STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

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Spectroscopic Characterization Using 1H and 13C Nuclear Magnetic Resonance and Computational Analysis of the Complex of Donepezil with 2,6-Methyl-β-Cyclodextrin and Hydroxy Propyl Methyl Cellulose

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1169 - 1169

Published: March 5, 2025

Donepezil (DH), a selective acetylcholinesterase inhibitor, is widely used to manage symptoms of mild moderate Alzheimer's disease by enhancing cholinergic neurotransmission and preventing acetylcholine breakdown. Despite the effectiveness oral formulations, extensive hepatic metabolism low systemic bioavailability have driven search for alternative delivery systems. This study focuses on nasal as non-parenteral substitute, utilizing hydroxypropyl methylcellulose (HPMC) its mucoadhesive properties methyl-β-cyclodextrin (Me-β-CD) ability enhance permeability form inclusion complexes with drugs. Prior studies demonstrated potential HPMC-based films nose-to-brain donepezil highlighted Me-β-CD's role in improving drug solubility. Building this, transparent gel formulations containing DH, HPMC, 2,6 Me-β-CD were developed investigate molecular interactions within two- three-component utilized combination nuclear magnetic resonance (NMR) spectroscopy density functional theory (DFT) provide detailed insights into between 2,6-Me-β-CD, HPMC. The findings critical drug-excipient interactions, aiding optimization stability, solubility, controlled release. advances rational design nanotechnology-based systems enhanced therapeutic efficacy.

Language: Английский

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Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-co-glycolic Acid (nfPLGA) During Co-Precipitation

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 77 - 77

Published: Jan. 8, 2025

Background/Objectives: The co-formulation of active pharmaceutical ingredients (APIs) is a growing strategy in biopharmaceutical development, particularly when it comes to improving solubility and bioavailability. This study explores co-precipitation method prepare co-formulated crystals griseofulvin (GF) dexamethasone (DXM), utilizing nanostructured, functionalized polylactic glycolic acid (nfPLGA) as enhancer. Methods: An antisolvent precipitation technique was employed incorporate nfPLGA at 3% concentration into the GF DXM, referred DXM-GF-nfPLGA. dissolution performance this formulation compared that pure drugs co-precipitated DXM-GF without nfPLGA. Results: Several characterization techniques, including electron microscopy (SEM), RAMAN, FTIR, TGA, XRD, were used analyze incorporation co-formulations. inclusion significantly enhanced initial rate both DXM DXM-GF-nfPLGA formulation, achieving maximum 100%, which not attained by or formulation. also reduced amount time taken reach 50% (T50) 80% (T80) dissolution. T50 values decreased from 52 82 min (for GF) 23 for DXM-GF-nfPLGA, T80 improved 50 outpacing compounds. Furthermore, incorporating crystal structures greatly accelerated rates, with rates reaching 650.92 µg/min 540.60 DXM-GF, while showed lower rates. Conclusions: work demonstrates enhances forming water channels within API via hydrogen-bonding interactions. innovative holds promise developing hydrophobic co-formulations faster

Language: Английский

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Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 566 - 566

Published: Jan. 10, 2025

Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To address this, solid dispersions of APG were prepared using ball milling sodium alginate (SA), Pluronic® F-68 (PLU68), F-127 (PLU127), PVP K30, and VA64 as polymeric excipients. These screened for apparent solubility in buffers pH 1.2, 5.5, 6.8. Based on improved after 60 min, APG-PLU68 APG-PLU127 selected further study. DSC FT-IR analysis confirmed molecular interactions between the polymer matrices, contributing to enhanced dissolution rates. Dissolution rate studies showed that achieved 100% at 6.8, suggesting potential use environments such small intestine. Additionally, exhibited 84.3% indicating oral dosage forms, where could be absorbed acidic conditions stomach. The stability study storage one year under ambient does not cause chemical degradation but affects physical state dispersion. Antioxidant activity was assessed ABTS assay. Freshly obtained 68.1% ± 1.94% activity, whereas stored 66.2% 1.62% (significant difference, p < 0.05). difference related slight decrease dispersion (T0 = 252 1 μg∙mL-1, T1 246 μg∙mL-1). findings demonstrate superior performance PLU127 carrier enhancing release, antioxidant APG.

