Hijacking of the nervous system in cancer: mechanism and therapeutic targets

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 6, 2025

The activity of neurons in the vicinity tumors is linked to a spectrum cellular mechanisms, including facilitation tumor cell proliferation, synapse formation, angiogenesis, and macrophage polarization. This review consolidates current understanding neuro-oncological regulation, underscoring nuanced interplay between neurological oncological processes (termed as Cancer-Neuroscience). First, we elucidated how nervous system accelerates growth, metastasis, microenvironment both directly indirectly through action signaling molecules. Importantly, neural also implicated modulating efficacy therapeutic interventions, immunotherapy. On contrary, potentially has suppressive effect on tumorigenesis, further dual-edged role cancer progression. Consequently, targeting specific molecules within regulatory pathways could suppress development. Future research poised explore intricate mechanisms governing neuro-tumor interactions more deeply, while concurrently refining treatment strategies for by crosstalk neurons.

Language: Английский

Recent advances in the bench-to-bedside translation of cancer nanomedicines

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(1), P. 97 - 122

Published: Dec. 14, 2024

Cancer remains a complex and challenging medical problem, driving extensive research efforts. Despite significant progress in understanding its genetic molecular aspects, the quest for effective treatments continues. Nanomedicines have shown great potential revolutionizing cancer treatment by offering targeted controlled drug delivery, reducing side effects, improving patient outcomes. Accordingly, nanomedicines been focus of development clinical translation. As September 2024, search on ClinicalTrials.gov website using term "nanoparticles" revealed numerous ongoing planned trials. Motivated recent advances field, this review explores current frontier nanomedicine. supported chemotherapy, phototherapy sonodynamic therapy, nucleic acid immunotherapy. However, translating into practice has challenged interactions between nanoparticles biological systems, variable permeability retention tumors, safety concerns, difficulty achieving issues with scaling up manufacturing. Perspectives addressing these challenges are offered. Future opportunities nanomedicines, including modifying tumor microenvironment, integrating artificial intelligence big data, targeting new areas, also discussed. This underscores to revolutionize from standpoint.

Language: Английский

Ionic exchange based intracellular self-assembly of pitaya-structured nanoparticles for tumor imaging

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110281 - 110281

Published: July 1, 2024

Language: Английский