Guizhi Fuling capsules can alleviate bortezomib-induced peripheral neuropathy by decreasing Interleukin-6 levels to regulate mTOR pathway-induced autophagy
Jiaqi Fu,
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Qian Li,
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Runjie Sun
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et al.
Phytomedicine,
Journal Year:
2025,
Volume and Issue:
139, P. 156494 - 156494
Published: Feb. 11, 2025
Language: Английский
Thioridazine induces pyrolysis and autophagy in epithelial ovarian cancer
Min Yong,
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Yue Xiang,
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Pu Xia
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et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 14, 2025
Abstract
Thioridazine
exhibits
inhibitory
effects
on
various
tumors,
including
epithelial
ovarian
cancer,
but
the
mechanisms
remain
unclear.
Proliferation
and
invasion
were
assessed
using
CCK8
Matrigel
assays.
Autophagy
pyroptosis-related
markers
detected
via
Western
blot.
flux
was
tracked
mRFP-GFP-LC3
reporter.
inhibitors
3MA
andBufA1
used
to
confirm
whether
autophagy
functioning
properly.
RNA
sequencing
performed
identify
differentially
expressed
genes,
Co-IP
detect
interacting
proteins.
A
subcutaneous
tumorigenesis
experiment
in
nude
mice
conducted
evaluate
effect
of
thioridazine
vivo.
As
a
result,
inhibited
proliferation
EOC
while
promoting
pyroptosis.
The
upregulation
pyroptosis
marker
NLRP3
may
be
attributed
DRD2
inhibition.
Inhibition
enhanced
expression,
inhibitor
CQ
increased
tumor-inhibiting
thioridazine.
In
conclusion,
by
inducing
autophagy,
with
playing
protective
role
treatment.
combined
an
effective
treatment
for
EOC.
Language: Английский
Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport
John M. Haynes,
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Arnav Joshi,
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Ross C. Larue
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et al.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1592 - 1592
Published: Dec. 13, 2024
Nucleoside
reverse
transcriptase
inhibitors
(NRTIs)
are
the
backbone
of
highly
active
antiretroviral
therapy
(HAART)—the
current
standard
care
for
treating
human
immunodeficiency
virus
(HIV)
infection.
Despite
their
efficacy,
NRTIs
cause
numerous
treatment-limiting
adverse
effects,
including
a
distinct
peripheral
neuropathy,
called
toxic
neuropathy
(ATN).
ATN
primarily
affects
extremities
with
shock-like
tingling
pain,
pins-and-needles
prickling
sensation,
and
numbness.
its
negative
impact
on
patient
quality
life,
remains
poorly
understood,
which
limits
treatment
options
potential
interventions
people
living
HIV
(PLWH).
Elucidating
underlying
pathophysiology
NRTI-induced
will
facilitate
development
effective
strategies
improved
outcomes.
In
this
article,
we
comprehensively
review
in
setting
NRTI
Language: Английский