Mining of antioxidant sesquiterpene lactones from the aerial parts of Saussurea involucrata with feature-based molecular network strategy DOI

Bo‐Dou Zhang,

Libing Liang, Jingwen Zhao

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108067 - 108067

Published: Dec. 16, 2024

Language: Английский

A synergistic effect of triptolide and curcumin on rheumatoid arthritis by improving cell proliferation and inducing cell apoptosis via inhibition of the IL-17/NF-κB signaling pathway DOI Creative Commons
Chaofeng Zhang,

Yiyang Weng,

Haibin Wang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 112953 - 112953

Published: Sept. 2, 2024

Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune disease. While triptolide (TPL) and curcumin (CUR) are known to have multiple beneficial effects on RA, the combined effect of TPL CUR remains unexplored. This study aimed investigate their synergistic cell proliferation apoptosis via IL-17/NF-κB signaling pathway. The collagen-induced (CIA) rat model was established, showing severe joint synovial damage compared normal rats. Treatment with reduced severity RA in CIA alleviated serum inflammatory cytokines, such as rheumatoid factor, IL-17, TNF-α, IL-1β, IL-6. elevated levels IL-17 NF-κB rats were also inhibited, resistant aggravated by CUR. In vitro, improvement induction observed LPS-stimulated MH7A cells treated CUR, associated inhibition Taken together, may involve relieving symptoms, improving excessive proliferation, inducing resistance, inhibiting

Language: Английский

Citations

4
Sinensetin attenuates LPS-induced acute pulmonary inflammation in mice and RAW264.7 cells by modulating NF-κB p65-mediated immune resistance and STAT3-mediated tissue resilience DOI

Zaibin Xu,

Kongyan Wang,

Hui-Yu Hu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114101 - 114101

Published: Jan. 18, 2025

Language: Английский

Citations

0
Thiolutin, a novel NLRP3 inflammasome inhibitor, mitigates IgA nephropathy in mice DOI
Yun Zhang,

Shuhan Shi,

Changda Lin

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114440 - 114440

Published: March 13, 2025

Language: Английский

Citations

0
Anti-rheumatoid arthritis effects of Caragana acanthophylla Kom. on collagen-induced arthritis and the anti-inflammatory activity of polyphenols as main active components DOI
Lan Pan,

Tianyuan Zhou,

Kailibinur Maimaiti

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119637 - 119637

Published: March 1, 2025

Language: Английский

Citations

0
Baicalin and kaempferol alleviates cuprizone-induced demyelination and microglial activation by inhibiting the STAT3 and NF-κB signaling pathways DOI
Liming Liu, Yufang Zhao,

Jingjing Bu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114592 - 114592

Published: April 3, 2025

Language: Английский

Citations

0
Urolithin a attenuates rheumatoid arthritis by inhibiting inflammation and pyroptosis in fibroblasts via the AMPK/ NF-κB signaling pathway DOI
Hao Chen, Zhen Zhang,

Congcong Lu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114604 - 114604

Published: April 10, 2025

Language: Английский

Citations

0
Traditional Chinese Medicine-Loaded Hydrogels: An Emerging Strategy for the Treatment of Bone Infections DOI Creative Commons
Xin Jin,

Yuchen Yue,

Huaanzi Hu

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 514 - 514

Published: April 14, 2025

Bone infection is a disease that seriously affects patients’ quality of life and physical health. Traditional treatment methods have many drawbacks. Hydrogels loaded with Chinese Medicine (TCM), as an emerging strategy, combine the advantages good biocompatibility hydrogels, adjustable drug release performance, multi-target synergistic TCM, showing great application potential. This article elaborates in detail on research progress hydrogels TCM for bone infections, including classification characteristics mechanism action preparation examples, advantages, challenges prospects faced. The aim to provide new ideas references clinical infections.

Language: Английский

Citations

0
Discovery of soluble epoxide hydrolase inhibitors from Inula britannica: Inhibition kinetics, molecular dynamics simulation, biochemical, and in vitro cell-based studies DOI

Yuanwei Jia,

Na Wang,

S. Hui

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141704 - 141704

Published: March 3, 2025

Language: Английский

Citations

0
From Hit to Lead: Discovery of First-In-Class Furanone Glycoside D228 Derived from Chimonanthus salicifolius for the Treatment of Inflammatory Bowel Disease DOI
Mei‐Lin Tang, Xiaoyu Xiong,

Heyanhao Zhang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(19), P. 17101 - 17123

Published: Sept. 19, 2024

TNFα and related inflammatory factor antibody drugs have been orchestrated for the treatment of bowel disease (IBD). However, elicited inevitable disadvantages small molecule are in an urgent need. Herein, we described discovery, design, synthesis, SAR studies from furanone glycoside compound

Language: Английский

Citations

1
Tulipalin A suppressed the pro-inflammatory polarization of M1 macrophage and mitigated the acute lung injury in mice via interference DNA binding activity of NF-κB DOI
Ke‐Gang Linghu,

Yue-Ting Tuo,

Wen-Qing Cui

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 984, P. 177034 - 177034

Published: Oct. 5, 2024

Language: Английский

Citations

1