Language: Английский

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Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV–Vis Monitoring of L* as a Real-Time Response

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 151 - 151

Published: Jan. 23, 2025

Background: This study demonstrates the application of sequential design experiments (DoE) approach within quality by (QbD) framework to optimize extrusion processes through screening, optimization, and robustness testing. Methods: An in-line UV–Vis process analytical technology (PAT) system was successfully employed monitor critical attributes (CQAs) piroxicam amorphous solid dispersion (ASD) products, specifically lightness (L*). Results: L* measurement proved highly effective for ensuring uniformity ASDs, offering real-time insights into their physical appearance stability. Small variations in acted as early indicators processing issues, such phase separation or bubble formation, enabling timely intervention. straightforward rapid technique supports monitoring control, allowing automated adjustments maintain product consistency quality. By adopting this strategy, manufacturers can minimize variability, reduce waste, ensure adherence target profiles (QTPPs). Conclusions: Overall, highlights value spectroscopy a PAT tool hot melt extrusion, enhancing CQA assessment advancing efficiency reliability ASD manufacturing.

Language: Английский

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Meticulous Standards for Bio-relevant Method Development and Validation of In Vitro Release Testing for Regenerative Topicals: A Comprehensive Review

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

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Exploration of Enalapril-Lacidipine Co-Amorphous System with Superior Dissolution, In vivo Absorption and Physical Stability via Incorporated into Mesoporous Silica

European Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 207, P. 107033 - 107033

Published: Feb. 5, 2025

In the present study, enalapril (ENP) was taking as a potential co-former to fabricate co-amorphous system with lacidipine (LCDP). The ENP/LCDP firstly prepared or without mesoporous SiO2 and characterized by DSC, XRD SEM technologies. molecular interactions were evaluated FTIR spectrums. Furthermore, dissolution pharmacokinetics behavior of various formulations also carried out. It demonstrated that completely co-amorphization obtained at 2:1 molar ratio intermolecular between ENP LCDP. significantly improve rate LCDP respectively. Compared naked system, remarkable enhancement bioavailability model drugs observed incorporated into SiO2, superior physical stability after accelerated study. Raman mapping revealed less microstructure phase separation could be main reason for better in presence SiO2. conclusion, successfully used poorly water-soluble collaborates become promising strategy achieve stable amorphous formulation further bioavailability.

Language: Английский

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Molecular insights into the antineoplastic potential of apigenin and its derivatives: paving the way for nanotherapeutic innovations

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Apigenin, a widely distributed bioactive flavonoid, has recently gained excellent attention among researchers as an effective anticancer drug that can alternate cancer signaling pathways, induce programmed cell death, and reduce tumor growth in various types. Despite its impressive anti-neoplastic activity, high hydrophobicity nonspecific biodistribution make apigenin difficult for pharmaceutical application. We highlighted the therapeutic potential of derivatives different types, along with their mechanism action. Nanoengineered delivery systems have remarkable applications minimizing degradation enhancing efficacy drugs sustained release, prolonged blood retention time, reduced off-target toxicities. This review evaluated explored molecular interactions this novel flavonoid pathways to selectively inhibit neoplastic development multiple To ensure complete coverage research area, google scholar, PubMed, web science were used find not only most relevant, but also connected similar articles. A comprehensive overview nanotherapy treatment establish platform overcome difficulties application efficient clinical translation from bench bedside.

Language: Английский

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Native and modified β-cyclodextrins as solubility enhancers for methotrexate loaded in iota-carrageenan hydrogel

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127407 - 127407

Published: March 1, 2025

Language: Английский

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Emerging trends in chitosan based colloidal drug delivery systems: A translational journey from research to practice

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123604 - 123604

Published: April 1, 2025

Language: Английский

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