Targeting tumor-associated macrophages in colon cancer: mechanisms and therapeutic strategies DOI Creative Commons

Jianqin Xiang,

Jian Wang, Huihui Xiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Colon cancer (CC) remains a primary contributor to cancer-related fatalities worldwide, driven by difficulties in early diagnosis and constrained therapeutic options. Recent studies underscore the importance of tumor microenvironment (TME), notably tumor-associated macrophages (TAMs), fostering malignancy progression therapy resistance. Through their inherent plasticity, TAMs facilitate immunosuppression, angiogenic processes, metastatic spread, drug tolerance. In contrast M1 macrophages, which promote inflammatory tumoricidal responses, M2 support expansion dissemination exerting immunosuppressive pro-angiogenic influences. Consequently, manipulating has emerged as potential avenue enhance treatment effectiveness. This review outlines origins, polarization states, functions CC, highlights role driving advancement, surveys ongoing efforts target these cells for better patient outcomes. Emerging strategies aimed at modulating TAM - including depletion strategies, reprogramming approaches that shift M2-polarized toward an phenotype, inhibition key signaling pathways sustaining TAM-mediated immunosuppression-are currently under active investigation. These hold promise overcoming induced resistance improving immunotherapeutic efficacy CC.

Language: Английский

Chitosan-Coated Silver Nanourchins for Imatinib Mesylate Delivery: Biophysical Characterization, In-Silico Profiling, and Anti-Colon Cancer Efficacy DOI
Sankha Bhattacharya,

Aalind Joshi,

Vishal Beldar

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

This study investigates the synthesis and characterization of silver nanourchins coated with chitosan (IMT-CS-AgNUs) as a novel platform for delivery imatinib mesylate (IMT) treatment colon cancer. In-silico analysis discovered 10 key metabolites IMT, which have associated respiratory neurotoxic risks. Molecular docking studies showed high affinity binding IMT to critical proteins, including BCL2 (−6.637 kcal/mol), Caspase-6, EGFR, proved its potential therapeutic value. IMT-CS-AgNUs were prepared by ionic gelation, nanoparticles had size 192.98 nm, an entrapment efficiency 85.7%. The FTIR XRD structural confirmed that nanocarriers stable amorphous in nature. In vitro HCT116 cells significantly increased cytotoxicity IC50 0.4 μg/mL; apoptosis 42.5% ROS generation 47.8% when compared only IMT. release drugs from was sustained over 85% 60 h, selectively inhibited pathogenic bacteria without harming beneficial microbes, antiangiogenic activity, is validated through HET-CAM assay. Gene expression analyses there marked downregulation upregulation apoptotic genes. Pharmacokinetic Wistar rats improved bioavailability 1.8, allows targeted drug concentrations lessened systemic toxicity. Thus, development represents potent approach therapy against cancer, providing efficacy, controlled release, added safety.

Language: Английский

Citations

0
Targeting tumor-associated macrophages in colon cancer: mechanisms and therapeutic strategies DOI Creative Commons

Jianqin Xiang,

Jian Wang, Huihui Xiao

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Colon cancer (CC) remains a primary contributor to cancer-related fatalities worldwide, driven by difficulties in early diagnosis and constrained therapeutic options. Recent studies underscore the importance of tumor microenvironment (TME), notably tumor-associated macrophages (TAMs), fostering malignancy progression therapy resistance. Through their inherent plasticity, TAMs facilitate immunosuppression, angiogenic processes, metastatic spread, drug tolerance. In contrast M1 macrophages, which promote inflammatory tumoricidal responses, M2 support expansion dissemination exerting immunosuppressive pro-angiogenic influences. Consequently, manipulating has emerged as potential avenue enhance treatment effectiveness. This review outlines origins, polarization states, functions CC, highlights role driving advancement, surveys ongoing efforts target these cells for better patient outcomes. Emerging strategies aimed at modulating TAM - including depletion strategies, reprogramming approaches that shift M2-polarized toward an phenotype, inhibition key signaling pathways sustaining TAM-mediated immunosuppression-are currently under active investigation. These hold promise overcoming induced resistance improving immunotherapeutic efficacy CC.

Language: Английский

Citations

0