Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport DOI Creative Commons

John M. Haynes,

Arnav Joshi, Ross C. Larue

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1592 - 1592

Published: Dec. 13, 2024

Nucleoside reverse transcriptase inhibitors (NRTIs) are the backbone of highly active antiretroviral therapy (HAART)—the current standard care for treating human immunodeficiency virus (HIV) infection. Despite their efficacy, NRTIs cause numerous treatment-limiting adverse effects, including a distinct peripheral neuropathy, called toxic neuropathy (ATN). ATN primarily affects extremities with shock-like tingling pain, pins-and-needles prickling sensation, and numbness. its negative impact on patient quality life, remains poorly understood, which limits treatment options potential interventions people living HIV (PLWH). Elucidating underlying pathophysiology NRTI-induced will facilitate development effective strategies improved outcomes. In this article, we comprehensively review in setting NRTI

Language: Английский

Guizhi Fuling capsules can alleviate bortezomib-induced peripheral neuropathy by decreasing Interleukin-6 levels to regulate mTOR pathway-induced autophagy DOI
Jiaqi Fu, Qian Li, Runjie Sun

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156494 - 156494

Published: Feb. 11, 2025

Language: Английский

Citations

0
Thioridazine induces pyrolysis and autophagy in epithelial ovarian cancer DOI
Min Yong,

Yue Xiang,

Pu Xia

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Abstract Thioridazine exhibits inhibitory effects on various tumors, including epithelial ovarian cancer, but the mechanisms remain unclear. Proliferation and invasion were assessed using CCK8 Matrigel assays. Autophagy pyroptosis-related markers detected via Western blot. flux was tracked mRFP-GFP-LC3 reporter. inhibitors 3MA andBufA1 used to confirm whether autophagy functioning properly. RNA sequencing performed identify differentially expressed genes, Co-IP detect interacting proteins. A subcutaneous tumorigenesis experiment in nude mice conducted evaluate effect of thioridazine vivo. As a result, inhibited proliferation EOC while promoting pyroptosis. The upregulation pyroptosis marker NLRP3 may be attributed DRD2 inhibition. Inhibition enhanced expression, inhibitor CQ increased tumor-inhibiting thioridazine. In conclusion, by inducing autophagy, with playing protective role treatment. combined an effective treatment for EOC.

Language: Английский

Citations

0
Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport DOI Creative Commons

John M. Haynes,

Arnav Joshi, Ross C. Larue

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1592 - 1592

Published: Dec. 13, 2024

Nucleoside reverse transcriptase inhibitors (NRTIs) are the backbone of highly active antiretroviral therapy (HAART)—the current standard care for treating human immunodeficiency virus (HIV) infection. Despite their efficacy, NRTIs cause numerous treatment-limiting adverse effects, including a distinct peripheral neuropathy, called toxic neuropathy (ATN). ATN primarily affects extremities with shock-like tingling pain, pins-and-needles prickling sensation, and numbness. its negative impact on patient quality life, remains poorly understood, which limits treatment options potential interventions people living HIV (PLWH). Elucidating underlying pathophysiology NRTI-induced will facilitate development effective strategies improved outcomes. In this article, we comprehensively review in setting NRTI

Language: Английский

Citations

0