Mining of antioxidant sesquiterpene lactones from the aerial parts of Saussurea involucrata with feature-based molecular network strategy DOI

Bo‐Dou Zhang,

Libing Liang, Jingwen Zhao

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108067 - 108067

Published: Dec. 16, 2024

Language: Английский

3-Oxo-11αH-germacra-1(10) E,4Z-dien-12,6α-olide, a sesquiterpene from Artemisia sieversiana, attenuates lipopolysaccharide-induced inflammation via NF-κB/MAPK pathways and oxidative stress via ROS pathway in RAW264.7 cells DOI
Qianqian Ren, Lili Wang, Xin Wang

et al.

Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

Citations

0
Triptolide induces apoptosis of glioma cells by inhibiting NF-κB activation during oxidative stress DOI Creative Commons
Xinglan Li, Yi Shan, Si Wang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 29, 2024

Glioma is a common and fatal malignant primary brain tumor. Radiotherapy first-line chemotherapy have little effect on the survival rate of patients, requiring alternative therapies. The main active ingredient Tripterygium wilfordii Hook. F. triptolide (TP) has been shown to anti-inflammatory anti-proliferative properties, along with wide range anticancer activities. This study aimed investigate molecular mechanisms in glioma treatment through network pharmacology experimental validation. Cell viability was first assessed using Counting Kit-8 (CCK8), followed by cell scratch assay migration ability. Apoptosis-related markers, including TUNEL staining, Bcl-2-associated X protein (Bax), B-cell lymphoma-2 (Bcl-2), were detected. Network used predict key targets glioma, detect its signal pathways, screen components for docking, explore signaling pathways TP. Lastly, immunofluorescence assays ELISA performed elucidate underlying mechanistic pathways. data suggested that TP may inhibit proliferation regulating pathway nuclear factor kappa-B (NF-κB). results showed mechanism involved regulation NF-κB promote generation reactive oxygen species, thereby enhancing oxidative stress response promoting apoptosis.

Language: Английский

Citations

0
Mining of antioxidant sesquiterpene lactones from the aerial parts of Saussurea involucrata with feature-based molecular network strategy DOI

Bo‐Dou Zhang,

Libing Liang, Jingwen Zhao

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108067 - 108067

Published: Dec. 16, 2024

Language: Английский

Citations

0