International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(1), P. 730 - 730
Published: Jan. 1, 2023
The
present
study
aimed
to
investigate
the
relationship
between
concentrations
of
bisphenols
residues
in
amniotic
fluid
(AF)
samples
collected
during
amniocentesis
and
fetal
chromosomal
abnormalities
pregnant
women.
A
total
33
Polish
women
aged
24
44
years,
screened
detect
high
risk
for
defects
first
trimester,
were
included
this
study.
Samples
from
these
patients
routine
diagnostic
treatment
procedures
at
mid-gestation.
various
determined
by
liquid
chromatography
coupled
with
triple
quadrupole
tandem
mass
spectrometry
(LC-ESI-QqQ-MS/MS).
Residues
eight
analytes
(BPS,
BPF,
BPA,
BPAF,
BADGE,
BADGE•2H2O,
BADGE•H2O•HCl
BADGE•2HCl)
detected
range
0.69
ng/mL
3.38
ng/mL.
Fetuses
showed
a
slightly
higher
frequency
occurrence
selected
AF
15-26
weeks
pregnancies.
Finally,
proposed
method
was
applied
simultaneous
determination
several
endocrine-disrupting
chemicals
bisphenol
group
human
samples.
has
been
identified
taken
older
than
average
examined
group.
number
compounds
significant
following
analytes:
BPS,
BADGE.
may
be
an
attractive
alternative
application
large-scale
biomonitoring
studies.
Safer
chemical
alternatives
to
bisphenol
(BP)
have
been
a
major
pursuit
of
modern
green
chemistry
and
toxicology.
Using
similarity-based
approach,
it
is
difficult
identify
minor
structural
differences
that
contribute
the
significant
changes
toxicity.
Here,
we
used
omics
computational
toxicology
features
associated
with
BP
analogue-induced
embryonic
toxicity,
offering
valuable
insights
inform
design
safer
alternatives.
The
zebrafish
acute
behavioral
effects,
concentration-dependent
transcriptome
analysis
17
analogues
were
tested,
structure
characteristics
key
biological
activities-induced
toxicity
explored.
BPE,
BPF,
BPP,
BPBP,
BPS
induced
lower
lethality
than
BPA.
And,
8
triggered
hyperactive
behavior
at
environmentally
human
relevant
concentrations.
phenol
rings
linked
via
hydrophobic
segments
("chain:alkaneBranch_neopentyl_C5")
disturbed
stress
response,
leading
lethality,
introducing
groups
on
meta
position
augmented
their
effects.
"3DACorr_TotChg_3"
physicochemical
feature
for
disorders,
3DACorr_TotChg_3
value
<
0.11
could
induce
by
perturbing
neurodevelopment
pathways.
This
study
provides
an
integrated
strategy,
combining
data-driven
profiling
mechanism-based
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(1), P. 730 - 730
Published: Jan. 1, 2023
The
present
study
aimed
to
investigate
the
relationship
between
concentrations
of
bisphenols
residues
in
amniotic
fluid
(AF)
samples
collected
during
amniocentesis
and
fetal
chromosomal
abnormalities
pregnant
women.
A
total
33
Polish
women
aged
24
44
years,
screened
detect
high
risk
for
defects
first
trimester,
were
included
this
study.
Samples
from
these
patients
routine
diagnostic
treatment
procedures
at
mid-gestation.
various
determined
by
liquid
chromatography
coupled
with
triple
quadrupole
tandem
mass
spectrometry
(LC-ESI-QqQ-MS/MS).
Residues
eight
analytes
(BPS,
BPF,
BPA,
BPAF,
BADGE,
BADGE•2H2O,
BADGE•H2O•HCl
BADGE•2HCl)
detected
range
0.69
ng/mL
3.38
ng/mL.
Fetuses
showed
a
slightly
higher
frequency
occurrence
selected
AF
15-26
weeks
pregnancies.
Finally,
proposed
method
was
applied
simultaneous
determination
several
endocrine-disrupting
chemicals
bisphenol
group
human
samples.
has
been
identified
taken
older
than
average
examined
group.
number
compounds
significant
following
analytes:
BPS,
BADGE.
may
be
an
attractive
alternative
application
large-scale
biomonitoring
studies.
