Published: Jan. 1, 2024
Language: Английский
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357
Published: Feb. 5, 2025
Language: Английский
Citations
6
Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 126999 - 126999
Published: Jan. 1, 2025
Language: Английский
Citations
3
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1043 - 1043
Published: Aug. 6, 2024
Chitosan nanoparticles (CSNPs) are promising vehicles for targeted and controlled drug release. Recognized their biodegradability, biocompatibility, low toxicity, ease of production, CSNPs represent an effective approach to delivery. Encapsulating drugs within (NPs) provides numerous benefits compared free drugs, such as increased bioavailability, minimized toxic side effects, improved delivery, the incorporation additional features like release, imaging agents, combination therapies with multiple drugs. Keys parameters in nanomedicines loading content efficiency. Most current NP systems struggle loading, presenting a significant challenge field. This review summarizes recent research on developing high capacity, focusing various synthesis strategies. It examines CSNP using different materials providing details methods, loadings, encapsulation efficiencies, release profiles, stability, applications Additionally, discusses factors affecting valuable guidelines future CSNPs’ development.
Language: Английский
Citations
5
Poultry Science, Journal Year: 2025, Volume and Issue: 104(2), P. 104762 - 104762
Published: Jan. 1, 2025
In this study, phthalate inulin nanoparticles (PINs) were chemically modified and characterized. The internalization of PINs into the probiotic E. faecalis, which delivering Fiber2 protein fowl adenovirus serotype 4 (FAdV-4), was investigated. expression in faecalis detected using western blot analysis. To protect recombinant from degradation gastric acid environment, sodium alginate used to encapsulate bacteria. survival ratio release simulated gastrointestinal fluid assessed. Oral administration microencapsulated loaded with (Micro-E/Fiber2-PINs) or (Micro-E/Fiber2-inulin) conducted, followed by an experimental challenge FAdV-4 chickens evaluate immune responses protection. results showed bacteria promoted growth, significantly improved level Fiber2. After incubation fluid, number viable Micro-E/Fiber2-PINs group higher than that faecalis/Fiber2 group. microcapsules completed within 30 min. Animal experiments demonstrated oral immunization enhanced humoral cellular responses, relieved inflammatory injury FAdV-targeted organs, rate challenged chickens. This study presents promising potential for developing vaccines against pathogen infection.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
Abstract The complex composition of traditional Chinese medicines (TCMs) has posed challenges for in‐depth study and global application, despite their abundance bioactive compounds that make them valuable resources disease treatment. To overcome these obstacles, it is essential to modernize TCMs by focusing on precise This involves elucidating the structure‐activity relationships within compositions, ensuring accurate in vivo delivery, monitoring delivery process. review discusses research progress precision treatment from three perspectives: spatial multi‐omics technology therapeutic activity, carrier systems medical imaging visualizing aim establish a novel paradigm advances therapy TCMs.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 238 - 238
Published: Feb. 12, 2025
Metabolic diseases like obesity and diabetes are on the rise, therapies with biomacromolecules (such as proteins, peptides, antibodies, oligonucleotides) play a crucial role in their treatment. However, these drugs traditionally injected. For patients chronic (e.g., metabolic diseases), long-term injections accompanied by inconvenience low compliance. Oral administration is preferred, but delivery of challenging due to gastrointestinal barriers. In this article, we introduce available biomacromolecule for treatment diseases. The barriers oral drug strategies overcome also explored. We then discuss alleviating defects, including glucose metabolism, lipid energy such insulin, glucagon-like peptide-1 receptor agonists, proprotein convertase subtilisin/kexin type 9 inhibitors, fibroblast growth factor 21 analogues, peptide YY analogues.
Language: Английский
Citations
0
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract Oral drug delivery is a promising approach for the treatment of various gastrointestinal (GI) diseases but poses significant challenges to target non‐GI diseases. The intestinal barrier forms anatomical challenge reach diseased site, along with physiological such as stability in GI tract. These lead development targeted nanoparticles and strategies cross protect them from harsh conditions tract, improving absorption into circulatory system, bioavailability, ensuring regulated release. Targeting ligands chitosan, Butyrate (BU), yeast capsule (YC) shows effective permeability across epithelium. After crossing epithelium, these can effectively treat atherosclerosis, cancers, neurodegenerative diseases, fibrosis, post‐traumatic osteoarthritis. However, including low bioavailability still persist, which reduce efficacy therapeutics should be considered designing potential therapies near future.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125439 - 125439
Published: March 1, 2025
Language: Английский
Citations
0
Theranostics, Journal Year: 2025, Volume and Issue: 15(8), P. 3551 - 3570
Published: Feb. 25, 2025
Diabetes mellitus (DM) is a chronic metabolic disorder that significantly affects various organ systems. The systemic effects of DM lead to numerous complications, with ocular manifestations being particular concern due their severity and impact on quality life. Hyperglycemia-induced damage often results in range lesions, including diabetic retinopathy (DR), keratopathy, cataracts, glaucoma. These conditions impose considerable physical discomfort patients place substantial economic burden healthcare advent nanotechnology has facilitated the development innovative therapeutic strategies for managing complications. This review highlights several common complications associated DM, focusing pathogenesis treatment strategies. Emphasis placed applications potential treating
Language: Английский
Citations
0