Cancer Research and Cellular Therapeutics,
Journal Year:
2023,
Volume and Issue:
8(2), P. 01 - 06
Published: March 20, 2023
Background:
Colorectal
cancer
(CRC)
is
a
leading
cause
of
deaths
worldwide.
Key
risk
factors
include
lifestyle,
diet,
inflammation,
and
family
history.
Understanding
molecular
pathways
underlying
CRC
initiation
progression
critical
to
guide
prevention
treatment.
Purpose:
This
review
summarizes
recent
advances
in
screening,
therapy,
future
directions.
Main
body:
New
stool
DNA
panels
blood-based
assays
offer
non-invasive
options
for
early
detection,
though
require
further
validation.
Immuno-
targeted
therapies
matched
tumor
profiles
have
transformed
metastatic
Pembrolizumab
elicits
durable
responses
mismatch
repair-deficient
tumors,
anti-EGFR
antibodies
cetuximab/panitumumab
improve
outcomes
left-sided
RAS/RAF
wild-type
CRC.
Larotrectinib
entrectinib
are
highly
active
NTRK
fusion-positive
Research
focusing
on
new
immunotherapies,
leveraging
the
microbiome,
combining
multi-omics
data
enable
precision
medicine
holds
promise.
Disparities
across
groups
remain
challenge.
Conclusions:
Recent
therapeutic
significantly
improved
survival
patients.
Advances
diagnostics,
next-generation
sequencing,
computational
approaches
will
more
sophisticated
profiling
tailored
therapy
selection.
Realizing
potential
emerging
immunotherapies
integrating
knowledge
microbiome
important
frontiers.
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
379, P. 236 - 250
Published: Jan. 11, 2025
The
recent
approval
of
pembrolizumab
in
recurrent
or
metastatic
cervical
cancer
warrants
further
investigations
into
the
usefulness
immunotherapies
for
more
durable
and
less
radical
interventions.
In
this
study,
targeting
potential
anti-PD-L1-functionalized
immunoliposomes
was
tested
a
3D
vitro
cancer-on-a-chip
model.
Immunolipsomes
were
synthesized
decorated
externally
with
monovalent
anti-PD-L1
Fab'
fragments
commercially
available
atezolizumab.
Cervical
cell
lines
varying
levels
PD-L1
expression
cultured
as
spheroids
embedded
collagen
I
matrix,
treated
under
flow
culture
media.
Flow
cytometry
live-cell
confocal
imaging
used
to
measure
interactions
uptake
untargeted
liposomes
panel
lines.
retained
specific
functionality
regardless
protein
corona
formation
high
serum
environments.
As
such,
expressing
preferentially
internalized
environment
extracellular
matrix
present,
while
low
PD-L1-expressing
showed
no
preference
either
formulation.
Importantly,
treatments
performed
monolayer
cultures
(on
plastic)
differences
between
immuno-
liposome
uptake,
including
way
which
endocytosed
are
trafficked
subcellularly.
This
study
demonstrates
importance
both
active
passive
accumulation
strategies
achieve
nanoparticle
targeting.
Immunoliposomes
remain
promising
platform
development
targeted
nanotherapies
against
cancers.
However,
initial
functional
tests
did
not
translate
directly
biological
performance
should
be
kept
mind
future
formulations.
Furthermore,
model
developed
appeared
useful
visualizing
3D,
live
tissue
represents
cost-effective
reproducible
studies.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(12), P. 5106 - 5131
Published: Nov. 2, 2024
Reactive
oxygen
species
(ROS)-responsive
drug
delivery
systems
(DDSs)
have
garnered
significant
attention
in
cancer
research
because
of
their
potential
for
precise
spatiotemporal
release
tailored
to
high
ROS
levels
within
tumors.
Despite
the
challenges
posed
by
distribution
heterogeneity
and
endogenous
supply
constraints,
this
review
highlights
strategic
alliance
ROS-responsive
DDSs
with
photodynamic
therapy
(PDT),
enabling
selective
leveraging
PDT-induced
enhanced
therapeutic
efficacy.
This
delves
into
biological
importance
progression
treatment.
We
elucidate
detail
operational
mechanisms
linkers,
including
thioether,
thioketal,
selenide,
diselencide,
telluride
aryl
boronic
acids/esters,
as
well
latest
developments
nanomedicines
that
integrate
PDT
strategies.
These
insights
are
intended
inspire
design
innovative
nanocarriers
PDT.
Bioconjugate Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 6, 2025
Sodium
cyanoborohydride
(CBH)
is
commonly
used
as
a
mild
reducing
agent
in
the
reductive
amination
of
aldehydes
and
free
amines.
Within
pharmaceutical
industry,
this
reaction
employed
bioconjugation
proteins
peptides.
Free
cyanide
species
such
HCN
NaCN
are
known
residual
impurities
CBH
that
can
contribute
to
formation
undesired
side
products
including
cyanoamines
cyanohydrins.
In
commercial
processes,
potential
for
bound
cyanated
requires
an
analytical
control
strategy
monitor
mitigate
any
risk
human
health.
Given
these
concerns,
minimization
utmost
priority
be
achieved
through
robust
quantitative
screening
starting
materials
cyanide.
Alternative
mitigation
strategies
purification
containing
pure
less
effective
due
minor
chemical
differences
between
expected
product
species.
Herein,
we
present
simple
chromatographic
assay
quantitation
raw
material
sodium
cyanoborohydride.
Method
development,
robustness
evaluation,
scientific
soundness
assessment
reported
with
excellent
linearity,
accuracy,
precision,
specificity.
Additionally,
method
was
applied
evaluation
supplied
from
10
sources,
none
which
report
specification
within
their
certificate
analysis.
The
measured
vendors
ranged
8
80
mM
concentration,
thereby
confirming
value
materials.
Finally,
demonstrate
impact
on
model
ornithine
glyceraldehyde.
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(14)
Published: July 17, 2024
G
protein-coupled
receptors
(GPCRs)
are
essential
contributors
to
tumor
growth
and
metastasis
due
their
roles
in
immune
cell
regulation.
Therefore,
GPCRs
potential
targets
for
cancer
immunotherapy.
Here,
we
discuss
the
current
understanding
of
signaling
pathways
progression
from
an
immunocellular
perspective.
Additionally,
focus
on
regulating
checkpoint
proteins
involved
evasion.
Finally,
review
progress
clinical
trials
GPCR-targeted
drugs
treatment,
which
may
be
combined
with
immunotherapy
improve
treatment
efficacy.
This
expanded
role
shed
light
mechanisms
underlying
provide
a
novel
perspective
