International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(1), P. 730 - 730
Published: Jan. 1, 2023
The
present
study
aimed
to
investigate
the
relationship
between
concentrations
of
bisphenols
residues
in
amniotic
fluid
(AF)
samples
collected
during
amniocentesis
and
fetal
chromosomal
abnormalities
pregnant
women.
A
total
33
Polish
women
aged
24
44
years,
screened
detect
high
risk
for
defects
first
trimester,
were
included
this
study.
Samples
from
these
patients
routine
diagnostic
treatment
procedures
at
mid-gestation.
various
determined
by
liquid
chromatography
coupled
with
triple
quadrupole
tandem
mass
spectrometry
(LC-ESI-QqQ-MS/MS).
Residues
eight
analytes
(BPS,
BPF,
BPA,
BPAF,
BADGE,
BADGE•2H2O,
BADGE•H2O•HCl
BADGE•2HCl)
detected
range
0.69
ng/mL
3.38
ng/mL.
Fetuses
showed
a
slightly
higher
frequency
occurrence
selected
AF
15-26
weeks
pregnancies.
Finally,
proposed
method
was
applied
simultaneous
determination
several
endocrine-disrupting
chemicals
bisphenol
group
human
samples.
has
been
identified
taken
older
than
average
examined
group.
number
compounds
significant
following
analytes:
BPS,
BADGE.
may
be
an
attractive
alternative
application
large-scale
biomonitoring
studies.
Environment & Health,
Journal Year:
2024,
Volume and Issue:
2(6), P. 373 - 380
Published: May 1, 2024
Bisphenol
AP
(BPAP)
is
a
bisphenol
analogue
that
used
as
substitute
for
BPA
in
industrial
production
and
now
commonly
found
the
environment.
Currently,
there
limited
information
available
on
its
developmental
toxicity
aquatic
organisms.
This
study
exploited
zebrafish
embryos
to
investigate
adverse
effects
of
BPAP
exposure
during
their
early
life
stages.
The
results
revealed
had
median
lethal
concentration
(LC50)
36,
22,
8.5
μmol/L
at
24,
48,
72
h
post
fertilization
(hpf),
respectively.
Additionally,
led
abnormal
development
embryos,
including
hatching
delay,
malformation,
inhibition
spontaneous
movements.
Transcriptomic
analysis
further
upregulated
mRNA
expression
levels
genes
related
inflammatory
pathways,
such
il1b,
ptgs2b,
fosab,
indicating
induction
an
response.
Overall,
our
findings
provide
valuable
insights
into
environmental
health
risks
associated
with
exposure.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
260, P. 115098 - 115098
Published: June 1, 2023
As
a
result
of
the
ban
on
bisphenol
A
(BPA),
hormone
disruptor
with
developmental
neurotoxicity,
several
BPA
derivatives
(BPs)
have
been
widely
used
in
industrial
production.
However,
there
are
no
effective
methods
for
assessing
neurodevelopmental
toxic
effects
BPs.
To
address
this,
Drosophila
exposure
model
was
established,
and
W1118
reared
food
containing
these
Results
showed
that
each
BPs
displayed
different
semi-lethal
doses
ranging
from
1.76
to
19.43
mM.
Exposure
delayed
larval
development
affected
axonal
growth,
resulting
abnormal
crossing
midline
axons
β
lobules
mushroom
bodies,
but
damage
caused
by
BPE
BPF
relatively
minor.
BPC,
BPAF,
BPAP
most
significant
locomotor
behavior,
whereas
BPC
exhibited
social
interactions.
Furthermore,
high-dose
BPA,
BPS,
also
significantly
increased
expression
estrogen-related
receptors.
These
demonstrated
kinds
had
levels
toxicity,
severity
BPZ
>
BPAF
BPB
BPS
≈
BPAl
BPE.
Therefore,
BPZ,
should
be
evaluated
as
potential
alternatives
BPA.
Chemosphere,
Journal Year:
2024,
Volume and Issue:
364, P. 143147 - 143147
Published: Aug. 19, 2024
BPA
and
its
analogues
are
facing
increasingly
stringent
regulations
restricting
their
use
due
to
the
increasing
knowledge
of
harmful
effects.
It
is
therefore
expected
that
novel
alternatives
will
replace
them
in
plastic
products,
cans
thermal
paper
circumvent
restrictions
imposed
by
legislation.
This
raises
concerns
about
safety
"BPA-free"
as
they
contain
substitutes
whose
has
not
been
sufficiently
assessed
prior
market
introduction.
The
regulatory
agencies
have
recognised
BPAP,
BPBP,
BPC2,
BPE,
BPFL,
BPG,
BPP,
BPPH,
BPS-MAE,
BPS-MPE,
BP-TMC,
BPZ
BTUM,
D-90,
UU
PF201
compound
with
insufficient
data
regarding
safety.
We
demonstrate
mentioned
compounds
present
consumer
food
environment,
thus
exhibiting
toxicological
risk
only
humans,
but
also
other
species
where
toxic
effects
already
described.
Results
silico,
vitro
vivo
studies
examining
endocrine
disruption
show
disrupt
system
targeting
various
nuclear
receptors,
impairing
reproductive
function
causing
such
hepatotoxicity,
altered
behaviour
impaired
function.
In
on
literally
non-existent,
although
these
commonly
used
papers.
However,
silico
predicted
might
cause
adverse
well.
aim
this
article
comprehensively
collate
information
selected
illustrate
potential
toxicity
identify
gaps.
