Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure DOI Creative Commons
Haoyuan Zheng, Yuan Tian, Dongyu Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 29, 2025

Heart failure (HF) is a prevalent and critical cardiac condition that leads to profound structural functional changes in the heart. Although traditional treatments have shown partial efficacy, long-term outcomes remain suboptimal. Emerging research has highlighted pivotal role of oxidative stress ferroptosis HF progression. This study investigates new therapeutic approach utilizing antioxidant polyphenol nanoparticles loaded with STAT3 agonist (PN@Col) target these pathways improve age-related HF. Key cells genes contributing progression were identified via analysis GEO database, single-cell RNA sequencing (scRNA-seq) AUCell used evaluate differential gene expression. The was as essential, its functionality further validated vitro through cell experiments, confirming impact on cardiomyocytes (CMs) Following development PN@Col, experiments showed PN@Col effectively reduced CMs. In vivo studies elderly mice demonstrated significant improvements function following treatment. offers promising by mitigating cardiomyocytes. These findings provide solid scientific foundation for potential novel treatment strategy HF, supporting exploration toward clinical application.

Language: Английский

Single-cell multi-omics analysis reveals the mechanism of action of a novel antioxidant polyphenol nanoparticle loaded with STAT3 agonist in mediating cardiomyocyte ferroptosis to ameliorate age-related heart failure DOI Creative Commons
Haoyuan Zheng, Yuan Tian, Dongyu Li

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 29, 2025

Heart failure (HF) is a prevalent and critical cardiac condition that leads to profound structural functional changes in the heart. Although traditional treatments have shown partial efficacy, long-term outcomes remain suboptimal. Emerging research has highlighted pivotal role of oxidative stress ferroptosis HF progression. This study investigates new therapeutic approach utilizing antioxidant polyphenol nanoparticles loaded with STAT3 agonist (PN@Col) target these pathways improve age-related HF. Key cells genes contributing progression were identified via analysis GEO database, single-cell RNA sequencing (scRNA-seq) AUCell used evaluate differential gene expression. The was as essential, its functionality further validated vitro through cell experiments, confirming impact on cardiomyocytes (CMs) Following development PN@Col, experiments showed PN@Col effectively reduced CMs. In vivo studies elderly mice demonstrated significant improvements function following treatment. offers promising by mitigating cardiomyocytes. These findings provide solid scientific foundation for potential novel treatment strategy HF, supporting exploration toward clinical application.

Language: Английский

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