traditional
natural
medicines.
This
review
article
examines
potential
synergy
between
nutrition
and
healing
practices
in
promoting
well-being
disease
prevention.
It
explores
diverse
landscape
medicine
systems
worldwide,
highlighting
their
cultural
significance
accumulated
wisdom
over
generations.
Moreover,
it
sheds
light
on
scientific
foundations
these
remedies,
showcasing
relevance
modern
healthcare.
Traditional
medicines,
often
sourced
from
plants,
animals,
or
minerals,
offer
wide
array
therapeutic
options
addressing
root
causes
rather
than
symptoms
alone.
enduring
sparked
interest
complementing
healthcare
practices,
aiming
for
harmonious
integration
tradition
evidence-based
medicine.
Furthermore,
underscores
critical
role
maintaining
overall
health
preventing
chronic
diseases.
emphasizes
perspective
encompassing
mental,
emotional,
physical
well-being.
The
relationship
is
also
explored,
emphasizing
balanced
diet.
medicines
nutritional
interventions
presents
promising
avenue
comprehensive
advocates
collaborative
research,
interdisciplinary
dialogue,
cross-cultural
exchanges
harness
collective
past
present.
By
embracing
both
we
can
move
achieving
optimal
wellness,
profound
interconnectedness
humans
world.
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Nov. 14, 2024
Abstract
Background
Deciphering
the
in
vivo
processes
of
traditional
Chinese
medicine
(TCM)
is
crucial
for
identifying
new
pharmacodynamic
substances
and
drugs.
Due
to
complexity
diversity
components,
investigating
exposure,
metabolism,
disposition
remains
a
major
challenge
TCM
research.
In
recent
years,
number
non-targeted
smart
mass-spectrometry
(MS)
techniques,
such
as
precise-and-thorough
background-subtraction
(PATBS)
metabolomics,
have
realized
intelligent
identification
components
TCM.
However,
metabolites
characterization
still
largely
relies
on
manual
combination
with
online
databases.
Results
We
developed
scoring
approach
based
structural
similarity
minimal
mass
defect
variations
between
prototypes.
The
current
method
integrates
three
dimensions
spectral
data
including
m/z
,
MS1
MS2,
MS2
fragments,
which
was
sequentially
analyzed
by
R-based
dataset
relevance
bridging
(MDRB)
post-processing
technique.
MDRB
technology
constructed
component
relationship
network
TCM,
significantly
improving
metabolite
efficiency
facilitating
mapping
translational
metabolic
pathways.
By
combining
PATBS
through
this
technology,
we
comprehensive
strategy
identification,
analysis
vivo.
As
proof
concept,
adopted
proposed
investigate
process
Semen
Armeniacae
Amarum
(CKXR)
mice.
Significance
currently
analytical
universally
applicable
demonstrates
its
effectiveness
analyzing
complex
TCMs
vitro
Furthermore,
it
enables
correlation
data,
providing
insights
into
transformations
among
sharing
same
parent
nucleus
structure.
Finally,
platform
publicly
available
(
https://github.com/933ZhangDD/MDRB
)
accelerating
research
scientific
community.
Graphical
International Journal of Current Pharmaceutical Research,
Journal Year:
2023,
Volume and Issue:
unknown, P. 50 - 60
Published: Nov. 15, 2023
The
world
has
been
facing
the
deadly
coronavirus
for
a
stretch
of
period
now
and
with
innovation
latest
research,
development
vaccines
possible.
initial
duration
wherein
were
under
trials
most
opted
choice
was
use
modern
drug
like
Remdesivir
along
other
existing
daily
supplements.
This
review
article
describes
various
pathogenic
mechanism
action
by
which
virus
attacks
replicates
inside
body.
It
briefly
gives
role
allopathy
drugs,
traditional
Ayurvedic
medicines
herbs
act
discrete
mechanism.
also
focuses
on
acting
as
drugs
supplements
could
be
prophylactic
hence
used
management
mild
to
moderate
COVID
conditions.
Herbal
agents
Ocimum
sanctum,
Curcuma
longa,
Withaniasomnifera,
Glycyrrhiza
glabra,
Andrographis
paniculata,
Zingiber
officinale
etc.
can
have
different
antiviral
actions
during
COVID-19
outbreak
shown
good
margin
efficacy.
Phytoconstituents
quercetin,
fenugreek,
liquorice
activities
anti-viral,
anti-inflammatory,
immunomodulatory
action,
is
studied
further
in
silico
modelling
molecular
docking.
significant
these
phytoconstituents
contributed
preventive
described.
Engineering,
Journal Year:
2024,
Volume and Issue:
40, P. 61 - 69
Published: April 23, 2024
Lianhua
Qingke
tablets,
a
patented
traditional
Chinese
medicine
that
has
validated
clinical
efficacy
for
treating
cough
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
infection,
lack
rigorous
evidence-based
research
evaluating
their
effect
on
long
disease
(COVID)
cough.
A
randomized,
double-blind,
placebo-controlled,
multicenter
study
was
conducted
among
patients
with
COVID
from
19
hospitals
and
23
community
health
centers
in
China.
Patients
were
randomized
1:1
to
receive
either
tablets
or
placebo
orally
14
days
(4
1.84
g,
3
times
day).
The
primary
endpoint
indicator
the
disappearance
of
cough,
remission
also
considered.
Among
482
patients,
480
(full
analysis
set
480;
per-protocol
470;
safety
480)
included
analysis.
According
full
analysis,
time
until
significantly
shorter
trial
group
than
control
group,
significant
increase
14-day
rate.
Accordingly,
group.
change
total
symptom
score
greater
day
7
14,
consistent
results
indicated
visual
analog
scale
(VAS)
evaluation
test
(CET)
scores.
No
serious
adverse
events
recorded
during
study.
improved
symptoms
