Vidyodaya Journal of Science, Journal Year: 2024, Volume and Issue: 27(02)

Published: Dec. 30, 2024

Nanozymes, artificial nanomaterials mimicking enzyme activity, are at the forefront of innovative cancer therapies, particularly in chemodynamic therapy (CDT), photodynamic (PDT), and photothermal (PTT). Their capacity to selectively generate reactive oxygen species under tumor-specific conditions, including low pH high H₂O₂ levels, facilitates targeted induction cell death while minimizing damage healthy tissues. When integrated with PDT or PTT, nanozymes enhance oxidative stress promote immunogenic death, further amplifying anti-tumor immune responses. Recent advances single-atom intelligent have shown promise overcoming therapeutic limitations, such as tumor hypoxia suppression modulating microenvironment boost treatment efficacy. Additionally, ongoing preclinical clinical evaluations highlight potential synergistically immunotherapy outcomes. advantages over traditional enzymes, stability, tunability, cost-effectiveness, ability maintain catalytic activity hostile environments, position transformative agents therapy. However, their translation faces significant challenges, biocompatibility concerns, delivery inefficiencies sites, stringent regulatory hurdles, which require comprehensive research solutions address. Despite these advancements nanozyme design functionalization continue pave way for more effective safer applications will be discussed detail this review.Keywords: Cancer therapy, Nanomaterial, ROS, (PTT)

Language: Английский